3CM2
Crystal Structure of XIAP BIR3 domain in complex with a Smac-mimetic compound, Smac010
Summary for 3CM2
Entry DOI | 10.2210/pdb3cm2/pdb |
Related | 1G73 3CLX |
Descriptor | Baculoviral IAP repeat-containing protein 4, ZINC ION, (3S,6S,7R,9aS)-6-{[(2S)-2-aminobutanoyl]amino}-7-(aminomethyl)-N-(diphenylmethyl)-5-oxooctahydro-1H-pyrrolo[1,2-a]azepine-3-carboxamide, ... (4 entities in total) |
Functional Keywords | zinc-finger, apoptosis, cytoplasm, ligase, metal-binding, phosphoprotein, polymorphism, protease inhibitor, thiol protease inhibitor, ubl conjugation, ubl conjugation pathway |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P98170 |
Total number of polymer chains | 10 |
Total formula weight | 152323.74 |
Authors | Cossu, F.,Mastrangelo, E.,Milani, M. (deposition date: 2008-03-20, release date: 2008-10-28, Last modification date: 2023-08-30) |
Primary citation | Mastrangelo, E.,Cossu, F.,Milani, M.,Sorrentino, G.,Lecis, D.,Delia, D.,Manzoni, L.,Drago, C.,Seneci, P.,Scolastico, C.,Rizzo, V.,Bolognesi, M. Targeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo[5.3.0]alkane smac mimetics. Structure, activity, and recognition principles. J.Mol.Biol., 384:673-689, 2008 Cited by PubMed: 18851976DOI: 10.1016/j.jmb.2008.09.064 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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