5EBH
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1YFD
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![BU of 1yfd by Molmil](/molmil-images/mine/1yfd) | Crystal structure of the Y122H mutant of ribonucleotide reductase R2 protein from E. coli | Descriptor: | MERCURY (II) ION, MU-OXO-DIIRON, Ribonucleoside-diphosphate reductase 1 beta chain | Authors: | Kolberg, M, Logan, D.T, Bleifuss, G, Poetsch, S, Sjoeberg, B.M, Graeslund, A, Lubitz, W, Lassmann, G, Lendzian, F. | Deposit date: | 2004-12-31 | Release date: | 2005-02-15 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | A new tyrosyl radical on Phe208 as ligand to the diiron center in Escherichia coli ribonucleotide reductase, mutant R2-Y122H. Combined x-ray diffraction and EPR/ENDOR studies J.Biol.Chem., 280, 2005
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4X2J
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![BU of 4x2j by Molmil](/molmil-images/mine/4x2j) | Selection of fragments for kinase inhibitor design: decoration is key | Descriptor: | 4-[(3-aminophenyl)amino]pyrido[2,3-d]pyrimidin-5(8H)-one, SULFATE ION, TGF-beta receptor type-1 | Authors: | Czodrowski, P, Hoelzemann, G, Barnickel, G, Greiner, H, Musil, D. | Deposit date: | 2014-11-26 | Release date: | 2014-12-24 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Selection of fragments for kinase inhibitor design: decoration is key. J.Med.Chem., 58, 2015
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4X2G
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![BU of 4x2g by Molmil](/molmil-images/mine/4x2g) | Selection of fragments for kinase inhibitor design: decoration is key | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-[(4-aminophenyl)amino]pyrido[2,3-d]pyrimidin-5(6H)-one, SULFATE ION, ... | Authors: | Czodrowski, P, Hoelzemann, G, Barnickel, G, Greiner, H, Musil, D. | Deposit date: | 2014-11-26 | Release date: | 2015-08-12 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.51 Å) | Cite: | Selection of fragments for kinase inhibitor design: decoration is key. J.Med.Chem., 58, 2015
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4X0M
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![BU of 4x0m by Molmil](/molmil-images/mine/4x0m) | Selection of fragments for kinase inhibitor design: decoration is key | Descriptor: | 4-aminopyrido[2,3-d]pyrimidin-5(8H)-one, SULFATE ION, TGF-beta receptor type-1 | Authors: | Czodrowski, P, Hoelzemann, G, Barnickel, G, Greiner, H, Musil, D. | Deposit date: | 2014-11-21 | Release date: | 2014-12-24 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.68 Å) | Cite: | Selection of fragments for kinase inhibitor design: decoration is key. J.Med.Chem., 58, 2015
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5ANJ
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![BU of 5anj by Molmil](/molmil-images/mine/5anj) | Crystal structure of CDK2 in complex with N-(9H-purin-6-yl)thiophene- 2-carboxamide processed with the CrystalDirect automated mounting and cryo-cooling technology | Descriptor: | CYCLIN-DEPENDENT KINASE 2, N-(9H-purin-6-yl)thiophene-2-carboxamide | Authors: | Zander, U, Hoffmann, G, Mathieu, M, Marquette, J.-P, Cornaciu, I, Cipriani, F, Marquez, J.A. | Deposit date: | 2015-09-07 | Release date: | 2016-04-13 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Automated Harvesting and Processing of Protein Crystals Through Laser Photoablation. Acta Crystallogr.,Sect.D, 72, 2016
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5ANO
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![BU of 5ano by Molmil](/molmil-images/mine/5ano) | Crystal structure of CDK2 processed with the CrystalDirect automated mounting and cryo-cooling technology | Descriptor: | CYCLIN-DEPENDENT KINASE 2 | Authors: | Zander, U, Hoffmann, G, Mathieu, M, Marquette, J.-P, Cornaciu, I, Cipriani, F, Marquez, J.A. | Deposit date: | 2015-09-07 | Release date: | 2016-04-13 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Automated Harvesting and Processing of Protein Crystals Through Laser Photoablation. Acta Crystallogr.,Sect.D, 72, 2016
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3PYY
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![BU of 3pyy by Molmil](/molmil-images/mine/3pyy) | Discovery and Characterization of a Cell-Permeable, Small-molecule c-Abl Kinase Activator that Binds to the Myristoyl Binding Site | Descriptor: | (5R)-5-[3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]imidazolidine-2,4-dione, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, GLYCEROL, ... | Authors: | Yang, J, Campobasso, N, Biju, M.P, Fisher, K, Pan, X.Q, Cottom, J, Galbraith, S, Ho, T, Zhang, H, Hong, X, Ward, P, Hofmann, G, Siegfried, B. | Deposit date: | 2010-12-13 | Release date: | 2011-03-09 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Discovery and Characterization of a Cell-Permeable, Small-Molecule c-Abl Kinase Activator that Binds to the Myristoyl Binding Site. Chem.Biol., 18, 2011
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4K8A
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![BU of 4k8a by Molmil](/molmil-images/mine/4k8a) | Fragment-based discovery of Focal Adhesion Kinase Inhibitors | Descriptor: | 3-bromo-5-(2H-tetrazol-5-yl)pyridine, Focal adhesion kinase 1 | Authors: | Graedler, U, Bomke, J, Musil, D, Dresing, V, Lehmann, M, Hoelzemann, G, Esdar, C, Krier, M, Heinrich, T. | Deposit date: | 2013-04-18 | Release date: | 2013-09-11 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.91 Å) | Cite: | Fragment-based discovery of focal adhesion kinase inhibitors. Bioorg.Med.Chem.Lett., 23, 2013
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2C5U
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![BU of 2c5u by Molmil](/molmil-images/mine/2c5u) | T4 RNA Ligase (Rnl1) Crystal Structure | Descriptor: | CALCIUM ION, CHLORIDE ION, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ... | Authors: | El Omari, K, Ren, J, Bird, L.E, Bona, M.K, Klarmann, G, LeGrice, S.F.J, Stammers, D.K. | Deposit date: | 2005-11-01 | Release date: | 2005-11-04 | Last modified: | 2012-09-12 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Molecular Architecture and Ligand Recognition Determinants for T4 RNA Ligase J.Biol.Chem., 281, 2006
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1K2V
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![BU of 1k2v by Molmil](/molmil-images/mine/1k2v) | E. COLI PERIPLASMIC PROTEIN FHUD COMPLEXED WITH DESFERAL | Descriptor: | DEFEROXAMINE MESYLATE FE(III) COMPLEX, Ferrichrome-binding periplasmic protein | Authors: | Clarke, T.E, Braun, V, Winkelmann, G, Tari, L.W, Vogel, H.J. | Deposit date: | 2001-09-29 | Release date: | 2002-04-17 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | X-ray crystallographic structures of the Escherichia coli periplasmic protein FhuD bound to hydroxamate-type siderophores and the antibiotic albomycin. J.Biol.Chem., 277, 2002
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1K7S
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![BU of 1k7s by Molmil](/molmil-images/mine/1k7s) | FhuD complexed with albomycin-delta 2 | Descriptor: | DELTA-2-ALBOMYCIN A1, Ferrichrome-binding periplasmic protein | Authors: | Clarke, T.E, Braun, V, Winkelmann, G, Tari, L.W, Vogel, H.J. | Deposit date: | 2001-10-21 | Release date: | 2002-04-17 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | X-ray crystallographic structures of the Escherichia coli periplasmic protein FhuD bound to hydroxamate-type siderophores and the antibiotic albomycin. J.Biol.Chem., 277, 2002
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4UG1
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![BU of 4ug1 by Molmil](/molmil-images/mine/4ug1) | GpsB N-terminal domain | Descriptor: | CELL CYCLE PROTEIN GPSB, IMIDAZOLE, NICKEL (II) ION | Authors: | Rismondo, J, Cleverley, R.M, Lane, H.V, Grohennig, S, Steglich, A, Muller, L, Krishna Mannala, G, Hain, T, Lewis, R.J, Halbedel, S. | Deposit date: | 2015-03-20 | Release date: | 2015-11-25 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure of the Bacterial Cell Division Determinant Gpsb and its Interaction with Penicillin Binding Proteins. Mol.Microbiol., 99, 2016
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4UG3
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![BU of 4ug3 by Molmil](/molmil-images/mine/4ug3) | B. subtilis GpsB N-terminal Domain | Descriptor: | CELL CYCLE PROTEIN GPSB | Authors: | Rismondo, J, Cleverley, R.M, Lane, H.V, Grohennig, S, Steglich, A, Moller, L, Krishna Mannala, G, Hain, T, Lewis, R.J, Halbedel, S. | Deposit date: | 2015-03-21 | Release date: | 2015-11-25 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of the Bacterial Cell Division Determinant Gpsb and its Interaction with Penicillin Binding Proteins. Mol.Microbiol., 99, 2016
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1DP3
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![BU of 1dp3 by Molmil](/molmil-images/mine/1dp3) | SOLUTION STRUCTURE OF THE DNA BINDING DOMAIN OF THE TRAM PROTEIN | Descriptor: | TRAM PROTEIN | Authors: | Stockner, T, Plugariu, C, Koraimann, G, Hoegenauer, G, Bermel, W, Prytulla, S, Sterk, H. | Deposit date: | 1999-12-23 | Release date: | 2001-04-04 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure of the DNA-binding domain of TraM. Biochemistry, 40, 2001
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3M1S
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![BU of 3m1s by Molmil](/molmil-images/mine/3m1s) | Structure of Ruthenium Half-Sandwich Complex Bound to Glycogen Synthase Kinase 3 | Descriptor: | Glycogen synthase kinase-3 beta, Ruthenium pyridocarbazole | Authors: | Atilla-Gokcumen, G.E, Di Costanzo, L, Zimmermann, G, Meggers, E. | Deposit date: | 2010-03-05 | Release date: | 2010-12-22 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.134 Å) | Cite: | Structure of anticancer ruthenium half-sandwich complex bound to glycogen synthase kinase 3beta J.Biol.Inorg.Chem., 16, 2011
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7ZKE
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![BU of 7zke by Molmil](/molmil-images/mine/7zke) | Mot1:TBP:DNA - pre-hydrolysis state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (36-MER), ... | Authors: | Woike, S, Eustermann, S, Jung, J, Wenzl, S.J, Hagemann, G, Bartho, J.D, Lammens, K, Butryn, A, Herzog, F, Hopfner, K.-P. | Deposit date: | 2022-04-12 | Release date: | 2023-04-26 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural basis for TBP displacement from TATA box DNA by the Swi2/Snf2 ATPase Mot1. Nat.Struct.Mol.Biol., 30, 2023
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5AN5
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![BU of 5an5 by Molmil](/molmil-images/mine/5an5) | B. subtilis GpsB C-terminal Domain | Descriptor: | CELL CYCLE PROTEIN GPSB, GLYCEROL | Authors: | Rismondo, J, Cleverley, R.M, Lane, H.V, Grohennig, S, Steglich, A, Moller, L, Krishna Mannala, G, Hain, T, Lewis, R.J, Halbedel, S. | Deposit date: | 2015-09-04 | Release date: | 2015-11-25 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Structure of the Bacterial Cell Division Determinant Gpsb and its Interaction with Penicillin Binding Proteins. Mol.Microbiol., 99, 2016
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2CC3
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![BU of 2cc3 by Molmil](/molmil-images/mine/2cc3) | Structure of Agrobacterium tumefaciens VirB8 protein | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, PROTEIN VIRB8 | Authors: | Bailey, S, Ward, D, Middleton, R, Grossmann, G, Zambryski, P.C. | Deposit date: | 2006-01-11 | Release date: | 2006-01-30 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Agrobacterium Tumefaciens Virb8 Structure Reveals Potential Protein-Protein Interactions Sites. Proc.Natl.Acad.Sci.USA, 103, 2006
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1R9L
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![BU of 1r9l by Molmil](/molmil-images/mine/1r9l) | structure analysis of ProX in complex with glycine betaine | Descriptor: | Glycine betaine-binding periplasmic protein, TRIMETHYL GLYCINE, UNKNOWN ATOM OR ION | Authors: | Schiefner, A, Breed, J, Bosser, L, Kneip, S, Gade, J, Holtmann, G, Diederichs, K, Welte, W, Bremer, E. | Deposit date: | 2003-10-30 | Release date: | 2004-02-24 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Cation-pi Interactions as Determinants for Binding of the Compatible Solutes Glycine Betaine and Proline Betaine by the Periplasmic Ligand-binding Protein ProX from Escherichia coli J.BIOL.CHEM., 279, 2004
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1R9Q
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![BU of 1r9q by Molmil](/molmil-images/mine/1r9q) | structure analysis of ProX in complex with proline betaine | Descriptor: | 1,1-DIMETHYL-PROLINIUM, Glycine betaine-binding periplasmic protein, UNKNOWN ATOM OR ION | Authors: | Schiefner, A, Breed, J, Bosser, L, Kneip, S, Gade, J, Holtmann, G, Diederichs, K, Welte, W, Bremer, E. | Deposit date: | 2003-10-30 | Release date: | 2004-02-24 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Cation-pi Interactions as Determinants for Binding of the Compatible Solutes Glycine Betaine and Proline Betaine by the Periplasmic Ligand-binding Protein ProX from Escherichia coli J.BIOL.CHEM., 279, 2004
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1SW5
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![BU of 1sw5 by Molmil](/molmil-images/mine/1sw5) | Crystal structure of ProX from Archeoglobus fulgidus in the ligand free form | Descriptor: | CHLORIDE ION, MAGNESIUM ION, osmoprotection protein (proX) | Authors: | Schiefner, A, Holtmann, G, Diederichs, K, Welte, W, Bremer, E. | Deposit date: | 2004-03-30 | Release date: | 2004-09-14 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural basis for the binding of compatible solutes by ProX from the hyperthermophilic archaeon Archaeoglobus fulgidus. J.Biol.Chem., 279, 2004
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1SW1
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![BU of 1sw1 by Molmil](/molmil-images/mine/1sw1) | Crystal structure of ProX from Archeoglobus fulgidus in complex with proline betaine | Descriptor: | 1,1-DIMETHYL-PROLINIUM, ZINC ION, osmoprotection protein (proX) | Authors: | Schiefner, A, Holtmann, G, Diederichs, K, Welte, W, Bremer, E. | Deposit date: | 2004-03-30 | Release date: | 2004-09-14 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis for the binding of compatible solutes by ProX from the hyperthermophilic archaeon Archaeoglobus fulgidus. J.Biol.Chem., 279, 2004
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1SW4
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![BU of 1sw4 by Molmil](/molmil-images/mine/1sw4) | Crystal structure of ProX from Archeoglobus fulgidus in complex with trimethyl ammonium | Descriptor: | CHLORIDE ION, TETRAMETHYLAMMONIUM ION, ZINC ION, ... | Authors: | Schiefner, A, Holtmann, G, Diederichs, K, Welte, W, Bremer, E. | Deposit date: | 2004-03-30 | Release date: | 2004-09-14 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis for the binding of compatible solutes by ProX from the hyperthermophilic archaeon Archaeoglobus fulgidus. J.Biol.Chem., 279, 2004
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1ESZ
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![BU of 1esz by Molmil](/molmil-images/mine/1esz) | STRUCTURE OF THE PERIPLASMIC FERRIC SIDEROPHORE BINDING PROTEIN FHUD COMPLEXED WITH COPROGEN | Descriptor: | COPROGEN, FERRICHROME-BINDING PERIPLASMIC PROTEIN | Authors: | Clarke, T.E, Braun, V, Winkelmann, G, Tari, L.W, Vogel, H.J. | Deposit date: | 2000-04-11 | Release date: | 2002-04-17 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | X-ray crystallographic structures of the Escherichia coli periplasmic protein FhuD bound to hydroxamate-type siderophores and the antibiotic albomycin. J.Biol.Chem., 277, 2002
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