4KAO
FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-(4-pyridin-3- yl-phenyl)-urea
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Focal adhesion kinase 1 | polymer | 282 | 32304.2 | 2 | UniProt (Q05397) Pfam (PF07714) | Homo sapiens (human) | FADK 1, Focal adhesion kinase-related nonkinase, FRNK, Protein phosphatase 1 regulatory subunit 71, PPP1R71, Protein-tyrosine kinase 2, p125FAK, pp125FAK |
| 2 | C, E (A, B) | 1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-[4-(pyridin-3-yl)phenyl]urea | non-polymer | 425.5 | 2 | Chemie (KAO) | |||
| 3 | D (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 62 | Chemie (HOH) |
Sequence modifications
A, B: 410 - 689 (UniProt: Q05397)
| PDB | External Database | Details |
|---|---|---|
| Gly 408 | - | expression tag |
| Ser 409 | - | expression tag |
| Gly 410 | Pro 410 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 64608.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 947.1 | |
| All* | Total formula weight | 65555.6 |
