2XHC
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2MPN
| 3D NMR structure of the transmembrane domain of the full-length inner membrane protein YgaP from Escherichia coli | 分子名称: | Inner membrane protein YgaP | 著者 | Eichmann, C, Tzitzilonis, C, Bordignon, E, Maslennikov, I, Choe, S, Riek, R. | 登録日 | 2014-05-29 | 公開日 | 2014-06-25 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution NMR Structure and Functional Analysis of the Integral Membrane Protein YgaP from Escherichia coli. J.Biol.Chem., 289, 2014
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5BTV
| Crystal structure of human 14-3-3 sigma in complex with a Tau-protein peptide surrounding pS324 | 分子名称: | 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... | 著者 | Ottmann, C, Schumacher, B, Bartel, M. | 登録日 | 2015-06-03 | 公開日 | 2016-07-20 | 最終更新日 | 2019-03-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau. Faseb J., 29, 2015
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2H5C
| 0.82A resolution crystal structure of alpha-lytic protease at pH 5 | 分子名称: | ALPHA-LYTIC PROTEASE, GLYCEROL, SULFATE ION | 著者 | Fuhrmann, C.N, Daugherty, M.D, Agard, D.A. | 登録日 | 2006-05-25 | 公開日 | 2006-09-26 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (0.82 Å) | 主引用文献 | Subangstrom crystallography reveals that short ionic hydrogen bonds, and not a His-Asp low-barrier hydrogen bond, stabilize the transition state in serine protease catalysis J.Am.Chem.Soc., 128, 2006
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6QZS
| 14-3-3 sigma in complex with FOXO1 pS256 peptide | 分子名称: | 14-3-3 protein sigma, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FOXO1 pS256 site, ... | 著者 | Ottmann, C, Wolter, M, Lau, R.A. | 登録日 | 2019-03-12 | 公開日 | 2019-07-31 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | AMPK and AKT protein kinases hierarchically phosphorylate the N-terminus of the FOXO1 transcription factor, modulating interactions with 14-3-3 proteins. J.Biol.Chem., 294, 2019
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1WWA
| NGF BINDING DOMAIN OF HUMAN TRKA RECEPTOR | 分子名称: | PROTEIN (NERVE GROWTH FACTOR RECEPTOR TRKA) | 著者 | Wiesmann, C, Ultsch, M.H, Bass, S.H, De Vos, A.M. | 登録日 | 1999-04-29 | 公開日 | 1999-07-07 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC. J.Mol.Biol., 290, 1999
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1NNX
| Structure of the hypothetical protein ygiW from E. coli. | 分子名称: | Protein ygiW, SULFATE ION | 著者 | Lehmann, C, Galkin, A, Pullalarevu, S, Sarikaya, E, Krajewski, W, Lim, K, Howard, A, Herzberg, O, Structure 2 Function Project (S2F) | 登録日 | 2003-01-14 | 公開日 | 2004-03-09 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Structure of the hypothetical protein ygiW from E. coli. To be Published
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3PBG
| 6-PHOSPHO-BETA-GALACTOSIDASE FORM-C | 分子名称: | 6-PHOSPHO-BETA-D-GALACTOSIDASE, SULFATE ION | 著者 | Wiesmann, C, Schulz, G.E. | 登録日 | 1997-02-21 | 公開日 | 1997-07-23 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Crystal structures and mechanism of 6-phospho-beta-galactosidase from Lactococcus lactis. J.Mol.Biol., 269, 1997
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2ICE
| CRIg bound to C3c | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Complement C3 alpha chain, ... | 著者 | Wiesmann, C. | 登録日 | 2006-09-12 | 公開日 | 2006-11-07 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structure of C3b in complex with CRIg gives insights into regulation of complement activation. Nature, 444, 2006
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2ICF
| CRIg bound to C3b | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Complement C3 alpha chain, ... | 著者 | Wiesmann, C. | 登録日 | 2006-09-12 | 公開日 | 2006-11-07 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (4.1 Å) | 主引用文献 | Structure of C3b in complex with CRIg gives insights into regulation of complement activation. Nature, 444, 2006
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2XHA
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3FC5
| G586S mutant nNOSoxy | 分子名称: | 5,6,7,8-TETRAHYDROBIOPTERIN, ARGININE, Nitric oxide synthase, ... | 著者 | Bruckmann, C, Mowat, C.G. | 登録日 | 2008-11-21 | 公開日 | 2009-11-03 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | Oxygen Activation in Neuronal NO Synthase: Stabilisation of a Novel Intermediate in the G586S Mutant To be Published
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3DBS
| Structure of PI3K gamma in complex with GDC0941 | 分子名称: | 2-(1H-indazol-4-yl)-6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-4-morpholin-4-yl-thieno[3,2-d]pyrimidine, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 著者 | Wiesmann, C, Ultsch, M. | 登録日 | 2008-06-02 | 公開日 | 2008-06-17 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer J.Med.Chem., 51, 2008
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2HU6
| Crystal structure of human MMP-12 in complex with acetohydroxamic acid and a bicyclic inhibitor | 分子名称: | (1S,5S,7R)-N~7~-(BIPHENYL-4-YLMETHYL)-N~3~-HYDROXY-6,8-DIOXA-3-AZABICYCLO[3.2.1]OCTANE-3,7-DICARBOXAMIDE, ACETOHYDROXAMIC ACID, CALCIUM ION, ... | 著者 | Mannino, C, Nievo, M, Machetti, F, Papakyriakou, A, Calderone, V, Fragai, M, Guarna, A. | 登録日 | 2006-07-26 | 公開日 | 2006-12-19 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.32 Å) | 主引用文献 | Synthesis of bicyclic molecular scaffolds (BTAa): an investigation towards new selective MMP-12 inhibitors. Bioorg.Med.Chem., 14, 2006
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2LHN
| RNA-binding zinc finger protein | 分子名称: | Nuclear polyadenylated RNA-binding protein NAB2, ZINC ION | 著者 | Brockmann, C, Neuhaus, D, Stewart, M. | 登録日 | 2011-08-12 | 公開日 | 2012-06-27 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural Basis for Polyadenosine-RNA Binding by Nab2 Zn Fingers and Its Function in mRNA Nuclear Export. Structure, 20, 2012
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2PBG
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2IFC
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2XYI
| Crystal Structure of Nurf55 in complex with a H4 peptide | 分子名称: | DI(HYDROXYETHYL)ETHER, HISTONE H4, PROBABLE HISTONE-BINDING PROTEIN CAF1, ... | 著者 | Stirnimann, C.U, Nowak, A.J, Mueller, C.W. | 登録日 | 2010-11-17 | 公開日 | 2011-05-04 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Chromatin-Modifying Complex Component Nurf55/P55 Associates with Histones H3, H4 and Polycomb Repressive Complex 2 Subunit Su(Z)12 Through Partially Overlapping Binding Sites. J.Biol.Chem., 286, 2011
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3E6Y
| Structure of 14-3-3 in complex with the differentiation-inducing agent Cotylenin A | 分子名称: | 14-3-3-like protein C, CHLORIDE ION, Cotylenin A, ... | 著者 | Ottmann, C, Weyand, M, Wittinghofer, A, Oecking, C. | 登録日 | 2008-08-17 | 公開日 | 2009-03-10 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | A structural rationale for selective stabilization of anti-tumor interactions of 14-3-3 proteins by cotylenin A J.Mol.Biol., 386, 2009
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2H5D
| 0.9A resolution crystal structure of alpha-lytic protease complexed with a transition state analogue, MeOSuc-Ala-Ala-Pro-Val boronic acid | 分子名称: | ALPHA-LYTIC PROTEASE, GLYCEROL, MEOSUC-ALA-ALA-PRO-ALA BORONIC ACID INHIBITOR, ... | 著者 | Fuhrmann, C.N, Agard, D.A. | 登録日 | 2006-05-25 | 公開日 | 2006-09-26 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (0.9 Å) | 主引用文献 | Subangstrom crystallography reveals that short ionic hydrogen bonds, and not a His-Asp low-barrier hydrogen bond, stabilize the transition state in serine protease catalysis J.Am.Chem.Soc., 128, 2006
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2FJG
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1VPP
| COMPLEX BETWEEN VEGF AND A RECEPTOR BLOCKING PEPTIDE | 分子名称: | PROTEIN (PEPTIDE V108), PROTEIN (VASCULAR ENDOTHELIAL GROWTH FACTOR) | 著者 | Wiesmann, C, Christinger, H.W, Cochran, A.G, Cunningham, B.C, Fairbrother, W.J, Keenan, C.J, Meng, G, de Vos, A.M. | 登録日 | 1998-10-09 | 公開日 | 1999-02-23 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structure of the complex between VEGF and a receptor-blocking peptide. Biochemistry, 37, 1998
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1Z5Y
| Crystal Structure Of The Disulfide-Linked Complex Between The N-Terminal Domain Of The Electron Transfer Catalyst DsbD and The Cytochrome c Biogenesis Protein CcmG | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Thiol:disulfide interchange protein dsbD, ... | 著者 | Stirnimann, C.U, Rozhkova, A, Grauschopf, U, Gruetter, M.G, Glockshuber, R, Capitani, G. | 登録日 | 2005-03-21 | 公開日 | 2005-07-19 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Structural Basis and Kinetics of DsbD-Dependent Cytochrome c Maturation STRUCTURE, 13, 2005
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2FJF
| Structure of the G6 Fab, a phage derived VEGF binding Fab | 分子名称: | Heavy Chain of a VEGF binding Antibody, Light Chain of a VEGF binding Antibody | 著者 | Wiesmann, C. | 登録日 | 2006-01-02 | 公開日 | 2006-02-07 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Structure-function studies of two synthetic anti-vascular endothelial growth factor Fabs and comparison with the Avastin Fab. J.Biol.Chem., 281, 2006
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3O8I
| Structure of 14-3-3 isoform sigma in complex with a C-Raf1 peptide and a stabilizing small molecule fragment | 分子名称: | 14-3-3 binding site peptide of RAF proto-oncogene serine/threonine-protein kinase, 14-3-3 protein sigma, 6,6-dihydroxy-1-methoxyhexan-2-one | 著者 | Ottmann, C, Rose, R, Kaiser, M, Kuhenne, P. | 登録日 | 2010-08-03 | 公開日 | 2010-09-29 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Impaired Binding of 14-3-3 to C-RAF in Noonan Syndrome Suggests New Approaches in Diseases with Increased Ras Signaling Mol.Cell.Biol., 30, 2010
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