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PDB: 152 件
4GTA
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T. Maritima FDTS with FAD, dUMP, and Folinic Acid
分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Mathews, I.I, Lesley, S.A, Kohen, A.
登録日2012-08-28
公開日2012-10-17
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Folate binding site of flavin-dependent thymidylate synthase.
Proc.Natl.Acad.Sci.USA, 109, 2012
4GTB
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T. Maritima FDTS with FAD, dUMP, and Raltitrexed.
分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Mathews, I.I, Lesley, S.A, Kohen, A.
登録日2012-08-28
公開日2012-10-17
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Folate binding site of flavin-dependent thymidylate synthase.
Proc.Natl.Acad.Sci.USA, 109, 2012
4GTL
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T. Maritima FDTS (R174K mutant) with FAD
分子名称: FLAVIN-ADENINE DINUCLEOTIDE, Thymidylate synthase thyX
著者Mathews, I.I, Lesley, S.A, Kohen, A.
登録日2012-08-28
公開日2012-10-17
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.17 Å)
主引用文献Folate binding site of flavin-dependent thymidylate synthase.
Proc.Natl.Acad.Sci.USA, 109, 2012
3RGG
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BU of 3rgg by Molmil
Crystal structure of Treponema denticola PurE bound to AIR
分子名称: 5-AMINOIMIDAZOLE RIBONUCLEOTIDE, Phosphoribosylaminoimidazole carboxylase, PurE protein
著者Mathews, I.I, Starks, C.M, Kappock, T.J.
登録日2011-04-08
公開日2011-05-18
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献Treponema denticola PurE Is a Bacterial AIR Carboxylase.
Biochemistry, 50, 2011
3RG8
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Crystal structure of Treponema denticola PurE
分子名称: 1,2-ETHANEDIOL, Phosphoribosylaminoimidazole carboxylase, PurE protein
著者Mathews, I.I, Starks, C.M, Kappock, T.J.
登録日2011-04-07
公開日2011-05-18
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.74 Å)
主引用文献Treponema denticola PurE Is a Bacterial AIR Carboxylase.
Biochemistry, 50, 2011
8EUA
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BU of 8eua by Molmil
Structure of SARS-CoV2 PLpro bound to a covalent inhibitor
分子名称: Papain-like protease nsp3, SULFATE ION, ZINC ION, ...
著者Mathews, I.I, Pokhrel, S, Wakatsuki, S.
登録日2022-10-18
公開日2023-04-05
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Potent and selective covalent inhibition of the papain-like protease from SARS-CoV-2.
Nat Commun, 14, 2023
7SEH
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BU of 7seh by Molmil
Glucose-6-phosphate 1-dehydrogenase (K403QdLtL)
分子名称: Glucose-6-phosphate 1-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Mathews, I.I, Garcia, A.A, Wakatsuki, S, Mochly-Rosen, D.
登録日2021-09-30
公開日2022-08-17
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Stabilization of glucose-6-phosphate dehydrogenase oligomers enhances catalytic activity and stability of clinical variants.
J.Biol.Chem., 298, 2022
7SEI
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Glucose-6-phosphate 1-dehydrogenase (K403Q)
分子名称: Glucose-6-phosphate 1-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Mathews, I.I, Garcia, A.A, Wakatsuki, S, Mochly-Rosen, D.
登録日2021-09-30
公開日2022-08-17
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.65 Å)
主引用文献Stabilization of glucose-6-phosphate dehydrogenase oligomers enhances catalytic activity and stability of clinical variants.
J.Biol.Chem., 298, 2022
7SMJ
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BU of 7smj by Molmil
F2N structure, protein design with deep learning
分子名称: AI-designed TIM-barrel F2N
著者Mathews, I.I, Anand-Achim, N, Huang, P.
登録日2021-10-26
公開日2022-03-16
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献Protein sequence design with a learned potential.
Nat Commun, 13, 2022
7T2V
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BU of 7t2v by Molmil
SARS CoV2 Mpro C145S mutant
分子名称: 3C-Like Protease
著者Mathews, I.I, Hameedi, M.A, Wakatsuki, S.
登録日2021-12-06
公開日2022-09-14
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.47 Å)
主引用文献Structural and functional characterization of NEMO cleavage by SARS-CoV-2 3CLpro.
Nat Commun, 13, 2022
7T2T
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SARS-CoV2 Mpro native form
分子名称: 3C-like proteinase
著者Mathews, I.I, Hameedi, M.A, Wakatsuki, S.
登録日2021-12-06
公開日2022-09-14
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Structural and functional characterization of NEMO cleavage by SARS-CoV-2 3CLpro.
Nat Commun, 13, 2022
6MLK
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Structure of Thioesterase from DEBS with a thioesterase-specific antibody
分子名称: 6-deoxyerythronolide-B synthase EryA3, modules 5 and 6, CHLORIDE ION, ...
著者Mathews, I.I, Li, X, Khosla, C.
登録日2018-09-27
公開日2018-10-17
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Discovery and Characterization of a Thioesterase-Specific Monoclonal Antibody That Recognizes the 6-Deoxyerythronolide B Synthase.
Biochemistry, 57, 2018
1D7A
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BU of 1d7a by Molmil
CRYSTAL STRUCTURE OF E. COLI PURE-MONONUCLEOTIDE COMPLEX.
分子名称: 5-AMINOIMIDAZOLE RIBONUCLEOTIDE, PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE
著者Mathews, I.I, Kappock, T.J, Stubbe, J, Ealick, S.E.
登録日1999-10-16
公開日1999-12-03
最終更新日2021-11-03
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of Escherichia coli PurE, an unusual mutase in the purine biosynthetic pathway.
Structure Fold.Des., 7, 1999
4RZM
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BU of 4rzm by Molmil
Crystal structure of the Lsd19-lasalocid A complex
分子名称: CHLORIDE ION, Epoxide hydrolase LasB, FORMIC ACID, ...
著者Mathews, I.I, Hotta, K, Chen, X, Kim, C.-Y.
登録日2014-12-22
公開日2015-01-21
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.33 Å)
主引用文献Epoxide hydrolase-lasalocid a structure provides mechanistic insight into polyether natural product biosynthesis.
J.Am.Chem.Soc., 137, 2015
1O2A
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BU of 1o2a by Molmil
Crystal structure of Thymidylate Synthase Complementing Protein (TM0449) from Thermotoga maritima with FAD at 1.8 A resolution
分子名称: FLAVIN-ADENINE DINUCLEOTIDE, Thymidylate synthase thyX
著者Mathews, I.I, Deacon, A.M, Canaves, J.M, McMullan, D, Lesley, S.A, Agarwalla, S, Kuhn, P, Joint Center for Structural Genomics (JCSG)
登録日2003-02-18
公開日2003-06-24
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Functional Analysis of Substrate and Cofactor Complex Structures of a Thymidylate Synthase-Complementing Protein
Structure, 11, 2003
1O27
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BU of 1o27 by Molmil
Crystal structure of Thymidylate Synthase Complementing Protein (TM0449) from Thermotoga maritima with FAD and BrdUMP at 2.3 A resolution
分子名称: 5-BROMO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE, Thymidylate synthase thyX
著者Mathews, I.I, Deacon, A.M, Canaves, J.M, McMullan, D, Lesley, S.A, Agarwalla, S, Kuhn, P, Joint Center for Structural Genomics (JCSG)
登録日2003-02-18
公開日2003-06-24
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Functional Analysis of Substrate and Cofactor Complex Structures of a Thymidylate Synthase-Complementing Protein
Structure, 11, 2003
1O29
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Crystal structure of Thymidylate Synthase Complementing Protein (TM0449) from Thermotoga maritima with FAD and FdUMP at 2.0 A resolution
分子名称: 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE, Thymidylate synthase thyX
著者Mathews, I.I, Deacon, A.M, Canaves, J.M, McMullan, D, Lesley, S.A, Agarwalla, S, Kuhn, P, Joint Center for Structural Genomics (JCSG)
登録日2003-02-18
公開日2003-06-24
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Functional Analysis of Substrate and Cofactor Complex Structures of a Thymidylate Synthase-Complementing Protein
Structure, 11, 2003
1O26
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Crystal structure of Thymidylate Synthase Complementing Protein (TM0449) from Thermotoga maritima with FAD and dUMP at 1.6 A resolution
分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE, TRIETHYLENE GLYCOL, ...
著者Mathews, I.I, Deacon, A.M, Canaves, J.M, McMullan, D, Lesley, S.A, Agarwalla, S, Kuhn, P, Joint Center for Structural Genomics (JCSG)
登録日2003-02-18
公開日2003-06-24
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Functional Analysis of Substrate and Cofactor Complex Structures of a Thymidylate Synthase-Complementing Protein
Structure, 11, 2003
1O2B
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BU of 1o2b by Molmil
Crystal structure of Thymidylate Synthase Complementing Protein (TM0449) from Thermotoga maritima with FAD and PO4 at 2.45 A resolution
分子名称: FLAVIN-ADENINE DINUCLEOTIDE, PHOSPHATE ION, Thymidylate synthase thyX
著者Mathews, I.I, Deacon, A.M, Canaves, J.M, McMullan, D, Lesley, S.A, Agarwalla, S, Kuhn, P, Joint Center for Structural Genomics (JCSG)
登録日2003-02-18
公開日2003-06-24
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Functional Analysis of Substrate and Cofactor Complex Structures of a Thymidylate Synthase-Complementing Protein
Structure, 11, 2003
1O25
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Crystal structure of Thymidylate Synthase Complementing Protein (TM0449) from Thermotoga maritima with dUMP at 2.4 A resolution
分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Thymidylate synthase thyX
著者Mathews, I.I, Deacon, A.M, Canaves, J.M, McMullan, D, Lesley, S.A, Agarwalla, S, Kuhn, P, Joint Center for Structural Genomics (JCSG)
登録日2003-02-20
公開日2003-06-24
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Functional Analysis of Substrate and Cofactor Complex Structures of a Thymidylate Synthase-Complementing Protein
Structure, 11, 2003
1O24
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BU of 1o24 by Molmil
Crystal structure of Thymidylate Synthase Complementing Protein (TM0449) from Thermotoga maritima at 2.0 A resolution
分子名称: Thymidylate synthase thyX
著者Mathews, I.I, Deacon, A.M, Canaves, J.M, McMullan, D, Lesley, S.A, Agarwalla, S, Kuhn, P, Joint Center for Structural Genomics (JCSG)
登録日2003-02-18
公開日2003-06-24
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Functional Analysis of Substrate and Cofactor Complex Structures of a Thymidylate Synthase-Complementing Protein
Structure, 11, 2003
1O28
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BU of 1o28 by Molmil
Crystal structure of Thymidylate Synthase Complementing Protein (TM0449) from Thermotoga maritima with FdUMP at 2.1 A resolution
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, TRIETHYLENE GLYCOL, ...
著者Mathews, I.I, Deacon, A.M, Canaves, J.M, McMullan, D, Lesley, S.A, Agarwalla, S, Kuhn, P, Joint Center for Structural Genomics (JCSG)
登録日2003-02-18
公開日2003-06-24
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Functional Analysis of Substrate and Cofactor Complex Structures of a Thymidylate Synthase-Complementing Protein
Structure, 11, 2003
1QCZ
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BU of 1qcz by Molmil
CRYSTAL STRUCTURE OF E. COLI PURE, AN UNUSUAL MUTASE THAT CATALYZES THE CONVERSION OF N5-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDE (N5-CAIR) TO 4-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDE (CAIR) IN THE PURINE BIOSYNTHETIC PATHWAY
分子名称: N5-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDE MUTASE
著者Ealick, S.E, Mathews, I.I.
登録日1999-05-10
公開日1999-11-10
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Crystal structure of Escherichia coli PurE, an unusual mutase in the purine biosynthetic pathway.
Structure Fold.Des., 7, 1999
8T3P
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Crystal structure of MonC1 (a flavin-dependent monooxygenase)
分子名称: CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, MonCI
著者Wang, Q, Mathews, I.I, Kim, C.Y.
登録日2023-06-07
公開日2023-11-08
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Triepoxide formation by a flavin-dependent monooxygenase in monensin biosynthesis.
Nat Commun, 14, 2023
1HLT
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BU of 1hlt by Molmil
THE STRUCTURE OF A NONADECAPEPTIDE OF THE FIFTH EGF DOMAIN OF THROMBOMODULIN COMPLEXED WITH THROMBIN
分子名称: ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ...
著者Tulinsky, A, Mathews, I.I.
登録日1994-08-28
公開日1994-12-20
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structure of a nonadecapeptide of the fifth EGF domain of thrombomodulin complexed with thrombin.
Biochemistry, 33, 1994

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