5J8F
| Human MOF K274P crystal structure | Descriptor: | CHLORIDE ION, Histone acetyltransferase KAT8, ZINC ION | Authors: | McCullough, C.E, Marmorstein, R. | Deposit date: | 2016-04-07 | Release date: | 2016-07-20 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural and Functional Role of Acetyltransferase hMOF K274 Autoacetylation. J.Biol.Chem., 291, 2016
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7TOF
| Structure of G6PD-WT dimer with no symmetry applied | Descriptor: | Glucose-6-phosphate 1-dehydrogenase | Authors: | Wei, X, Marmorstein, R. | Deposit date: | 2022-01-24 | Release date: | 2022-09-14 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Allosteric role of a structural NADP + molecule in glucose-6-phosphate dehydrogenase activity. Proc.Natl.Acad.Sci.USA, 119, 2022
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7SNH
| Structure of G6PD-D200N tetramer bound to NADP+ | Descriptor: | Glucose-6-phosphate 1-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Wei, X, Marmorstein, R. | Deposit date: | 2021-10-28 | Release date: | 2022-07-13 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.2 Å) | Cite: | Allosteric role of a structural NADP + molecule in glucose-6-phosphate dehydrogenase activity. Proc.Natl.Acad.Sci.USA, 119, 2022
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7SNF
| Structure of G6PD-WT dimer | Descriptor: | Glucose-6-phosphate 1-dehydrogenase | Authors: | Wei, X, Marmorstein, R. | Deposit date: | 2021-10-28 | Release date: | 2022-07-13 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Allosteric role of a structural NADP + molecule in glucose-6-phosphate dehydrogenase activity. Proc.Natl.Acad.Sci.USA, 119, 2022
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5JRQ
| BRAFV600E Kinase Domain In Complex with Chemically Linked Vemurafenib Inhibitor VEM-6-VEM | Descriptor: | DIMETHYL SULFOXIDE, GLYCEROL, N-{2,4-difluoro-3-[5-(4-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]phenyl}propane-1-sulfonamide, ... | Authors: | Grasso, M.J, Marmorstein, R. | Deposit date: | 2016-05-06 | Release date: | 2016-09-14 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.287 Å) | Cite: | Chemically Linked Vemurafenib Inhibitors Promote an Inactive BRAF(V600E) Conformation. Acs Chem.Biol., 11, 2016
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6VP9
| Cryo-EM structure of human NatB complex | Descriptor: | CARBOXYMETHYL COENZYME *A, MDVFM peptide, N-alpha-acetyltransferase 20, ... | Authors: | Deng, S, Marmorstein, R. | Deposit date: | 2020-02-02 | Release date: | 2020-09-23 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.46 Å) | Cite: | Molecular basis for N-terminal alpha-synuclein acetylation by human NatB. Elife, 9, 2020
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7UAL
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7UC2
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1CS3
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2FQ3
| Structure and function of the SWIRM domain, a conserved protein module found in chromatin regulatory complexes | Descriptor: | Transcription regulatory protein SWI3 | Authors: | Da, G, Lenkart, J, Zhao, K, Shiekhattar, R, Cairns, B.R, Marmorstein, R. | Deposit date: | 2006-01-17 | Release date: | 2006-02-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structure and function of the SWIRM domain, a conserved protein module found in chromatin regulatory complexes Proc.Natl.Acad.Sci.Usa, 103, 2006
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3Q33
| Structure of the Rtt109-AcCoA/Vps75 Complex and Implications for Chaperone-Mediated Histone Acetylation | Descriptor: | 1,2-ETHANEDIOL, ACETYL COENZYME *A, HISTONE H3, ... | Authors: | Tang, Y, Yuan, H, Meeth, K, Marmorstein, R. | Deposit date: | 2010-12-21 | Release date: | 2011-02-02 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of the Rtt109-AcCoA/Vps75 Complex and Implications for Chaperone-Mediated Histone Acetylation. Structure, 19, 2011
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1DUX
| ELK-1/DNA STRUCTURE REVEALS HOW RESIDUES DISTAL FROM DNA-BINDING SURFACE AFFECT DNA-RECOGNITION | Descriptor: | DNA (5'-D(*AP*CP*AP*CP*TP*TP*CP*CP*GP*GP*TP*CP*A)-3'), DNA (5'-D(*TP*GP*AP*CP*CP*GP*GP*AP*AP*GP*TP*GP*T)-3'), ETS-DOMAIN PROTEIN ELK-1 | Authors: | Mo, Y, Vaessen, B, Johnston, K, Marmorstein, R. | Deposit date: | 2000-01-19 | Release date: | 2000-04-17 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure of the elk-1-DNA complex reveals how DNA-distal residues affect ETS domain recognition of DNA. Nat.Struct.Biol., 7, 2000
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4LX9
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1S5P
| Structure and substrate binding properties of cobB, a Sir2 homolog protein deacetylase from Eschericia coli. | Descriptor: | HISTONE H4 (RESIDUES 12-19), NAD-dependent deacetylase, ZINC ION | Authors: | Zhao, K, Chai, X, Marmorstein, R. | Deposit date: | 2004-01-21 | Release date: | 2004-03-23 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Structure and Substrate Binding Properties of cobB, a Sir2 Homolog Protein Deacetylase from Eschericia coli. J.Mol.Biol., 337, 2004
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3FY0
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3FXZ
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1O9K
| Crystal structure of the retinoblastoma tumour suppressor protein bound to E2F peptide | Descriptor: | RETINOBLASTOMA-ASSOCIATED PROTEIN, TRANSCRIPTION FACTOR E2F1 | Authors: | Xiao, B, Spencer, J, Clements, A, Ali-Khan, N, Mittnacht, S, Broceno, C, Burghammer, M, Perrakis, A, Marmorstein, R, Gamblin, S.J. | Deposit date: | 2002-12-16 | Release date: | 2003-03-06 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal Structure of the Retinoblastoma Tumor Suppressor Protein Bound to E2F and the Molecular Basis of its Regulation Proc.Natl.Acad.Sci.USA, 100, 2003
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7L1K
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4RLO
| Human p70s6k1 with ruthenium-based inhibitor EM5 | Descriptor: | CHLORIDE ION, DIMETHYL SULFOXIDE, GLYCEROL, ... | Authors: | Domsic, J.F, Barber-Rotenberg, J, Salami, J, Qin, J, Marmorstein, R. | Deposit date: | 2014-10-17 | Release date: | 2015-01-21 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.527 Å) | Cite: | Development of Organometallic S6K1 Inhibitors. J.Med.Chem., 58, 2015
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3TOA
| Human MOF crystal structure with active site lysine partially acetylated | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, ZINC ION, ... | Authors: | Yuan, H, Ding, E.C, Marmorstein, R. | Deposit date: | 2011-09-04 | Release date: | 2011-11-09 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (3.004 Å) | Cite: | MYST protein acetyltransferase activity requires active site lysine autoacetylation. Embo J., 31, 2011
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3TO6
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3TO7
| Crystal structure of yeast Esa1 HAT domain bound to coenzyme A with active site lysine acetylated | Descriptor: | CACODYLIC ACID, COENZYME A, GLYCEROL, ... | Authors: | Yuan, H, Ding, E.C, Marmorstein, R. | Deposit date: | 2011-09-04 | Release date: | 2011-11-09 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | MYST protein acetyltransferase activity requires active site lysine autoacetylation. Embo J., 31, 2011
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3TOB
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3TO9
| Crystal structure of yeast Esa1 E338Q HAT domain bound to coenzyme A with active site lysine acetylated | Descriptor: | 1,2-ETHANEDIOL, CACODYLIC ACID, COENZYME A, ... | Authors: | Yuan, H, Ding, E.C, Marmorstein, R. | Deposit date: | 2011-09-04 | Release date: | 2011-11-09 | Last modified: | 2012-01-18 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | MYST protein acetyltransferase activity requires active site lysine autoacetylation. Embo J., 31, 2011
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3CO7
| Crystal Structure of FoxO1 DBD Bound to DBE2 DNA | Descriptor: | DNA (5'-D(*DCP*DAP*DAP*DAP*DAP*DTP*DGP*DTP*DAP*DAP*DAP*DCP*DAP*DAP*DGP*DA)-3'), DNA (5'-D(*DTP*DCP*DTP*DTP*DGP*DTP*DTP*DTP*DAP*DCP*DAP*DTP*DTP*DTP*DTP*DG)-3'), Forkhead box protein O1 | Authors: | Brent, M.M, Anand, R, Marmorstein, R. | Deposit date: | 2008-03-27 | Release date: | 2008-09-16 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.91 Å) | Cite: | Structural Basis for DNA Recognition by FoxO1 and Its Regulation by Posttranslational Modification. Structure, 16, 2008
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