4K8A
Fragment-based discovery of Focal Adhesion Kinase Inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Focal adhesion kinase 1 | polymer | 279 | 31957.9 | 2 | UniProt (Q05397) Pfam (PF07714) | Homo sapiens (human) | FADK 1, Focal adhesion kinase-related nonkinase, FRNK, Protein phosphatase 1 regulatory subunit 71, PPP1R71, Protein-tyrosine kinase 2, p125FAK, pp125FAK |
| 2 | C, D (A, B) | 3-bromo-5-(2H-tetrazol-5-yl)pyridine | non-polymer | 226.0 | 2 | Chemie (K8A) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 21 | Chemie (HOH) |
Sequence modifications
A, B: 410 - 686 (UniProt: Q05397)
| PDB | External Database | Details |
|---|---|---|
| Gly 408 | - | expression tag |
| Ser 409 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 63915.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 452.1 | |
| All* | Total formula weight | 64367.9 |
