4NY5
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4PPO
| First Crystal Structure for an Oxaliplatin-Protein Complex | Descriptor: | 1,2-ETHANEDIOL, CYCLOHEXANE-1(R),2(R)-DIAMINE-PLATINUM(II), Lysozyme C, ... | Authors: | Messori, L, Merlino, A. | Deposit date: | 2014-02-27 | Release date: | 2015-01-14 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | The X-ray structure of the complex formed in the reaction between oxaliplatin and lysozyme. Chem.Commun.(Camb.), 50, 2014
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4OT4
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3M1J
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8B0T
| SARS-CoV-2 Main Protease adduct with Au(PEt3)Br | Descriptor: | 3C-like proteinase nsp5, GOLD ION | Authors: | Massai, L, Grifagni, D, De Santis, A, Geri, A, Calderone, V, Cantini, F, Banci, L, Messori, L. | Deposit date: | 2022-09-08 | Release date: | 2022-12-28 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Gold-Based Metal Drugs as Inhibitors of Coronavirus Proteins: The Inhibition of SARS-CoV-2 Main Protease by Auranofin and Its Analogs. Biomolecules, 12, 2022
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8B0S
| SARS-COV-2 Main Protease adduct with Au(NHC)Cl | Descriptor: | 3C-like proteinase nsp5, GOLD ION | Authors: | Massai, L, Grifagni, D, Desantis, A, Geri, A, Calderone, V, Cantini, F, Messori, L, Banci, L. | Deposit date: | 2022-09-08 | Release date: | 2022-12-28 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.42 Å) | Cite: | Gold-Based Metal Drugs as Inhibitors of Coronavirus Proteins: The Inhibition of SARS-CoV-2 Main Protease by Auranofin and Its Analogs. Biomolecules, 12, 2022
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1NAB
| The crystal structure of the complex between a disaccharide anthracycline and the DNA hexamer d(CGATCG) reveals two different binding sites involving two DNA duplexes | Descriptor: | 5'-D(*CP*GP*AP*TP*CP*G)-3', 7-[5-(4-AMINO-5-HYDROXY-6-METHYL-TETRAHYDRO-PYRAN-2-YLOXY)-4-HYDROXY-6-METHYL-TETRAHYDRO-PYRAN-2-YLOXY]-6,9,11-TRIHYDROXY-9-(2-HYDROXY-ACETYL)-7,8,9,10-TETRAHYDRO-NAPHTHACENE-5,12-DIONE | Authors: | Temperini, C, Messori, L, Orioli, P, Di Bugno, C, Animati, F, Ughetto, G. | Deposit date: | 2002-11-27 | Release date: | 2003-02-25 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | The crystal structure of the complex between a disaccharide anthracycline and the DNA hexamer d(CGATCG) reveals two different binding sites involving two DNA duplexes Nucleic Acids Res., 31, 2003
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2AEO
| Crystal structure of cisplatinated bovine Cu,Zn superoxide dismutase | Descriptor: | COPPER (II) ION, Cisplatin, Superoxide dismutase [Cu-Zn], ... | Authors: | Calderone, V, Casini, A, Mangani, S, Messori, L, Orioli, P.L. | Deposit date: | 2005-07-23 | Release date: | 2006-05-02 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural investigation of cisplatin-protein interactions: selective platination of His19 in a cuprozinc superoxide dismutase. Angew. Chem. Int. Ed. Engl., 45, 2006
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7P7O
| X-RAY CRYSTAL STRUCTURE OF SPOROSARCINA PASTEURII UREASE INHIBITED BY THE GOLD(I)-DIPHOSPHINE COMPOUND Au(PEt3)2Cl DETERMINED AT 1.87 ANGSTROMS | Descriptor: | 1,2-ETHANEDIOL, NICKEL (II) ION, OXYGEN ATOM, ... | Authors: | Mazzei, L, Ciurli, S, Cianci, M, Messori, L, Massai, L. | Deposit date: | 2021-07-20 | Release date: | 2022-06-01 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | Medicinal Au(I) compounds targeting urease as prospective antimicrobial agents: unveiling the structural basis for enzyme inhibition. Dalton Trans, 50, 2021
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2I6Z
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5CCW
| Structure of the complex of a human telomeric DNA with Au(caffein-2-ylidene)2 | Descriptor: | Au(caffein-2-ylidene)2, POTASSIUM ION, human telomeric DNA | Authors: | Ferraroni, M, Bazzicalupi, C, Gratteri, P, Messori, L, Papi, F. | Deposit date: | 2015-07-02 | Release date: | 2016-03-16 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Determinants for Tight and Selective Binding of a Medicinal Dicarbene Gold(I) Complex to a Telomeric DNA G-Quadruplex: a Joint ESI MS and XRD Investigation. Angew.Chem.Int.Ed.Engl., 55, 2016
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5MVB
| Solution structure of a human G-Quadruplex hybrid-2 form in complex with a Gold-ligand. | Descriptor: | DNA (26-MER), POTASSIUM ION, bis(m2-Oxo)-bis(2-methyl-2,2'-bipyridine)-di-gold(iii) | Authors: | Wirmer-Bartoschek, J, Jonker, H.R.A, Bendel, L.E, Gruen, T, Bazzicalupi, C, Messori, L, Gratteri, P, Schwalbe, H. | Deposit date: | 2017-01-16 | Release date: | 2017-05-31 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Solution NMR Structure of a Ligand/Hybrid-2-G-Quadruplex Complex Reveals Rearrangements that Affect Ligand Binding. Angew. Chem. Int. Ed. Engl., 56, 2017
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3O20
| Electron transfer complexes:experimental mapping of the Redox-dependent Cytochrome C electrostatic surface | Descriptor: | Cytochrome c, HEME C, NITRATE ION | Authors: | De March, M, De Zorzi, R, Casini, A, Messori, L, Geremia, S, Demitri, N, Gabbiani, C, Guerri, A. | Deposit date: | 2010-07-22 | Release date: | 2012-01-25 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Nitrate as a probe of cytochrome c surface: crystallographic identification of crucial "hot spots" for protein-protein recognition. J. Inorg. Biochem., 135, 2014
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3O1Y
| Electron transfer complexes: Experimental mapping of the redox-dependent cytochrome c electrostatic surface | Descriptor: | Cytochrome c, HEME C, NITRATE ION | Authors: | De March, M, De Zorzi, R, Demitri, N, Gabbiani, C, Guerri, A, Casini, A, Messori, L, Geremia, S. | Deposit date: | 2010-07-22 | Release date: | 2012-01-25 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Nitrate as a probe of cytochrome c surface: crystallographic identification of crucial "hot spots" for protein-protein recognition. J. Inorg. Biochem., 135, 2014
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