1MX4
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![BU of 1mx4 by Molmil](/molmil-images/mine/1mx4) | Structure of p18INK4c (F82Q) | Descriptor: | Cyclin-dependent kinase 6 inhibitor | Authors: | Marmorstein, R, Venkataramani, R.N, MacLachlan, T.K, Chai, X, El-Deiry, W.S. | Deposit date: | 2002-10-01 | Release date: | 2002-10-16 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure-based design of p18INK4c proteins with increased thermodynamic stability and cell cycle inhibitory activity J.Biol.Chem., 277, 2002
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1MX2
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![BU of 1mx2 by Molmil](/molmil-images/mine/1mx2) | Structure of F71N mutant of p18INK4c | Descriptor: | Cyclin-dependent kinase 6 inhibitor | Authors: | Marmorstein, R, Venkataramani, R.N, MacLachlan, T.K, Chai, X, El-Deiery, W.S. | Deposit date: | 2002-10-01 | Release date: | 2002-10-16 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structure-based design of p18INK4c proteins with increased thermodynamic stability and cell cycle inhibitory activity J.Biol.Chem., 277, 2002
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1MX6
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![BU of 1mx6 by Molmil](/molmil-images/mine/1mx6) | Structure of p18INK4c (F92N) | Descriptor: | Cyclin-dependent kinase 6 inhibitor | Authors: | Marmorstein, R, Venkataramani, R.N, MacLachlan, T.K, Chai, X, El-Deiry, W.S. | Deposit date: | 2002-10-01 | Release date: | 2002-10-16 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure-based design of p18INK4c proteins with increased thermodynamic stability and cell cycle inhibitory activity J.Biol.Chem., 277, 2002
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4ZBJ
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![BU of 4zbj by Molmil](/molmil-images/mine/4zbj) | UBN1 peptide bound to H3.3/H4/Asf1 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, Histone H3, ... | Authors: | Marmorstein, R, Ricketts, M.D, Tang, Y. | Deposit date: | 2015-04-14 | Release date: | 2015-07-15 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.248 Å) | Cite: | Ubinuclein-1 confers histone H3.3-specific-binding by the HIRA histone chaperone complex. Nat Commun, 6, 2015
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5T53
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![BU of 5t53 by Molmil](/molmil-images/mine/5t53) | MOLECULAR BASIS FOR COHESIN ACETYLATION BY ESTABLISHMENT OF SISTER CHROMATID COHESION N-ACETYLTRANSFERASE ESCO1 | Descriptor: | ACETYL COENZYME *A, N-acetyltransferase ESCO1, ZINC ION | Authors: | Marmorstein, R, Rivera-Colon, Y, Liszczak, G.P, Olia, A.S, Maguire, A. | Deposit date: | 2016-08-30 | Release date: | 2016-11-09 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.699 Å) | Cite: | Molecular Basis for Cohesin Acetylation by Establishment of Sister Chromatid Cohesion N-Acetyltransferase ESCO1. J. Biol. Chem., 291, 2016
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2I32
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2OD7
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![BU of 2od7 by Molmil](/molmil-images/mine/2od7) | Crystal Structure of yHst2 bound to the intermediate analogue ADP-HPD, and and aceylated H4 peptide | Descriptor: | 5'-O-[(S)-{[(S)-{[(2R,3R,4S)-3,4-DIHYDROXYPYRROLIDIN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]ADENOSINE, Acetylated histone H4 peptide, NAD-dependent deacetylase HST2, ... | Authors: | Marmorstein, R.Q, Sanders, B.D. | Deposit date: | 2006-12-21 | Release date: | 2007-02-27 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for nicotinamide inhibition and base exchange in sir2 enzymes. Mol.Cell, 25, 2007
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2OD9
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![BU of 2od9 by Molmil](/molmil-images/mine/2od9) | Structural Basis for Nicotinamide Inhibition and Base Exchange in Sir2 Enzymes | Descriptor: | 5'-O-[(S)-{[(S)-{[(2R,3R,4S)-3,4-DIHYDROXYPYRROLIDIN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]ADENOSINE, H4 peptide, NAD-dependent deacetylase HST2, ... | Authors: | Marmorstein, R, Sanders, B.D. | Deposit date: | 2006-12-21 | Release date: | 2007-02-27 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structural basis for nicotinamide inhibition and base exchange in sir2 enzymes. Mol.Cell, 25, 2007
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2QQF
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![BU of 2qqf by Molmil](/molmil-images/mine/2qqf) | Hst2 bound to ADP-HPD and Acetylated histone H4 | Descriptor: | 5'-O-[(S)-{[(S)-{[(2R,3R,4S)-3,4-DIHYDROXYPYRROLIDIN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]ADENOSINE, Histone H4, NAD-dependent deacetylase HST2, ... | Authors: | Marmorstein, R, Sanders, B.D, Zhao, K, Slama, J. | Deposit date: | 2007-07-26 | Release date: | 2007-10-09 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for nicotinamide inhibition and base exchange in sir2 enzymes. Mol.Cell, 25, 2007
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2QQG
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![BU of 2qqg by Molmil](/molmil-images/mine/2qqg) | Hst2 bound to ADP-HPD, acetyllated histone H4 and nicotinamide | Descriptor: | 5'-O-[(S)-{[(S)-{[(2R,3R,4S)-3,4-DIHYDROXYPYRROLIDIN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]ADENOSINE, Histone H4, NAD-dependent deacetylase HST2, ... | Authors: | Marmorstein, R, Sanders, B, Zhao, K, Slama, J. | Deposit date: | 2007-07-26 | Release date: | 2007-10-09 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structural basis for nicotinamide inhibition and base exchange in sir2 enzymes. Mol.Cell, 25, 2007
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1D66
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![BU of 1d66 by Molmil](/molmil-images/mine/1d66) | DNA RECOGNITION BY GAL4: STRUCTURE OF A PROTEIN/DNA COMPLEX | Descriptor: | CADMIUM ION, DNA (5'-D(*CP*CP*GP*GP*AP*GP*GP*AP*CP*AP*GP*TP*CP*CP*TP*CP*C P*GP*G)-3'), DNA (5'-D(*CP*CP*GP*GP*AP*GP*GP*AP*CP*TP*GP*TP*CP*CP*TP*CP*C P*GP*G)-3'), ... | Authors: | Marmorstein, R, Carey, M, Ptashne, M, Harrison, S.C. | Deposit date: | 1992-03-06 | Release date: | 1992-03-06 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | DNA recognition by GAL4: structure of a protein-DNA complex. Nature, 356, 1992
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1PYI
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![BU of 1pyi by Molmil](/molmil-images/mine/1pyi) | |
2RC4
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![BU of 2rc4 by Molmil](/molmil-images/mine/2rc4) | Crystal Structure of the HAT domain of the human MOZ protein | Descriptor: | ACETYL COENZYME *A, Histone acetyltransferase MYST3, ZINC ION | Authors: | Holbert, M.A, Sikorski, T, Snowflack, D, Marmorstein, R. | Deposit date: | 2007-09-19 | Release date: | 2007-11-13 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The human monocytic leukemia zinc finger histone acetyltransferase domain contains DNA-binding activity implicated in chromatin targeting. J.Biol.Chem., 282, 2007
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5WJD
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![BU of 5wjd by Molmil](/molmil-images/mine/5wjd) | Crystal structure of Naa80 bound to acetyl-CoA | Descriptor: | ACETYL COENZYME *A, CG8481, isoform B, ... | Authors: | Goris, M, Magin, R.S, Marmorstein, R, Arnesen, T. | Deposit date: | 2017-07-21 | Release date: | 2018-03-28 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.001 Å) | Cite: | Structural determinants and cellular environment define processed actin as the sole substrate of the N-terminal acetyltransferase NAA80. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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7MX2
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5ICV
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![BU of 5icv by Molmil](/molmil-images/mine/5icv) | Crystal structure of human NatF (hNaa60) bound to a bisubstrate analogue | Descriptor: | MET-LYS-ALA-VAL-LIG, N-alpha-acetyltransferase 60, [5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)furan-2-yl]methyl (3R)-4-{[3-({(E)-2-[(2,2-dihydroxyethyl)sulfanyl]ethenyl}amino)-3-oxopropyl]amino}-3-hydroxy-2,2-dimethyl-4-oxobutyl dihydrogen diphosphate | Authors: | Stove, S.I, Magin, R.S, Marmorstein, R, Arnesen, T. | Deposit date: | 2016-02-23 | Release date: | 2016-06-22 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.53 Å) | Cite: | Crystal Structure of the Golgi-Associated Human N alpha-Acetyltransferase 60 Reveals the Molecular Determinants for Substrate-Specific Acetylation. Structure, 24, 2016
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2GEQ
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![BU of 2geq by Molmil](/molmil-images/mine/2geq) | Crystal Structure of a p53 Core Dimer Bound to DNA | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5'-D(*GP*CP*GP*TP*GP*AP*GP*CP*AP*TP*GP*CP*TP*CP*AP*C)-3', Cellular tumor antigen p53, ... | Authors: | Ho, W.C, Fitzgerald, M.X, Marmorstein, R. | Deposit date: | 2006-03-20 | Release date: | 2006-05-23 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of the p53 Core Domain Dimer Bound to DNA. J.Biol.Chem., 281, 2006
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2YAK
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![BU of 2yak by Molmil](/molmil-images/mine/2yak) | Structure of death-associated protein Kinase 1 (dapk1) in complex with a ruthenium octasporine ligand (OSV) | Descriptor: | DEATH-ASSOCIATED PROTEIN KINASE 1, RUTHENIUM OCTASPORINE 4 | Authors: | Feng, L, Geisselbrecht, Y, Blanck, S, Wilbuer, A, Atilla-Gokcumen, G.E, Filippakopoulos, P, Kraeling, K, Celik, M.A, Harms, K, Maksimoska, J, Marmorstein, R, Frenking, G, Knapp, S, Essen, L.-O, Meggers, E. | Deposit date: | 2011-02-23 | Release date: | 2011-04-27 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structurally Sophisticated Octahedral Metal Complexes as Highly Selective Protein Kinase Inhibitors. J.Am.Chem.Soc., 133, 2011
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6O07
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4PO2
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![BU of 4po2 by Molmil](/molmil-images/mine/4po2) | Crystal Structure of the Stress-Inducible Human Heat Shock Protein HSP70 Substrate-Binding Domain in Complex with Peptide Substrate | Descriptor: | HSP70 substrate peptide, Heat shock 70 kDa protein 1A/1B, PHOSPHATE ION, ... | Authors: | Zhang, P, Leu, J.I, Murphy, M.E, George, D.L, Marmorstein, R. | Deposit date: | 2014-02-24 | Release date: | 2014-08-20 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of the stress-inducible human heat shock protein 70 substrate-binding domain in complex with Peptide substrate. Plos One, 9, 2014
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4PZT
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![BU of 4pzt by Molmil](/molmil-images/mine/4pzt) | Crystal structure of p300 histone acetyltransferase domain in complex with an inhibitor, Acetonyl-Coenzyme A | Descriptor: | DIMETHYL SULFOXIDE, Histone acetyltransferase p300, [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-4-HYDROXY-3-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]METHYL (3R)-3-HYDROXY-2,2-DIMETHYL-4-OXO-4-{[3-OXO-3-({2-[(2-OXOPROPYL)THIO]ETHYL}AMINO)PROPYL]AMINO}BUTYL DIHYDROGEN DIPHOSPHATE | Authors: | Maksimoska, J, Marmorstein, R. | Deposit date: | 2014-03-31 | Release date: | 2014-06-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of the p300 Histone Acetyltransferase Bound to Acetyl-Coenzyme A and Its Analogues. Biochemistry, 53, 2014
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3LBX
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![BU of 3lbx by Molmil](/molmil-images/mine/3lbx) | Crystal Structure of the Erythrocyte Spectrin Tetramerization Domain Complex | Descriptor: | Spectrin alpha chain, erythrocyte, Spectrin beta chain | Authors: | Ipsaro, J.J, Harper, S.L, Messick, T.E, Marmorstein, R, Mondragon, A, Speicher, D.W. | Deposit date: | 2010-01-08 | Release date: | 2010-03-09 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure and functional interpretation of the erythrocyte spectrin tetramerization domain complex. Blood, 115, 2010
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8F23
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![BU of 8f23 by Molmil](/molmil-images/mine/8f23) | The crystal structure of a rationally designed zinc sensor based on maltose binding protein - Apo conformation | Descriptor: | Zinc Sensor protein | Authors: | Zhao, Z, Zhou, M, Zemerov, S.d, Marmorstein, R, Dmochowski, I.J. | Deposit date: | 2022-11-06 | Release date: | 2023-03-22 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Rational design of a genetically encoded NMR zinc sensor. Chem Sci, 14, 2023
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8ETB
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![BU of 8etb by Molmil](/molmil-images/mine/8etb) | the crystal structure of a rationally designed zinc sensor based on maltose binding protein - Zn binding conformation | Descriptor: | ACETATE ION, ZINC ION, Zinc Sensor protein | Authors: | Zhao, Z, Zhou, M, Zemerov, S.D, Marmorstein, R, Dmochowski, I.J. | Deposit date: | 2022-10-16 | Release date: | 2023-03-22 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.63 Å) | Cite: | Rational design of a genetically encoded NMR zinc sensor. Chem Sci, 14, 2023
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6UIA
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![BU of 6uia by Molmil](/molmil-images/mine/6uia) | |