3EYL

Crystal structure of XIAP BIR3 domain in complex with a Smac-mimetic compound

Summary for 3EYL

Entry DOI	10.2210/pdb3eyl/pdb
Related	1g73 3clx 3cm2 3cm7
Descriptor	Baculoviral IAP repeat-containing protein 4, ZINC ION, (3S,6S,7R,9aS)-6-{[(2S)-2-aminobutanoyl]amino}-7-(2-aminoethyl)-N-(diphenylmethyl)-5-oxooctahydro-1H-pyrrolo[1,2-a]azepine-3-carboxamide, ... (4 entities in total)
Functional Keywords	apoptosis, smac-mimetics, zinc-finger, ligase, metal-binding, phosphoprotein, protease inhibitor, thiol protease inhibitor, ubl conjugation pathway
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P98170
Total number of polymer chains	2
Total formula weight	29387.40
Authors	Cossu, F.,Milani, M.,Mastrangelo, E.,Bolognesi, M. (deposition date: 2008-10-21, release date: 2008-11-25, Last modification date: 2023-09-06)
Primary citation	Cossu, F.,Mastrangelo, E.,Milani, M.,Sorrentino, G.,Lecis, D.,Delia, D.,Manzoni, L.,Seneci, P.,Scolastico, C.,Bolognesi, M. Designing Smac-mimetics as antagonists of XIAP, cIAP1, and cIAP2. Biochem.Biophys.Res.Commun., 378:162-167, 2009 Cited by PubMed: 18992220 DOI: 10.1016/j.bbrc.2008.10.139 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation