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PDB: 1076 件

2XHC
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Crystal Structure of Thermotoga maritima N-utilization Substance G (NusG)
分子名称: TRANSCRIPTION ANTITERMINATION PROTEIN NUSG
著者Stegmann, C.M, Wahl, M.C.
登録日2010-06-14
公開日2011-06-29
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献An Autoinhibited State in the Structure of Thermotoga Maritima Nusg.
Structure, 21, 2013
2MPN
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3D NMR structure of the transmembrane domain of the full-length inner membrane protein YgaP from Escherichia coli
分子名称: Inner membrane protein YgaP
著者Eichmann, C, Tzitzilonis, C, Bordignon, E, Maslennikov, I, Choe, S, Riek, R.
登録日2014-05-29
公開日2014-06-25
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Solution NMR Structure and Functional Analysis of the Integral Membrane Protein YgaP from Escherichia coli.
J.Biol.Chem., 289, 2014
5BTV
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Crystal structure of human 14-3-3 sigma in complex with a Tau-protein peptide surrounding pS324
分子名称: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ...
著者Ottmann, C, Schumacher, B, Bartel, M.
登録日2015-06-03
公開日2016-07-20
最終更新日2019-03-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau.
Faseb J., 29, 2015
2H5C
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0.82A resolution crystal structure of alpha-lytic protease at pH 5
分子名称: ALPHA-LYTIC PROTEASE, GLYCEROL, SULFATE ION
著者Fuhrmann, C.N, Daugherty, M.D, Agard, D.A.
登録日2006-05-25
公開日2006-09-26
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (0.82 Å)
主引用文献Subangstrom crystallography reveals that short ionic hydrogen bonds, and not a His-Asp low-barrier hydrogen bond, stabilize the transition state in serine protease catalysis
J.Am.Chem.Soc., 128, 2006
6QZS
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14-3-3 sigma in complex with FOXO1 pS256 peptide
分子名称: 14-3-3 protein sigma, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, FOXO1 pS256 site, ...
著者Ottmann, C, Wolter, M, Lau, R.A.
登録日2019-03-12
公開日2019-07-31
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献AMPK and AKT protein kinases hierarchically phosphorylate the N-terminus of the FOXO1 transcription factor, modulating interactions with 14-3-3 proteins.
J.Biol.Chem., 294, 2019
1WWA
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NGF BINDING DOMAIN OF HUMAN TRKA RECEPTOR
分子名称: PROTEIN (NERVE GROWTH FACTOR RECEPTOR TRKA)
著者Wiesmann, C, Ultsch, M.H, Bass, S.H, De Vos, A.M.
登録日1999-04-29
公開日1999-07-07
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC.
J.Mol.Biol., 290, 1999
1NNX
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Structure of the hypothetical protein ygiW from E. coli.
分子名称: Protein ygiW, SULFATE ION
著者Lehmann, C, Galkin, A, Pullalarevu, S, Sarikaya, E, Krajewski, W, Lim, K, Howard, A, Herzberg, O, Structure 2 Function Project (S2F)
登録日2003-01-14
公開日2004-03-09
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Structure of the hypothetical protein ygiW from E. coli.
To be Published
3PBG
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6-PHOSPHO-BETA-GALACTOSIDASE FORM-C
分子名称: 6-PHOSPHO-BETA-D-GALACTOSIDASE, SULFATE ION
著者Wiesmann, C, Schulz, G.E.
登録日1997-02-21
公開日1997-07-23
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structures and mechanism of 6-phospho-beta-galactosidase from Lactococcus lactis.
J.Mol.Biol., 269, 1997
2ICE
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BU of 2ice by Molmil
CRIg bound to C3c
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Complement C3 alpha chain, ...
著者Wiesmann, C.
登録日2006-09-12
公開日2006-11-07
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structure of C3b in complex with CRIg gives insights into regulation of complement activation.
Nature, 444, 2006
2ICF
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CRIg bound to C3b
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Complement C3 alpha chain, ...
著者Wiesmann, C.
登録日2006-09-12
公開日2006-11-07
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (4.1 Å)
主引用文献Structure of C3b in complex with CRIg gives insights into regulation of complement activation.
Nature, 444, 2006
2XHA
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Crystal Structure of Domain 2 of Thermotoga maritima N-utilization Substance G (NusG)
分子名称: ACETATE ION, TRANSCRIPTION ANTITERMINATION PROTEIN NUSG
著者Stegmann, C.M, Mandal, A, Wahl, M.C.
登録日2010-06-11
公開日2011-06-29
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.906 Å)
主引用文献An Autoinhibited State in the Structure of Thermotoga Maritima Nusg.
Structure, 21, 2013
3FC5
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G586S mutant nNOSoxy
分子名称: 5,6,7,8-TETRAHYDROBIOPTERIN, ARGININE, Nitric oxide synthase, ...
著者Bruckmann, C, Mowat, C.G.
登録日2008-11-21
公開日2009-11-03
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.59 Å)
主引用文献Oxygen Activation in Neuronal NO Synthase: Stabilisation of a Novel Intermediate in the G586S Mutant
To be Published
3DBS
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BU of 3dbs by Molmil
Structure of PI3K gamma in complex with GDC0941
分子名称: 2-(1H-indazol-4-yl)-6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-4-morpholin-4-yl-thieno[3,2-d]pyrimidine, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
著者Wiesmann, C, Ultsch, M.
登録日2008-06-02
公開日2008-06-17
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer
J.Med.Chem., 51, 2008
2HU6
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Crystal structure of human MMP-12 in complex with acetohydroxamic acid and a bicyclic inhibitor
分子名称: (1S,5S,7R)-N~7~-(BIPHENYL-4-YLMETHYL)-N~3~-HYDROXY-6,8-DIOXA-3-AZABICYCLO[3.2.1]OCTANE-3,7-DICARBOXAMIDE, ACETOHYDROXAMIC ACID, CALCIUM ION, ...
著者Mannino, C, Nievo, M, Machetti, F, Papakyriakou, A, Calderone, V, Fragai, M, Guarna, A.
登録日2006-07-26
公開日2006-12-19
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.32 Å)
主引用文献Synthesis of bicyclic molecular scaffolds (BTAa): an investigation towards new selective MMP-12 inhibitors.
Bioorg.Med.Chem., 14, 2006
2LHN
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BU of 2lhn by Molmil
RNA-binding zinc finger protein
分子名称: Nuclear polyadenylated RNA-binding protein NAB2, ZINC ION
著者Brockmann, C, Neuhaus, D, Stewart, M.
登録日2011-08-12
公開日2012-06-27
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Structural Basis for Polyadenosine-RNA Binding by Nab2 Zn Fingers and Its Function in mRNA Nuclear Export.
Structure, 20, 2012
2PBG
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6-PHOSPHO-BETA-D-GALACTOSIDASE FORM-B
分子名称: 6-PHOSPHO-BETA-D-GALACTOSIDASE, SULFATE ION
著者Wiesmann, C, Schulz, G.E.
登録日1997-02-21
公開日1997-07-23
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structures and mechanism of 6-phospho-beta-galactosidase from Lactococcus lactis.
J.Mol.Biol., 269, 1997
2IFC
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BU of 2ifc by Molmil
The Structure of the Binary Complex of Oxalateacetate with Citrate Synthase from the Thermophilic Archaeon Thermolasma acidophilum
分子名称: Citrate Synthase, OXALOACETATE ION
著者Lehmann, C.
登録日2006-09-20
公開日2007-10-02
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献To be anounced
To be Published
2XYI
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BU of 2xyi by Molmil
Crystal Structure of Nurf55 in complex with a H4 peptide
分子名称: DI(HYDROXYETHYL)ETHER, HISTONE H4, PROBABLE HISTONE-BINDING PROTEIN CAF1, ...
著者Stirnimann, C.U, Nowak, A.J, Mueller, C.W.
登録日2010-11-17
公開日2011-05-04
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Chromatin-Modifying Complex Component Nurf55/P55 Associates with Histones H3, H4 and Polycomb Repressive Complex 2 Subunit Su(Z)12 Through Partially Overlapping Binding Sites.
J.Biol.Chem., 286, 2011
3E6Y
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Structure of 14-3-3 in complex with the differentiation-inducing agent Cotylenin A
分子名称: 14-3-3-like protein C, CHLORIDE ION, Cotylenin A, ...
著者Ottmann, C, Weyand, M, Wittinghofer, A, Oecking, C.
登録日2008-08-17
公開日2009-03-10
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献A structural rationale for selective stabilization of anti-tumor interactions of 14-3-3 proteins by cotylenin A
J.Mol.Biol., 386, 2009
2H5D
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0.9A resolution crystal structure of alpha-lytic protease complexed with a transition state analogue, MeOSuc-Ala-Ala-Pro-Val boronic acid
分子名称: ALPHA-LYTIC PROTEASE, GLYCEROL, MEOSUC-ALA-ALA-PRO-ALA BORONIC ACID INHIBITOR, ...
著者Fuhrmann, C.N, Agard, D.A.
登録日2006-05-25
公開日2006-09-26
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (0.9 Å)
主引用文献Subangstrom crystallography reveals that short ionic hydrogen bonds, and not a His-Asp low-barrier hydrogen bond, stabilize the transition state in serine protease catalysis
J.Am.Chem.Soc., 128, 2006
2FJG
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Structure of the G6 Fab, a phage derived Fab fragment, in complex with VEGF
分子名称: Fab heavy chain, Fab light chain, SULFATE ION, ...
著者Wiesmann, C.
登録日2006-01-02
公開日2006-02-07
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure-function studies of two synthetic anti-vascular endothelial growth factor Fabs and comparison with the Avastin Fab.
J.Biol.Chem., 281, 2006
1VPP
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COMPLEX BETWEEN VEGF AND A RECEPTOR BLOCKING PEPTIDE
分子名称: PROTEIN (PEPTIDE V108), PROTEIN (VASCULAR ENDOTHELIAL GROWTH FACTOR)
著者Wiesmann, C, Christinger, H.W, Cochran, A.G, Cunningham, B.C, Fairbrother, W.J, Keenan, C.J, Meng, G, de Vos, A.M.
登録日1998-10-09
公開日1999-02-23
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of the complex between VEGF and a receptor-blocking peptide.
Biochemistry, 37, 1998
1Z5Y
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BU of 1z5y by Molmil
Crystal Structure Of The Disulfide-Linked Complex Between The N-Terminal Domain Of The Electron Transfer Catalyst DsbD and The Cytochrome c Biogenesis Protein CcmG
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Thiol:disulfide interchange protein dsbD, ...
著者Stirnimann, C.U, Rozhkova, A, Grauschopf, U, Gruetter, M.G, Glockshuber, R, Capitani, G.
登録日2005-03-21
公開日2005-07-19
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Structural Basis and Kinetics of DsbD-Dependent Cytochrome c Maturation
STRUCTURE, 13, 2005
2FJF
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Structure of the G6 Fab, a phage derived VEGF binding Fab
分子名称: Heavy Chain of a VEGF binding Antibody, Light Chain of a VEGF binding Antibody
著者Wiesmann, C.
登録日2006-01-02
公開日2006-02-07
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Structure-function studies of two synthetic anti-vascular endothelial growth factor Fabs and comparison with the Avastin Fab.
J.Biol.Chem., 281, 2006
3O8I
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Structure of 14-3-3 isoform sigma in complex with a C-Raf1 peptide and a stabilizing small molecule fragment
分子名称: 14-3-3 binding site peptide of RAF proto-oncogene serine/threonine-protein kinase, 14-3-3 protein sigma, 6,6-dihydroxy-1-methoxyhexan-2-one
著者Ottmann, C, Rose, R, Kaiser, M, Kuhenne, P.
登録日2010-08-03
公開日2010-09-29
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Impaired Binding of 14-3-3 to C-RAF in Noonan Syndrome Suggests New Approaches in Diseases with Increased Ras Signaling
Mol.Cell.Biol., 30, 2010

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