4OT4
X-ray Structure of the Adduct formed between cisplatin and Ribonuclease A
Summary for 4OT4
| Entry DOI | 10.2210/pdb4ot4/pdb |
| Related | 1JVT |
| Descriptor | Ribonuclease pancreatic, Cisplatin (3 entities in total) |
| Functional Keywords | rnase a fold, hydrolase |
| Biological source | Bos taurus (bovine,cow,domestic cattle,domestic cow) |
| Cellular location | Secreted: P61823 |
| Total number of polymer chains | 2 |
| Total formula weight | 28316.79 |
| Authors | Messori, L.,Merlino, A. (deposition date: 2014-02-13, release date: 2014-07-09, Last modification date: 2024-11-06) |
| Primary citation | Messori, L.,Merlino, A. Cisplatin binding to proteins: molecular structure of the ribonuclease a adduct. Inorg.Chem., 53:3929-3931, 2014 Cited by PubMed Abstract: The crystal structure of the main adduct formed in the reaction between cisplatin and bovine pancreatic ribonuclease is reported here. Notably, in both of the protein molecules present in the asymmetric unit, platinum(II) binding takes place exclusively at the level of Met29. In one of the two molecules, the Gln28 side chain completes the platinum coordination sphere, anchoring the cisplatin fragment to the protein in a bidentate fashion. These results contain interesting implications for understanding the biological chemistry of this important drug. PubMed: 24694179DOI: 10.1021/ic500360f PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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