4EQU

Human STK-10 (LOK) kinase domain in DFG-out conformation with inhibitor DSA-7

Summary for 4EQU

Entry DOI	10.2210/pdb4equ/pdb
Descriptor	Serine/threonine-protein kinase 10, N-{3-[(3-{4-[(4-methoxyphenyl)amino]-1,3,5-triazin-2-yl}pyridin-2-yl)amino]-4-methylphenyl}-3-(trifluoromethyl)benzamide, CALCIUM ION, ... (5 entities in total)
Functional Keywords	serine/threonine kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cell membrane; Peripheral membrane protein: O94804
Total number of polymer chains	2
Total formula weight	70178.98
Authors	Merritt, E.A.,Larson, E.T. (deposition date: 2012-04-19, release date: 2012-11-07, Last modification date: 2012-12-19)
Primary citation	Ranjitkar, P.,Perera, B.G.,Swaney, D.L.,Hari, S.B.,Larson, E.T.,Krishnamurty, R.,Merritt, E.A.,Villen, J.,Maly, D.J. Affinity-Based Probes Based on Type II Kinase Inhibitors. J.Am.Chem.Soc., 134:19017-19025, 2012 Cited by PubMed: 23088519 DOI: 10.1021/ja306035v PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation