4KAO
FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-(4-pyridin-3- yl-phenyl)-urea
Summary for 4KAO
Entry DOI | 10.2210/pdb4kao/pdb |
Related | 4GU6 4GU9 4K8A 4K9Y 4KAB |
Descriptor | Focal adhesion kinase 1, 1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-[4-(pyridin-3-yl)phenyl]urea, SULFATE ION, ... (4 entities in total) |
Functional Keywords | tyrosine protein kinase, transferase, atp binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cell junction, focal adhesion: Q05397 |
Total number of polymer chains | 2 |
Total formula weight | 65555.56 |
Authors | Musil, D.,Graedler, U.,Heinrich, T.,Lehmann, M.,Dresing, V. (deposition date: 2013-04-22, release date: 2013-09-11, Last modification date: 2013-10-09) |
Primary citation | Gradler, U.,Bomke, J.,Musil, D.,Dresing, V.,Lehmann, M.,Holzemann, G.,Greiner, H.,Esdar, C.,Krier, M.,Heinrich, T. Fragment-based discovery of focal adhesion kinase inhibitors. Bioorg.Med.Chem.Lett., 23:5401-5409, 2013 Cited by PubMed: 23973211DOI: 10.1016/j.bmcl.2013.07.050 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.39 Å) |
Structure validation
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