3TO6

Crystal structure of yeast Esa1 HAT domain complexed with H4K16CoA bisubstrate inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004402	molecular_function	histone acetyltransferase activity
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	BINDING SITE FOR RESIDUE CMC B 600

Chain	Residue
A	HOH3
A	GLN312
A	ARG313
A	MET314
A	GLY315
A	GLY317
A	LYS318
A	GLU338
A	SER342
A	SER348
A	ARG421
A	HOH4
B	HOH52
B	HOH246
B	LYS500
A	HOH48
A	PHE258
A	LEU259
A	ALA303
A	ILE305
A	LEU306
A	THR307

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Functional Information from PROSITE/UniProt

site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
B	GLY498-HIS502

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	DNA_BIND:

Chain	Residue	Details
B	LYS500-LYS504

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:22343720

Chain	Residue	Details
B	LYS496

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:11080160, ECO:0000269|PubMed:15150415, ECO:0000269|PubMed:17289592, ECO:0000269|PubMed:19113941

Chain	Residue	Details
B	LYS500
A	GLN312
A	SER342

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site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Important for catalytic activity => ECO:0000305

Chain	Residue	Details
A	CYS304

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: N6-acetyllysine; by autocatalysis => ECO:0000269|PubMed:22020126

Chain	Residue	Details
A	ALY262

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	2
Details	M-CSA 525

Chain	Residue	Details
A	CYS304	covalently attached, nucleofuge, nucleophile, proton acceptor, proton donor
A	GLU338	activator, proton acceptor, proton donor

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