PDB Search results for query - Protein Data Bank Japan

PDB: 139 results

Calcium-Dependent Protein Kinase from Eimeria tenella
Descriptor:	CALCIUM ION, Calmodulin-like domain protein kinase
Authors:	Merritt, E.A.
Deposit date:	2015-03-17
Release date:	2016-04-06
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (3.19 Å)
Cite:	CDPK is a druggable target in the apicomplexan parasite Eimeria to be published

4YUQ

CDPK1 from Eimeria tenella in complex with inhibitor UW1354
Descriptor:	1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, CALCIUM ION, Calmodulin-like domain protein kinase
Authors:	Merritt, E.A.
Deposit date:	2015-03-19
Release date:	2016-04-06
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.8 Å)
Cite:	CDPK is a druggable target in the apicomplexan parasite Eimeria to be published

3BNW

Crystal structure of riboflavin kinase from Trypanosoma brucei
Descriptor:	Riboflavin kinase, putative
Authors:	Merritt, E.A, Holmes, M, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2007-12-14
Release date:	2008-01-08
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Riboflavin kinase from Trypanosoma brucei. To be Published

4YZB

CDPK1 from Eimeria tenella in complex with inhibitor UW1521
Descriptor:	4-(6-ethoxynaphthalen-2-yl)-6-(piperazin-1-ylmethyl)-2H-indazol-3-amine, CALCIUM ION, Calmodulin-like domain protein kinase
Authors:	Merritt, E.A.
Deposit date:	2015-03-24
Release date:	2016-04-06
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.9 Å)
Cite:	CDPK is a druggable target in the apicomplexan parasite Eimeria to be published

1CHQ

SURPRISING LEADS FOR A CHOLERA TOXIN RECEPTOR BINDING ANTAGONIST; CRYSTALLOGRAPHIC STUDIES OF CTB MUTANTS
Descriptor:	CHOLERA TOXIN B PENTAMER
Authors:	Merritt, E.A, Hol, W.G.J.
Deposit date:	1995-02-15
Release date:	1996-03-08
Last modified:	2021-11-03
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Surprising leads for a cholera toxin receptor-binding antagonist: crystallographic studies of CTB mutants. Structure, 3, 1995

1CHP

SURPRISING LEADS FOR A CHOLERA TOXIN RECEPTOR BINDING ANTAGONIST; CRYSTALLOGRAPHIC STUDIES OF CTB MUTANTS
Descriptor:	CHLORIDE ION, CHOLERA TOXIN B PENTAMER
Authors:	Merritt, E.A, Hol, W.G.J.
Deposit date:	1995-02-15
Release date:	1996-03-08
Last modified:	2021-11-03
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Surprising leads for a cholera toxin receptor-binding antagonist: crystallographic studies of CTB mutants. Structure, 3, 1995

4EQU

Human STK-10 (LOK) kinase domain in DFG-out conformation with inhibitor DSA-7
Descriptor:	CALCIUM ION, N-{3-[(3-{4-[(4-methoxyphenyl)amino]-1,3,5-triazin-2-yl}pyridin-2-yl)amino]-4-methylphenyl}-3-(trifluoromethyl)benzamide, PENTAETHYLENE GLYCOL, ...
Authors:	Merritt, E.A, Larson, E.T.
Deposit date:	2012-04-19
Release date:	2012-11-07
Last modified:	2012-12-19
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Affinity-Based Probes Based on Type II Kinase Inhibitors. J.Am.Chem.Soc., 134, 2012

4DGG

c-SRC kinase domain in complex with RM-1-176
Descriptor:	3-{6-[(3-chlorobenzyl)oxy]naphthalen-2-yl}-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Proto-oncogene tyrosine-protein kinase Src
Authors:	Merritt, E.A, Larson, E.T.
Deposit date:	2012-01-25
Release date:	2012-10-10
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (2.65 Å)
Cite:	Active site profiling reveals coupling between domains in SRC-family kinases. Nat.Chem.Biol., 9, 2013

4DS2

Ubiquitin conjugating enzyme (putative) from Trypanosoma cruzi
Descriptor:	Ubiquitin-conjugating enzyme E2, putative
Authors:	Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2012-02-17
Release date:	2012-02-29
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (2.63 Å)
Cite:	Ubiquitin conjugating enzyme (putative) from Trypanosoma cruzi To be Published

2CHB

CHOLERA TOXIN B-PENTAMER COMPLEXED WITH GM1 PENTASACCHARIDE
Descriptor:	CHOLERA TOXIN, beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-4)-[N-acetyl-alpha-neuraminic acid-(2-3)]beta-D-galactopyranose, beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-4)-[N-acetyl-alpha-neuraminic acid-(2-3)]beta-D-galactopyranose-(1-4)-beta-D-glucopyranose
Authors:	Merritt, E.A, Hol, W.G.J.
Deposit date:	1997-06-03
Release date:	1997-12-03
Last modified:	2023-08-09
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Structural studies of receptor binding by cholera toxin mutants. Protein Sci., 6, 1997

3P0I

Leishmania major Tyrosyl-tRNA synthetase in complex with tyrosinol, cubic crystal form
Descriptor:	4-[(2S)-2-amino-3-hydroxypropyl]phenol, Tyrosyl-tRNA synthetase
Authors:	Merritt, E.A, Larson, E.T, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:	2010-09-28
Release date:	2011-03-23
Last modified:	2023-12-06
Method:	X-RAY DIFFRACTION (3.13 Å)
Cite:	The Double-Length Tyrosyl-tRNA Synthetase from the Eukaryote Leishmania major Forms an Intrinsically Asymmetric Pseudo-Dimer. J.Mol.Biol., 409, 2011

1CT1

CHOLERA TOXIN B-PENTAMER MUTANT G33R BOUND TO RECEPTOR PENTASACCHARIDE
Descriptor:	CHLORIDE ION, CHOLERA TOXIN, beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-4)-[N-acetyl-alpha-neuraminic acid-(2-3)]beta-D-galactopyranose-(1-4)-beta-D-glucopyranose
Authors:	Merritt, E.A, Hol, W.G.J.
Deposit date:	1997-06-03
Release date:	1997-10-15
Last modified:	2023-08-09
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Structural studies of receptor binding by cholera toxin mutants. Protein Sci., 6, 1997

1VJQ

Designed protein based on backbone conformation of procarboxypeptidase-A (1AYE) with sidechains chosen for maximal predicted stability.
Descriptor:	designed protein
Authors:	Merritt, E.A, Baker, D, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2004-03-19
Release date:	2004-03-30
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (2.098 Å)
Cite:	Designed protein based on backbone conformation of procarboxypeptidase-A (1AYE) with sidechains chosen for maximal predicted stability. To be Published

3UPZ

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with bumpless BKI analog UW1243
Descriptor:	1-(piperidin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1
Authors:	Merritt, E.A, Larson, E.T.
Deposit date:	2011-11-18
Release date:	2012-03-14
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1. J.Med.Chem., 55, 2012

3UQF

c-SRC kinase domain in complex with BKI RM-1-89
Descriptor:	3-(6-ethoxynaphthalen-2-yl)-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Proto-oncogene tyrosine-protein kinase Src
Authors:	Merritt, E.A, Larson, E.T.
Deposit date:	2011-11-20
Release date:	2012-03-14
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (2.27 Å)
Cite:	Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1. J.Med.Chem., 55, 2012

3UQG

c-SRC kinase domain in complex with bumpless BKI analog UW1243
Descriptor:	1-(piperidin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Proto-oncogene tyrosine-protein kinase Src
Authors:	Merritt, E.A, Larson, E.T.
Deposit date:	2011-11-20
Release date:	2012-03-14
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1. J.Med.Chem., 55, 2012

3V5T

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1299
Descriptor:	1-[(2S)-2-(dimethylamino)-3-methylbutyl]-3-(6-ethoxynaphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1
Authors:	Merritt, E.A, Larson, E.T.
Deposit date:	2011-12-16
Release date:	2012-03-14
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (2.13 Å)
Cite:	Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1. J.Med.Chem., 55, 2012

3V51

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor RM-1-176
Descriptor:	3-{6-[(3-chlorobenzyl)oxy]naphthalen-2-yl}-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1
Authors:	Merritt, E.A, Larson, E.T.
Deposit date:	2011-12-15
Release date:	2012-03-14
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1. J.Med.Chem., 55, 2012

3V5P

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1288
Descriptor:	3-(4-methoxy-3-methylphenyl)-1-(piperidin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1
Authors:	Merritt, E.A, Larson, E.T.
Deposit date:	2011-12-16
Release date:	2012-03-14
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1. J.Med.Chem., 55, 2012

3UPX

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1300
Descriptor:	Calmodulin-domain protein kinase 1, [2-amino-1-(piperidin-4-ylmethyl)-1H-benzimidazol-6-yl](phenyl)methanone
Authors:	Merritt, E.A, Larson, E.T.
Deposit date:	2011-11-18
Release date:	2012-03-14
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (2.27 Å)
Cite:	Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1. J.Med.Chem., 55, 2012

2Q0X

Alpha/Beta hydrolase fold protein of unknown function
Descriptor:	GLYCEROL, Uncharacterized protein
Authors:	Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2007-05-22
Release date:	2007-06-26
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Structure of a Trypanosoma brucei alpha/beta-hydrolase fold protein with unknown function. Acta Crystallogr.,Sect.F, 64, 2008

2QT8

Coproporphyrinogen III oxidase from Leishmania major
Descriptor:	ACETATE ION, Coproporphyrinogen III oxidase
Authors:	Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2007-08-01
Release date:	2007-09-04
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (1.75 Å)
Cite:	Coproporphyrinogen III oxidase from Leishmania major. To be Published

2QOR

Crystal structure of Plasmodium vivax guanylate kinase
Descriptor:	GUANOSINE-5'-MONOPHOSPHATE, Guanylate kinase, PYROPHOSPHATE 2-
Authors:	Merritt, E.A, Le Trong, I, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2007-07-20
Release date:	2007-08-07
Last modified:	2017-10-25
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Plasmodium vivax guanylate kinase. To be Published

3LC0

Histidyl-tRNA synthetase from Trypanosoma cruzi (Histidine complex)
Descriptor:	HISTIDINE, Histidyl-tRNA synthetase
Authors:	Merritt, E.A, Larson, E.T, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:	2010-01-08
Release date:	2010-01-19
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Crystal Structures of Trypanosomal Histidyl-tRNA Synthetase Illuminate Differences between Eukaryotic and Prokaryotic Homologs. J.Mol.Biol., 397, 2010

1LT5

HEAT-LABILE ENTEROTOXIN B-PENTAMER COMPLEXED WITH THIODIGALACTOSIDE
Descriptor:	HEAT-LABILE ENTEROTOXIN, beta-D-galactopyranose-(1-1)-1-thio-beta-D-galactopyranose
Authors:	Merritt, E.A, Hol, W.G.J.
Deposit date:	1997-09-30
Release date:	1997-12-03
Last modified:	2023-08-09
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Structural foundation for the design of receptor antagonists targeting Escherichia coli heat-labile enterotoxin. Structure, 5, 1997

<123 4 5 6 >

Total results:	139
Displayed results:	25
Sorted by:	Hit score (from highest)
Deposition authors:	"Merritt, E.A"