5MVB

Solution structure of a human G-Quadruplex hybrid-2 form in complex with a Gold-ligand.

Summary for 5MVB

• Entry DOI: 10.2210/pdb5mvb/pdb
• NMR Information: BMRB: 34086
• Descriptor: DNA (26-MER), POTASSIUM ION, bis(m2-Oxo)-bis(2-methyl-2,2'-bipyridine)-di-gold(iii) (3 entities in total)
• Functional Keywords: g-quadruplex hybrid, 2 auoxo6, dna
• Biological source: Homo sapiens
• Total number of polymer chains: 1
• Total formula weight: 9072.87

Authors

Wirmer-Bartoschek, J.,Jonker, H.R.A.,Bendel, L.E.,Gruen, T.,Bazzicalupi, C.,Messori, L.,Gratteri, P.,Schwalbe, H. (deposition date: 2017-01-16, release date: 2017-05-31, Last modification date: 2023-06-14)

• Primary citation: Wirmer-Bartoschek, J.,Bendel, L.E.,Jonker, H.R.A.,Grun, J.T.,Papi, F.,Bazzicalupi, C.,Messori, L.,Gratteri, P.,Schwalbe, H.; Solution NMR Structure of a Ligand/Hybrid-2-G-Quadruplex Complex Reveals Rearrangements that Affect Ligand Binding.; Angew. Chem. Int. Ed. Engl., 56:7102-7106, 2017; PubMed: 28524432; DOI: 10.1002/anie.201702135

Experimental method

SOLUTION NMR