4K8A
Fragment-based discovery of Focal Adhesion Kinase Inhibitors
Summary for 4K8A
| Entry DOI | 10.2210/pdb4k8a/pdb |
| Related | 3PXK 4K9Y 4KAB 4KAO |
| Descriptor | Focal adhesion kinase 1, 3-bromo-5-(2H-tetrazol-5-yl)pyridine (3 entities in total) |
| Functional Keywords | tyrosine protein kinase, transferase, atp binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Cell junction, focal adhesion: Q05397 |
| Total number of polymer chains | 2 |
| Total formula weight | 64367.92 |
| Authors | Graedler, U.,Bomke, J.,Musil, D.,Dresing, V.,Lehmann, M.,Hoelzemann, G.,Esdar, C.,Krier, M.,Heinrich, T. (deposition date: 2013-04-18, release date: 2013-09-11, Last modification date: 2023-12-27) |
| Primary citation | Gradler, U.,Bomke, J.,Musil, D.,Dresing, V.,Lehmann, M.,Holzemann, G.,Greiner, H.,Esdar, C.,Krier, M.,Heinrich, T. Fragment-based discovery of focal adhesion kinase inhibitors. Bioorg.Med.Chem.Lett., 23:5401-5409, 2013 Cited by PubMed: 23973211DOI: 10.1016/j.bmcl.2013.07.050 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.91 Å) |
Structure validation
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