4X0M

Selection of fragments for kinase inhibitor design: decoration is key

Summary for 4X0M

• Entry DOI: 10.2210/pdb4x0m/pdb
• Related: 1vjy
• Descriptor: TGF-beta receptor type-1, 4-aminopyrido[2,3-d]pyrimidin-5(8H)-one, SULFATE ION, ... (4 entities in total)
• Functional Keywords: transferase, protein kinase, inhibitor complex
• Biological source: Homo sapiens (Human)
• Cellular location: Cell membrane; Single-pass type I membrane protein: P36897
• Total number of polymer chains: 1
• Total formula weight: 35140.36

Authors

Czodrowski, P.,Hoelzemann, G.,Barnickel, G.,Greiner, H.,Musil, D. (deposition date: 2014-11-21, release date: 2014-12-24, Last modification date: 2024-01-10)

• Primary citation: Czodrowski, P.,Holzemann, G.,Barnickel, G.,Greiner, H.,Musil, D.; Selection of fragments for kinase inhibitor design: decoration is key.; J.Med.Chem., 58:457-465, 2015; PubMed: 25437144; DOI: 10.1021/jm501597j

Experimental method

X-RAY DIFFRACTION (1.68 Å)