4NRT

Human Norovirus polymerase bound to Compound 6 (suramin derivative)

Summary for 4NRT

Entry DOI	10.2210/pdb4nrt/pdb
Descriptor	hNV-RdRp, 4-({4-methyl-3-[(3-nitrobenzoyl)amino]benzoyl}amino)naphthalene-1,5-disulfonic acid (3 entities in total)
Functional Keywords	rna dependent rna polymerase, viral protein-transcription inhibitor complex, viral protein/transcription inhibitor
Biological source	Norwalk-like virus
Total number of polymer chains	1
Total formula weight	59243.32
Authors	Croci, R.,Pezzullo, M.,Tarantino, D.,Mastrangelo, E.,Milani, M.,Bolognesi, M. (deposition date: 2013-11-27, release date: 2014-10-15, Last modification date: 2023-09-20)
Primary citation	Croci, R.,Pezzullo, M.,Tarantino, D.,Milani, M.,Tsay, S.C.,Sureshbabu, R.,Tsai, Y.J.,Mastrangelo, E.,Rohayem, J.,Bolognesi, M.,Hwu, J.R. Structural bases of norovirus RNA dependent RNA polymerase inhibition by novel suramin-related compounds. Plos One, 9:e91765-e91765, 2014 Cited by PubMed: 24622391 DOI: 10.1371/journal.pone.0091765 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.022 Å)

Structure validation