4EQU
Human STK-10 (LOK) kinase domain in DFG-out conformation with inhibitor DSA-7
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Serine/threonine-protein kinase 10 | polymer | 302 | 34298.6 | 2 | UniProt (O94804) Pfam (PF00069) In PDB | Homo sapiens (human) | Lymphocyte-oriented kinase |
| 2 | A, B | N-{3-[(3-{4-[(4-methoxyphenyl)amino]-1,3,5-triazin-2-yl}pyridin-2-yl)amino]-4-methylphenyl}-3-(trifluoromethyl)benzamide | non-polymer | 571.6 | 2 | Chemie (G6I) | |||
| 3 | A, B | CALCIUM ION | non-polymer | 40.1 | 5 | Chemie (CA) | |||
| 4 | B | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 1 | Chemie (1PE) | |||
| 5 | water | water | 18.0 | 81 | Chemie (HOH) |
Sequence modifications
A, B: 18 - 317 (UniProt: O94804)
| PDB | External Database | Details |
|---|---|---|
| Ser 16 | - | EXPRESSION TAG |
| Met 17 | - | EXPRESSION TAG |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 68597.2 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1581.8 | |
| All* | Total formula weight | 70179.0 |
