3CLX

Crystal structure of XIAP BIR3 domain in complex with a Smac-mimetic compound, Smac005

Summary for 3CLX

Entry DOI	10.2210/pdb3clx/pdb
Related	1G73 3CM2
Descriptor	Baculoviral IAP repeat-containing protein 4, ZINC ION, (3S,6S,7S,9aS)-6-{[(2S)-2-aminobutanoyl]amino}-N-(diphenylmethyl)-7-(hydroxymethyl)-5-oxooctahydro-1H-pyrrolo[1,2-a]azepine-3-carboxamide, ... (4 entities in total)
Functional Keywords	zinc-finger, apoptosis, cytoplasm, ligase, metal-binding, phosphoprotein, polymorphism, protease inhibitor, thiol protease inhibitor, ubl conjugation, ubl conjugation pathway
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: P98170
Total number of polymer chains	4
Total formula weight	61918.66
Authors	Milani, M.,Mastrangelo, E.,Cossu, F. (deposition date: 2008-03-20, release date: 2008-10-28, Last modification date: 2023-08-30)
Primary citation	Mastrangelo, E.,Cossu, F.,Milani, M.,Sorrentino, G.,Lecis, D.,Delia, D.,Manzoni, L.,Drago, C.,Seneci, P.,Scolastico, C.,Rizzo, V.,Bolognesi, M. Targeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo[5.3.0]alkane smac mimetics. Structure, activity, and recognition principles. J.Mol.Biol., 384:673-689, 2008 Cited by PubMed: 18851976 DOI: 10.1016/j.jmb.2008.09.064 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation