4EQU
Human STK-10 (LOK) kinase domain in DFG-out conformation with inhibitor DSA-7
Summary for 4EQU
Entry DOI | 10.2210/pdb4equ/pdb |
Descriptor | Serine/threonine-protein kinase 10, N-{3-[(3-{4-[(4-methoxyphenyl)amino]-1,3,5-triazin-2-yl}pyridin-2-yl)amino]-4-methylphenyl}-3-(trifluoromethyl)benzamide, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | serine/threonine kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane; Peripheral membrane protein: O94804 |
Total number of polymer chains | 2 |
Total formula weight | 70178.98 |
Authors | Merritt, E.A.,Larson, E.T. (deposition date: 2012-04-19, release date: 2012-11-07, Last modification date: 2012-12-19) |
Primary citation | Ranjitkar, P.,Perera, B.G.,Swaney, D.L.,Hari, S.B.,Larson, E.T.,Krishnamurty, R.,Merritt, E.A.,Villen, J.,Maly, D.J. Affinity-Based Probes Based on Type II Kinase Inhibitors. J.Am.Chem.Soc., 134:19017-19025, 2012 Cited by PubMed: 23088519DOI: 10.1021/ja306035v PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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