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PDB: 43 件
6GJW
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BU of 6gjw by Molmil
Structure of XIAP-BIR1 domain in complex with an NF023 analog
分子名称: 4-[[3-[[3-[(4,8-disulfonatonaphthalen-1-yl)carbamoyl]phenyl]carbamoylamino]phenyl]carbonylamino]naphthalene-1,5-disulfonate, E3 ubiquitin-protein ligase XIAP, ZINC ION
著者Sorrentino, L, Cossu, F, Malkoc, B, Zaffaroni, M, Milani, M, Mastrangelo, E.
登録日2018-05-17
公開日2019-05-29
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure-Activity Relationship of NF023 Derivatives Binding to XIAP-BIR1.
Chemistryopen, 8, 2019
6H1F
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Structure of the nanobody-stabilized gelsolin D187N variant (second domain)
分子名称: Gelsolin, THIOCYANATE ION, gelsolin nanobody, ...
著者Hassan, A, Milani, M, Mastrangelo, E, de Rosa, M.
登録日2018-07-11
公開日2019-01-23
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Nanobody interaction unveils structure, dynamics and proteotoxicity of the Finnish-type amyloidogenic gelsolin variant.
Biochim Biophys Acta Mol Basis Dis, 1865, 2019
6G49
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Crystal structure of the periplasmic domain of TgpA from Pseudomonas aeruginosa
分子名称: CHLORIDE ION, PHOSPHATE ION, Protein-glutamine gamma-glutamyltransferase
著者Milani, M, Mastrangelo, E, Uruburu, M.
登録日2018-03-27
公開日2019-04-10
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural and functional characterization of TgpA, a critical protein for the viability of Pseudomonas aeruginosa.
J.Struct.Biol., 205, 2019
4O4R
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BU of 4o4r by Molmil
Murine Norovirus RdRp in complex with PPNDS
分子名称: 3-[(E)-{4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]pyridin-2-yl}diazenyl]-7-nitronaphthalene-1,5-disulfonic acid, RNA-dependent-RNA-polymerase, SULFATE ION
著者Croci, R, Tarantino, D, Milani, M, Pezzullo, M, Bolognesi, M, Mastrangelo, E.
登録日2013-12-19
公開日2014-11-05
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献PPNDS inhibits murine Norovirus RNA-dependent RNA-polymerase mimicking two RNA stacking bases.
Febs Lett., 588, 2014
4NRU
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Murine Norovirus RNA-dependent-RNA-polymerase in complex with Compound 6, a suramin derivative
分子名称: 4-({4-methyl-3-[(3-nitrobenzoyl)amino]benzoyl}amino)naphthalene-1,5-disulfonic acid, MAGNESIUM ION, RNA dependent RNA polymerase
著者Milani, M, Croci, R, Pezzullo, M, Tarantino, D, Mastrangelo, E, Bolognesi, M.
登録日2013-11-27
公開日2014-10-15
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural bases of norovirus RNA dependent RNA polymerase inhibition by novel suramin-related compounds.
Plos One, 9, 2014
4MTZ
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Structure of XIAP-BIR1 in complex with NF023
分子名称: 8-({3-[({3-[(4,6,8-trisulfonaphthalen-1-yl)carbamoyl]phenyl}carbamoyl)amino]benzoyl}amino)naphthalene-1,3,5-trisulfonic acid, E3 ubiquitin-protein ligase XIAP, SULFATE ION, ...
著者Cossu, F, Milani, M, Grassi, S, Mastrangelo, E, Bolognesi, M.
登録日2013-09-20
公開日2014-09-24
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Protein-protein interactions in nfkb pathway: novel tools to promote apoptosis in cancer therapy
To be Published
4OXC
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Crystal structure of XIAP BIR1 domain
分子名称: E3 ubiquitin-protein ligase XIAP, ZINC ION
著者Milani, M, Cossu, F, Mastrangelo, E.
登録日2014-02-05
公開日2015-02-11
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献NF023 binding to XIAP-BIR1: Searching drugs for regulation of the NF-kappa B pathway.
Proteins, 83, 2015
4NRT
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Human Norovirus polymerase bound to Compound 6 (suramin derivative)
分子名称: 4-({4-methyl-3-[(3-nitrobenzoyl)amino]benzoyl}amino)naphthalene-1,5-disulfonic acid, hNV-RdRp
著者Croci, R, Pezzullo, M, Tarantino, D, Mastrangelo, E, Milani, M, Bolognesi, M.
登録日2013-11-27
公開日2014-10-15
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.022 Å)
主引用文献Structural bases of norovirus RNA dependent RNA polymerase inhibition by novel suramin-related compounds.
Plos One, 9, 2014
3ELY
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Wesselsbron virus Methyltransferase in complex with AdoHcy
分子名称: DI(HYDROXYETHYL)ETHER, Methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, ...
著者Bollati, M, Milani, M, Ricagno, S, Mastrangelo, E, Bolognesi, M.
登録日2008-09-23
公開日2008-11-18
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus
J.Mol.Biol., 385, 2009
3EMB
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Wesselsbron virus Methyltransferase in complex with AdoMet and 7MeGpppG
分子名称: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, Methyltransferase, S-ADENOSYLMETHIONINE, ...
著者Bollati, M, Ricagno, S, Milani, M, Mastrangelo, E, Bolognesi, M.
登録日2008-09-24
公開日2008-11-18
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus
J.Mol.Biol., 385, 2009
3ELW
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Wesselsbron virus Methyltransferase in complex with AdoMet and GpppG
分子名称: DIGUANOSINE-5'-TRIPHOSPHATE, Methyltransferase, S-ADENOSYLMETHIONINE, ...
著者Bollati, M, Ricagno, S, Milani, M, Mastrangelo, E, Bolognesi, M.
登録日2008-09-23
公開日2008-11-18
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus
J.Mol.Biol., 385, 2009
3CM2
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BU of 3cm2 by Molmil
Crystal Structure of XIAP BIR3 domain in complex with a Smac-mimetic compound, Smac010
分子名称: (3S,6S,7R,9aS)-6-{[(2S)-2-aminobutanoyl]amino}-7-(aminomethyl)-N-(diphenylmethyl)-5-oxooctahydro-1H-pyrrolo[1,2-a]azepine-3-carboxamide, Baculoviral IAP repeat-containing protein 4, ZINC ION
著者Cossu, F, Mastrangelo, E, Milani, M.
登録日2008-03-20
公開日2008-10-28
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Targeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo[5.3.0]alkane smac mimetics. Structure, activity, and recognition principles.
J.Mol.Biol., 384, 2008
3ELU
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BU of 3elu by Molmil
Wesselsbron virus Methyltransferase in complex with AdoMet
分子名称: Methyltransferase, S-ADENOSYLMETHIONINE, SULFATE ION
著者Bollati, M, Ricagno, S, Milani, M, Mastrangelo, E, Bolognesi, M.
登録日2008-09-23
公開日2008-11-18
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus
J.Mol.Biol., 385, 2009
3EMD
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BU of 3emd by Molmil
Wesselsbron virus Methyltransferase in complex with Sinefungin and 7MeGpppA
分子名称: P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE, SINEFUNGIN, SULFATE ION, ...
著者Bollati, M, Milani, M, Ricagno, S, Mastrangelo, E, Bolognesi, M.
登録日2008-09-24
公開日2008-11-18
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus
J.Mol.Biol., 385, 2009
3ELD
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BU of 3eld by Molmil
Wesselsbron methyltransferase in complex with Sinefungin
分子名称: Methyltransferase, SINEFUNGIN, SULFATE ION
著者Bollati, M, Milani, M, Mastrangelo, E, Ricagno, S, Bolognesi, M.
登録日2008-09-22
公開日2008-11-18
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus
J.Mol.Biol., 385, 2009
3CLX
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BU of 3clx by Molmil
Crystal structure of XIAP BIR3 domain in complex with a Smac-mimetic compound, Smac005
分子名称: (3S,6S,7S,9aS)-6-{[(2S)-2-aminobutanoyl]amino}-N-(diphenylmethyl)-7-(hydroxymethyl)-5-oxooctahydro-1H-pyrrolo[1,2-a]azepine-3-carboxamide, Baculoviral IAP repeat-containing protein 4, ZINC ION
著者Milani, M, Mastrangelo, E, Cossu, F.
登録日2008-03-20
公開日2008-10-28
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Targeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo[5.3.0]alkane smac mimetics. Structure, activity, and recognition principles.
J.Mol.Biol., 384, 2008
3EYL
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BU of 3eyl by Molmil
Crystal structure of XIAP BIR3 domain in complex with a Smac-mimetic compound
分子名称: (3S,6S,7R,9aS)-6-{[(2S)-2-aminobutanoyl]amino}-7-(2-aminoethyl)-N-(diphenylmethyl)-5-oxooctahydro-1H-pyrrolo[1,2-a]azepine-3-carboxamide, Baculoviral IAP repeat-containing protein 4, ZINC ION
著者Cossu, F, Milani, M, Mastrangelo, E, Bolognesi, M.
登録日2008-10-21
公開日2008-11-25
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Designing Smac-mimetics as antagonists of XIAP, cIAP1, and cIAP2.
Biochem.Biophys.Res.Commun., 378, 2009
3GCZ
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Yokose virus Methyltransferase in complex with AdoMet
分子名称: GLYCEROL, Polyprotein, S-ADENOSYLMETHIONINE, ...
著者Bollati, M, Milani, M, Mastrangelo, E, Bolognesi, M, Structural Proteomics in Europe (SPINE)
登録日2009-02-23
公開日2009-03-24
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal structure of a methyltransferase from a no-known-vector Flavivirus
Biochem.Biophys.Res.Commun., 382, 2009
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