2I6Z

X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme

Summary for 2I6Z

Entry DOI	10.2210/pdb2i6z/pdb
Descriptor	Lysozyme C, Cisplatin, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	cisplatin-lysozyme adduct, anticancer drugs, hydrolase
Biological source	Gallus gallus (chicken)
Cellular location	Secreted: P00698
Total number of polymer chains	1
Total formula weight	14744.79
Authors	Temperini, C.,Casini, A.,Messori, L. (deposition date: 2006-08-30, release date: 2007-01-02, Last modification date: 2024-10-30)
Primary citation	Casini, A.,Mastrobuoni, G.,Temperini, C.,Gabbiani, C.,Francese, S.,Moneti, G.,Supuran, C.T.,Scozzafava, A.,Messori, L. ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme. Chem.Commun.(Camb.), :156-158, 2007 Cited by PubMed Abstract: The interactions of cisplatin and its analogues, transplatin, carboplatin and oxaliplatin, with hen egg white lysozyme were analysed through ESI mass spectrometry, and the resulting metallodrug-protein adducts identified; the X-ray crystal structure of the cisplatin lysozyme derivative, solved at 1.9 A resolution, reveals selective platination of imidazole Nepsilon of His15. PubMed: 17180231 DOI: 10.1039/b611122j PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation