4K9Y

FOCAL ADHESION KINASE Catalytic domain in complex with 1-[4-(6-Amino-purin-9-yl)-phenyl]-3-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-urea

Summary for 4K9Y

Entry DOI	10.2210/pdb4k9y/pdb
Related	4GU6 4GU9 4K8A 4KAB 4KAO
Descriptor	Focal adhesion kinase 1, 1-[4-(6-amino-9H-purin-9-yl)phenyl]-3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]urea (3 entities in total)
Functional Keywords	tyrosine protein kinase, transferase, atp binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cell junction, focal adhesion: Q05397
Total number of polymer chains	1
Total formula weight	32439.48
Authors	Musil, D.,Graedler, U.,Lehmann, M.,Heinrich, T.,Dresing, V. (deposition date: 2013-04-21, release date: 2013-09-11, Last modification date: 2013-10-09)
Primary citation	Gradler, U.,Bomke, J.,Musil, D.,Dresing, V.,Lehmann, M.,Holzemann, G.,Greiner, H.,Esdar, C.,Krier, M.,Heinrich, T. Fragment-based discovery of focal adhesion kinase inhibitors. Bioorg.Med.Chem.Lett., 23:5401-5409, 2013 Cited by PubMed: 23973211 DOI: 10.1016/j.bmcl.2013.07.050 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation