4PPO

First Crystal Structure for an Oxaliplatin-Protein Complex

Summary for 4PPO

Entry DOI	10.2210/pdb4ppo/pdb
Descriptor	Lysozyme C, 1,2-ETHANEDIOL, NITRATE ION, ... (5 entities in total)
Functional Keywords	lysozyme fold, hydrolase
Biological source	Gallus gallus (bantam,chickens)
Total number of polymer chains	1
Total formula weight	15198.60
Authors	Messori, L.,Merlino, A. (deposition date: 2014-02-27, release date: 2015-01-14, Last modification date: 2024-10-30)
Primary citation	Messori, L.,Marzo, T.,Merlino, A. The X-ray structure of the complex formed in the reaction between oxaliplatin and lysozyme. Chem.Commun.(Camb.), 50:8360-8362, 2014 Cited by PubMed Abstract: The X-ray structure of the adduct formed between oxaliplatin and the model protein hen egg white lysozyme is reported here. The structure is compared with those of cisplatin and carboplatin derivatives, previously solved. Relevant changes are highlighted among these crystal structures that are suggestive of significant differences in the reactivity of platinum drugs with this protein; possible biological implications are discussed. PubMed: 24943911 DOI: 10.1039/c4cc02254h PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.73 Å)

Structure validation