6P0Z
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![BU of 6p0z by Molmil](/molmil-images/mine/6p0z) | Crystal structure of N-acetylated KRAS (2-169) bound to GDP and Mg | Descriptor: | ACETYL GROUP, DI(HYDROXYETHYL)ETHER, GTPase KRas, ... | Authors: | Dharmaiah, S, Tran, T.H, Yan, W, Simanshu, D.K. | Deposit date: | 2019-05-17 | Release date: | 2019-07-31 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.011 Å) | Cite: | Structures of N-terminally processed KRAS provide insight into the role of N-acetylation. Sci Rep, 9, 2019
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1ZUQ
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![BU of 1zuq by Molmil](/molmil-images/mine/1zuq) | Contribution to Structure and Catalysis of Tyrosine 34 in Human Manganese Superoxide Dismutase | Descriptor: | MANGANESE (II) ION, Superoxide dismutase | Authors: | Hearn, A.S, Perry, J.J, Cabelii, D.E, Tainer, J.A, Nick, H.S, Silverman, D.S. | Deposit date: | 2005-05-31 | Release date: | 2006-05-02 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Contribution of human manganese superoxide dismutase tyrosine 34 to structure and catalysis. Biochemistry, 48, 2009
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1ZSP
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![BU of 1zsp by Molmil](/molmil-images/mine/1zsp) | Contribution to Structure and Catalysis of Tyrosine 34 in Human Manganese Superoxide Dismutase | Descriptor: | MANGANESE (II) ION, Superoxide dismutase [Mn], mitochondrial | Authors: | Hearn, A.S, Perry, J.J, Cabelli, D.E, Tainer, J.A, Nick, H.S, Silverman, D.S. | Deposit date: | 2005-05-24 | Release date: | 2006-05-02 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Contribution of human manganese superoxide dismutase tyrosine 34 to structure and catalysis. Biochemistry, 48, 2009
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2YIS
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![BU of 2yis by Molmil](/molmil-images/mine/2yis) | triazolopyridine inhibitors of p38 kinase. | Descriptor: | 1-[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]-3-{2-[(3-{2-[(2-hydroxyethyl)sulfanyl]phenyl}[1,2,4]triazolo[4,3-a]pyridin-6-yl)sulfanyl]benzyl}urea, 2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine, MITOGEN-ACTIVATED PROTEIN KINASE 14 | Authors: | Millan, D.S, Anderson, M, Bazin, R, Bunnage, M.E, Burrows, J.L, Butcher, K.J, Dodd, P.G, Evans, T.J, Fairman, D.A, Hughes, S.J, Irving, S.L, Kilty, I.C, Lemaitre, A, Lewthwaite, R.A, Mahnke, A, Mathais, J.P, Philip, J, Phillips, C, Smith, R.T, Stefaniack, M.H, Yeadon, M. | Deposit date: | 2011-05-16 | Release date: | 2011-11-30 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Design and Synthesis of Inhaled P38 Inhibitors for the Treatment of Chronic Obstructive Pulmonary Disease. J.Med.Chem., 54, 2011
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6YLK
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![BU of 6ylk by Molmil](/molmil-images/mine/6ylk) | Cdk2(F80C) with Covalent Adduct TK22 at F80C | Descriptor: | Cyclin-dependent kinase 2, methyl 4-ethyl-1-propanoyl-2,3-dihydroquinoxaline-6-carboxylate | Authors: | Craven, G, Morgan, R.M.L, Mann, D.J. | Deposit date: | 2020-04-07 | Release date: | 2020-07-22 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Multiparameter Kinetic Analysis for Covalent Fragment Optimization by Using Quantitative Irreversible Tethering (qIT). Chembiochem, 21, 2020
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5A3G
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![BU of 5a3g by Molmil](/molmil-images/mine/5a3g) | Structure of herpesvirus nuclear egress complex subunit M50 | Descriptor: | M50 | Authors: | Leigh, K.E, Boeszoermenyi, A, Mansueto, M.S, Sharma, M, Filman, D.J, Coen, D.M, Wagner, G, Hogle, J.M, Arthanari, H. | Deposit date: | 2015-06-01 | Release date: | 2015-07-15 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Structure of a Herpesvirus Nuclear Egress Complex Subunit Reveals an Interaction Groove that is Essential for Viral Replication Proc.Natl.Acad.Sci.USA, 112, 2015
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2Z6R
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![BU of 2z6r by Molmil](/molmil-images/mine/2z6r) | Crystal structure of Lys49 to Arg mutant of Diphthine synthase | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Mizutani, H, Matsuura, Y, Krishna Swamy, B.S, Simanshu, D.K, Murthy, M.R.N, Kunishima, N. | Deposit date: | 2007-08-08 | Release date: | 2007-08-28 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Crystal structure of diphthine synthase from Pyrococcus horikoshii OT3 To be Published
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2JY5
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![BU of 2jy5 by Molmil](/molmil-images/mine/2jy5) | NMR structure of Ubiquilin 1 UBA domain | Descriptor: | Ubiquilin-1 | Authors: | Zhang, D, Raasi, S, Fushman, D. | Deposit date: | 2007-12-06 | Release date: | 2008-03-18 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Affinity makes the difference: nonselective interaction of the UBA domain of Ubiquilin-1 with monomeric ubiquitin and polyubiquitin chains J.Mol.Biol., 377, 2008
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2JY6
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![BU of 2jy6 by Molmil](/molmil-images/mine/2jy6) | |
6PQ3
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![BU of 6pq3 by Molmil](/molmil-images/mine/6pq3) | Crystal structure of GDP-bound KRAS with ten residues long internal tandem duplication in the switch II region | Descriptor: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Dharmaiah, S, Chan, A.H, Tran, T.H, Simanshu, D.K. | Deposit date: | 2019-07-08 | Release date: | 2020-05-20 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | RASinternal tandem duplication disrupts GTPase-activating protein (GAP) binding to activate oncogenic signaling. J.Biol.Chem., 295, 2020
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1ZTE
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![BU of 1zte by Molmil](/molmil-images/mine/1zte) | Contribution to Structure and Catalysis of Tyrosine 34 in Human Manganese Suerpoxide Dismutase | Descriptor: | MANGANESE (II) ION, Superoxide dismutase [Mn], mitochondrial | Authors: | Hearn, A.S, Perry, J.J, Cabelii, D.E, Tainer, J.A, Nick, H.S, Silverman, D.S. | Deposit date: | 2005-05-26 | Release date: | 2006-05-02 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Contribution of human manganese superoxide dismutase tyrosine 34 to structure and catalysis. Biochemistry, 48, 2009
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2XK5
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![BU of 2xk5 by Molmil](/molmil-images/mine/2xk5) | |
2Y5Z
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![BU of 2y5z by Molmil](/molmil-images/mine/2y5z) | Mixed-function P450 MycG in complex with mycinamicin III in C2221 space group | Descriptor: | BENZAMIDINE, GLYCEROL, MYCINAMICIN III, ... | Authors: | Li, S, Kells, P.M, Sherman, D.H, Podust, L.M. | Deposit date: | 2011-01-19 | Release date: | 2012-02-01 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | Substrate Recognition by the Multifunctional Cytochrome P450 Mycg in Mycinamicin Hydroxylation and Epoxidation Reactions. J.Biol.Chem., 287, 2012
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6YL1
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![BU of 6yl1 by Molmil](/molmil-images/mine/6yl1) | Cdk2(F80C) with Covalent Adduct TK37 at F80C | Descriptor: | Cyclin-dependent kinase 2, methyl 4-(cyclopropylmethyl)-1-prop-2-enoyl-2,3-dihydroquinoxaline-6-carboxylate | Authors: | Craven, G, Morgan, R.M.L, Mann, D.J. | Deposit date: | 2020-04-06 | Release date: | 2020-07-22 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | Multiparameter Kinetic Analysis for Covalent Fragment Optimization by Using Quantitative Irreversible Tethering (qIT). Chembiochem, 21, 2020
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2Y3S
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![BU of 2y3s by Molmil](/molmil-images/mine/2y3s) | Structure of the tirandamycine-bound FAD-dependent tirandamycin oxidase TamL in C2 space group | Descriptor: | CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | Authors: | Carlson, J.C, Li, S, Gunatilleke, S.S, Anzai, Y, Burr, D.A, Podust, L.M, Sherman, D.H. | Deposit date: | 2010-12-23 | Release date: | 2011-06-29 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Tirandamycin Biosynthesis is Mediated by Co-Dependent Oxidative Enzymes Nat.Chem, 3, 2011
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244D
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![BU of 244d by Molmil](/molmil-images/mine/244d) | THE HIGH-RESOLUTION CRYSTAL STRUCTURE OF A PARALLEL-STRANDED GUANINE TETRAPLEX | Descriptor: | CALCIUM ION, DNA (5'-D(*TP*GP*GP*GP*GP*T)-3'), SODIUM ION | Authors: | Laughlan, G, Murchie, A.I.H, Norman, D.G, Moore, M.H, Moody, P.C.E, Lilley, D.M.J, Luisi, B. | Deposit date: | 1995-10-19 | Release date: | 1996-02-23 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | The high-resolution crystal structure of a parallel-stranded guanine tetraplex. Science, 265, 1994
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2Y08
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![BU of 2y08 by Molmil](/molmil-images/mine/2y08) | Structure of the substrate-free FAD-dependent tirandamycin oxidase TamL | Descriptor: | CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | Authors: | Carlson, J.C, Li, S, Gunatilleke, S.S, Anzai, Y, Burr, D.A, Podust, L.M, Sherman, D.H. | Deposit date: | 2010-11-30 | Release date: | 2011-06-29 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Tirandamycin Biosynthesis is Mediated by Co-Dependent Oxidative Enzymes Nat.Chem, 3, 2011
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2Y46
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![BU of 2y46 by Molmil](/molmil-images/mine/2y46) | Structure of the mixed-function P450 MycG in complex with mycinamicin IV in C 2 2 21 space group | Descriptor: | BENZAMIDINE, GLYCEROL, MYCINAMICIN IV, ... | Authors: | Li, S, Kells, P.M, Sherman, D.H, Podust, L.M. | Deposit date: | 2011-01-05 | Release date: | 2012-01-25 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Substrate Recognition by the Multifunctional Cytochrome P450 Mycg in Mycinamicin Hydroxylation and Epoxidation Reactions. J.Biol.Chem., 287, 2012
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2Y5N
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![BU of 2y5n by Molmil](/molmil-images/mine/2y5n) | Structure of the mixed-function P450 MycG in complex with mycinamicin V in P21 space group | Descriptor: | GLYCEROL, MAGNESIUM ION, MYCINAMICIN V, ... | Authors: | Li, S, Kells, P.M, Sherman, D.H, Podust, L.M. | Deposit date: | 2011-01-15 | Release date: | 2012-02-01 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.62 Å) | Cite: | Substrate Recognition by the Multifunctional Cytochrome P450 Mycg in Mycinamicin Hydroxylation and Epoxidation Reactions. J.Biol.Chem., 287, 2012
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6YXR
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![BU of 6yxr by Molmil](/molmil-images/mine/6yxr) | Dunaliella Minimal Photosystem I | Descriptor: | (3R,3'R,6S)-4,5-DIDEHYDRO-5,6-DIHYDRO-BETA,BETA-CAROTENE-3,3'-DIOL, (3S,5R,6S,3'S,5'R,6'S)-5,6,5',6'-DIEPOXY-5,6,5',6'- TETRAHYDRO-BETA,BETA-CAROTENE-3,3'-DIOL, 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, ... | Authors: | Nelson, N, Caspy, I, Malavath, T, Klaiman, D, Shkolinsky, Y. | Deposit date: | 2020-05-03 | Release date: | 2020-07-01 | Last modified: | 2020-07-15 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure and energy transfer pathways of the Dunaliella Salina photosystem I supercomplex. Biochim Biophys Acta Bioenerg, 1861, 2020
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2Y5B
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![BU of 2y5b by Molmil](/molmil-images/mine/2y5b) | Structure of USP21 in complex with linear diubiquitin-aldehyde | Descriptor: | SULFATE ION, UBIQUITIN, UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21, ... | Authors: | Ye, Y, Akutsu, M, Reyes-Turcu, F, Enchev, R.I, Wilkinson, K.D, Komander, D. | Deposit date: | 2011-01-12 | Release date: | 2012-01-25 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Polyubiquitin Binding and Cross-Reactivity in the Usp Domain Deubiquitinase Usp21. Embo Rep., 12, 2011
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6ZET
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![BU of 6zet by Molmil](/molmil-images/mine/6zet) | Crystal structure of proteinase K nanocrystals by electron diffraction with a 20 micrometre C2 condenser aperture | Descriptor: | CALCIUM ION, Proteinase K | Authors: | Evans, G, Zhang, P, Beale, E.V, Waterman, D.G. | Deposit date: | 2020-06-16 | Release date: | 2020-10-14 | Last modified: | 2024-02-14 | Method: | ELECTRON CRYSTALLOGRAPHY (2.701 Å) | Cite: | A Workflow for Protein Structure Determination From Thin Crystal Lamella by Micro-Electron Diffraction. Front Mol Biosci, 7, 2020
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6ZEV
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![BU of 6zev by Molmil](/molmil-images/mine/6zev) | Crystal structure of proteinase K lamellae by electron diffraction with a 20 micrometre C2 condenser aperture | Descriptor: | CALCIUM ION, Proteinase K | Authors: | Evans, G, Zhang, P, Beale, E.V, Waterman, D.G. | Deposit date: | 2020-06-16 | Release date: | 2020-10-14 | Last modified: | 2024-02-14 | Method: | ELECTRON CRYSTALLOGRAPHY (2.4 Å) | Cite: | A Workflow for Protein Structure Determination From Thin Crystal Lamella by Micro-Electron Diffraction. Front Mol Biosci, 7, 2020
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2Y98
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![BU of 2y98 by Molmil](/molmil-images/mine/2y98) | Structure of the mixed-function P450 MycG in complex with mycinamicin IV in P21212 space group | Descriptor: | CHLORIDE ION, GLYCEROL, MYCINAMICIN IV, ... | Authors: | Li, S, Kells, P.M, Sherman, D.H, Podust, L.M. | Deposit date: | 2011-02-12 | Release date: | 2012-02-22 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Substrate Recognition by the Multifunctional Cytochrome P450 Mycg in Mycinamicin Hydroxylation and Epoxidation Reactions. J.Biol.Chem., 287, 2012
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2YND
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![BU of 2ynd by Molmil](/molmil-images/mine/2ynd) | Plasmodium vivax N-myristoyltransferase in complex with a pyrazole sulphonamide inhibitor. | Descriptor: | 2,6-dichloro-4-(2-piperazin-1-ylpyridin-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide, 2-oxopentadecyl-CoA, CHLORIDE ION, ... | Authors: | Wright, M.H, Clough, B, Rackham, M.D, Brannigan, J.A, Grainger, M, Bottrill, A.R, Heal, W.P, Broncel, M, Serwa, R.A, Mann, D, Leatherbarrow, R.J, Wilkinson, A.J, Holder, A.A, Tate, E.W. | Deposit date: | 2012-10-13 | Release date: | 2014-01-15 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Validation of N-Myristoyltransferase as an Antimalarial Drug Target Using an Integrated Chemical Biology Approach. Nat.Chem., 6, 2014
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