3TO6

Crystal structure of yeast Esa1 HAT domain complexed with H4K16CoA bisubstrate inhibitor

Summary for 3TO6

• Entry DOI: 10.2210/pdb3to6/pdb
• Related: 3TO7 3TO9 3TOA 3TOB
• Descriptor: Histone acetyltransferase ESA1, Histone H4, CARBOXYMETHYL COENZYME *A, ... (4 entities in total)
• Functional Keywords: acetyltransferase, autoacetylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Saccharomyces cerevisiae (Baker's yeast); More
• Cellular location: Nucleus: P02309
• Total number of polymer chains: 2
• Total formula weight: 35305.28

Authors

Yuan, H.,Ding, E.C.,Marmorstein, R. (deposition date: 2011-09-04, release date: 2011-11-09, Last modification date: 2023-12-06)

• Primary citation: Yuan, H.,Rossetto, D.,Mellert, H.,Dang, W.,Srinivasan, M.,Johnson, J.,Hodawadekar, S.,Ding, E.C.,Speicher, K.,Abshiru, N.,Perry, R.,Wu, J.,Yang, C.,Zheng, Y.G.,Speicher, D.W.,Thibault, P.,Verreault, A.,Johnson, F.B.,Berger, S.L.,Sternglanz, R.,McMahon, S.B.,Cote, J.,Marmorstein, R.; MYST protein acetyltransferase activity requires active site lysine autoacetylation.; Embo J., 31:58-70, 2011; PubMed: 22020126; DOI: 10.1038/emboj.2011.382

Experimental method

X-RAY DIFFRACTION (2.1 Å)