7MVX
 
 | | Crystal structure of the Chaetomium thermophilum Nup188-Nic96 complex (Nup188 residues 1-1858; Nic96 residues 240-301) | | Descriptor: | Nucleoporin NIC96, Nucleoporin NUP188 | | Authors: | Petrovic, S, Samanta, D, Perriches, T, Bley, C.J, Thierbach, K, Brown, B, Nie, S, Mobbs, G.W, Stevens, T.A, Liu, X, Tomaleri, G.P, Schaus, L, Hoelz, A. | | Deposit date: | 2021-05-15 | | Release date: | 2022-06-15 | | Last modified: | 2022-06-22 | | Method: | X-RAY DIFFRACTION (4.35 Å) | | Cite: | Architecture of the linker-scaffold in the nuclear pore.
Science, 376, 2022
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2AYR
 | | A SERM Designed for the Treatment of Uterine Leiomyoma with Unique Tissue Specificity for Uterus and Ovaries in Rats | | Descriptor: | 6-(4-METHYLSULFONYL-PHENYL)-5-[4-(2-PIPERIDIN-1-YLETHOXY)PHENOXY]NAPHTHALEN-2-OL, Estrogen receptor | | Authors: | Hummel, C.W, Geiser, A.G, Bryant, H.U, Cohen, I.R, Dally, R.D, Fong, K.C, Frank, S.A, Hinklin, R, Jones, S.A, Lewis, G, McCann, D.J, Shepherd, T.A, Tian, H, Rudman, D.G, Wallace, O.B, Wang, Y, Dodge, J.A. | | Deposit date: | 2005-09-07 | | Release date: | 2005-11-22 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | A selective estrogen receptor modulator designed for the treatment of uterine leiomyoma with unique tissue specificity for uterus and ovaries in rats
J.Med.Chem., 48, 2005
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3TWZ
 | | Phosphorylated Bacillus cereus phosphopentomutase in space group P212121 | | Descriptor: | MANGANESE (II) ION, Phosphopentomutase | | Authors: | Panosian, T.P, Nanneman, D.P, Bachmann, B.O, Iverson, T.M. | | Deposit date: | 2011-09-22 | | Release date: | 2012-02-29 | | Last modified: | 2012-03-21 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Molecular Differences between a Mutase and a Phosphatase: Investigations of the Activation Step in Bacillus cereus Phosphopentomutase.
Biochemistry, 51, 2012
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8STM
 | | Crystal structure of KRAS-G75A mutant, GDP-bound | | Descriptor: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | | Authors: | Tran, T.H, Dharmaiah, S, Simanshu, D.K. | | Deposit date: | 2023-05-10 | | Release date: | 2023-08-23 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Allosteric Regulation of Switch-II Domain Controls KRAS Oncogenicity.
Cancer Res., 83, 2023
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3TX0
 | | Unphosphorylated Bacillus cereus phosphopentomutase in a P212121 crystal form | | Descriptor: | MANGANESE (II) ION, Phosphopentomutase | | Authors: | Panosian, T.P, Nanneman, D.P, Bachmann, B.O, Iverson, T.M. | | Deposit date: | 2011-09-22 | | Release date: | 2012-02-29 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.26 Å) | | Cite: | Molecular Differences between a Mutase and a Phosphatase: Investigations of the Activation Step in Bacillus cereus Phosphopentomutase.
Biochemistry, 51, 2012
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1BKF
 | | FK506 BINDING PROTEIN FKBP MUTANT R42K/H87V COMPLEX WITH IMMUNOSUPPRESSANT FK506 | | Descriptor: | 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, FK506 BINDING PROTEIN | | Authors: | Itoh, S, Decenzo, M.T, Livingston, D.J, Pearlman, D.A, Navia, M.A. | | Deposit date: | 1995-10-18 | | Release date: | 1996-08-01 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Conformation of Fk506 in X-Ray Structures of its Complexes with Human Recombinant Fkbp12 Mutants
Bioorg.Med.Chem.Lett., 5, 1995
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2C04
 | | GMPPCP complex of SRP GTPase Ffh NG Domain at ultra-high resolution | | Descriptor: | CALCIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, SIGNAL RECOGNITION PARTICLE PROTEIN | | Authors: | Ramirez, U.D, Preininger, A.M, Freymann, D.M. | | Deposit date: | 2005-08-25 | | Release date: | 2007-02-13 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.15 Å) | | Cite: | Nucleotide-Binding Flexibility in Ultrahigh-Resolution Structures of the Srp Gtpase Ffh
Acta Crystallogr.,Sect.D, 64, 2008
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2C03
 | | GDP COMPLEX OF SRP GTPASE FFH NG DOMAIN | | Descriptor: | 1,2-ETHANEDIOL, 1,4-DIETHYLENE DIOXIDE, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Ramirez, U.D, Preininger, A.M, Freymann, D.M. | | Deposit date: | 2005-08-25 | | Release date: | 2007-02-13 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.24 Å) | | Cite: | Nucleotide-Binding Flexibility in Ultrahigh-Resolution Structures of the Srp Gtpase Ffh
Acta Crystallogr.,Sect.D, 64, 2008
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1CII
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8T71
 | | Crystal Structure of WT KRAS4a with bound GDP and Mg ion | | Descriptor: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | | Authors: | Tran, T.H, Whitley, M.J, Dharmaiah, S, Simanshu, D.K. | | Deposit date: | 2023-06-19 | | Release date: | 2024-02-14 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Comparative analysis of KRAS4a and KRAS4b splice variants reveals distinctive structural and functional properties.
Sci Adv, 10, 2024
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8T72
 | | Crystal structure of WT KRAS4a with bound GMPPNP and Mg ion | | Descriptor: | GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | | Authors: | Tran, T.H, Whitley, M.J, Dharmaiah, S, Simanshu, D.K. | | Deposit date: | 2023-06-19 | | Release date: | 2024-02-14 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Comparative analysis of KRAS4a and KRAS4b splice variants reveals distinctive structural and functional properties.
Sci Adv, 10, 2024
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1NHN
 | | THE STRUCTURE OF THE HMG BOX AND ITS INTERACTION WITH DNA | | Descriptor: | HIGH MOBILITY GROUP PROTEIN 1 | | Authors: | Read, C.M, Cary, P.D, Crane-Robinson, C, Driscoll, P.C, Carillo, M.O.M, Norman, D.G. | | Deposit date: | 1994-11-17 | | Release date: | 1995-02-07 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | The Structure of the Hmg Box and its Interaction with DNA
NUCLEIC ACIDS MOL.BIOL., 9, 1995
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1C9W
 | | CHO REDUCTASE WITH NADP+ | | Descriptor: | CHO REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | Authors: | Ye, Q, Li, X, Hyndman, D, Flynn, T.G, Jia, Z. | | Deposit date: | 1999-08-03 | | Release date: | 2000-01-07 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structure of CHO reductase, a member of the aldo-keto reductase superfamily.
Proteins, 38, 2000
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1NHM
 | | THE STRUCTURE OF THE HMG BOX AND ITS INTERACTION WITH DNA | | Descriptor: | HIGH MOBILITY GROUP PROTEIN 1 | | Authors: | Read, C.M, Cary, P.D, Crane-Robinson, C, Driscoll, P.C, Carillo, M.O.M, Norman, D.G. | | Deposit date: | 1994-11-17 | | Release date: | 1995-02-07 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | The Structure of the Hmg Box and its Interaction with DNA
NUCLEIC ACIDS MOL.BIOL., 9, 1995
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1O0S
 | | Crystal Structure of Ascaris suum Malic Enzyme Complexed with NADH | | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, NAD-dependent malic enzyme, TARTRONATE | | Authors: | Rao, G.S, Coleman, D.E, Karsten, W.E, Cook, P.F, Harris, B.G. | | Deposit date: | 2003-02-24 | | Release date: | 2003-07-22 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystallographic studies on Ascaris suum NAD-malic enzyme bound to reduced cofactor and identification of an effector site.
J.Biol.Chem., 278, 2003
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7T39
 | | Co-crystal structure of human PRMT9 in complex with MT221 inhibitor | | Descriptor: | 7-[5-S-(4-{[(2-ethylpyridin-3-yl)methyl]amino}butyl)-5-thio-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Protein arginine N-methyltransferase 9 | | Authors: | Zeng, H, Dong, A, Hutchinson, A, Seitova, A, Li, Y, Gao, Y.D, Schneider, S, Siliphaivanh, P, Sloman, D, Nicholson, B, Fischer, C, Hicks, J, Brown, P.J, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | | Deposit date: | 2021-12-07 | | Release date: | 2021-12-22 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.81 Å) | | Cite: | Co-crystal structure of human PRMT9 in complex with MT221 inhibitor
To Be Published
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7T3X
 | | Structure of unphosphorylated Pediculus humanus (Ph) PINK1 D334A mutant | | Descriptor: | Serine/threonine-protein kinase PINK1 | | Authors: | Gan, Z.Y, Leis, A, Dewson, G, Glukhova, A, Komander, D. | | Deposit date: | 2021-12-09 | | Release date: | 2021-12-22 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3.53 Å) | | Cite: | Activation mechanism of PINK1.
Nature, 602, 2022
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1ZUQ
 | | Contribution to Structure and Catalysis of Tyrosine 34 in Human Manganese Superoxide Dismutase | | Descriptor: | MANGANESE (II) ION, Superoxide dismutase | | Authors: | Hearn, A.S, Perry, J.J, Cabelii, D.E, Tainer, J.A, Nick, H.S, Silverman, D.S. | | Deposit date: | 2005-05-31 | | Release date: | 2006-05-02 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Contribution of human manganese superoxide dismutase tyrosine 34 to structure and catalysis.
Biochemistry, 48, 2009
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7T4K
 | | Structure of dimeric phosphorylated Pediculus humanus (Ph) PINK1 with kinked alpha-C helix in chain B | | Descriptor: | Serine/threonine-protein kinase PINK1, putative | | Authors: | Gan, Z.Y, Leis, A, Dewson, G, Glukhova, A, Komander, D. | | Deposit date: | 2021-12-10 | | Release date: | 2022-01-12 | | Last modified: | 2022-02-23 | | Method: | ELECTRON MICROSCOPY (3.25 Å) | | Cite: | Activation mechanism of PINK1.
Nature, 602, 2022
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7T4N
 | | Structure of dimeric unphosphorylated Pediculus humanus (Ph) PINK1 D357A mutant | | Descriptor: | Serine/threonine-protein kinase PINK1, putative | | Authors: | Gan, Z.Y, Leis, A, Dewson, G, Glukhova, A, Komander, D. | | Deposit date: | 2021-12-10 | | Release date: | 2022-01-12 | | Last modified: | 2024-02-28 | | Method: | ELECTRON MICROSCOPY (2.35 Å) | | Cite: | Activation mechanism of PINK1.
Nature, 602, 2022
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7T4L
 | | Structure of dimeric phosphorylated Pediculus humanus (Ph) PINK1 with extended alpha-C helix in chain B | | Descriptor: | Serine/threonine-protein kinase PINK1, putative | | Authors: | Gan, Z.Y, Leis, A, Dewson, G, Glukhova, A, Komander, D. | | Deposit date: | 2021-12-10 | | Release date: | 2022-01-12 | | Last modified: | 2022-02-23 | | Method: | ELECTRON MICROSCOPY (3.28 Å) | | Cite: | Activation mechanism of PINK1.
Nature, 602, 2022
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1ZSP
 | | Contribution to Structure and Catalysis of Tyrosine 34 in Human Manganese Superoxide Dismutase | | Descriptor: | MANGANESE (II) ION, Superoxide dismutase [Mn], mitochondrial | | Authors: | Hearn, A.S, Perry, J.J, Cabelli, D.E, Tainer, J.A, Nick, H.S, Silverman, D.S. | | Deposit date: | 2005-05-24 | | Release date: | 2006-05-02 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Contribution of human manganese superoxide dismutase tyrosine 34 to structure and catalysis.
Biochemistry, 48, 2009
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6V65
 | | Crystal structure of KRAS(GMPPNP)-NF1(GRD)-SPRED1 complex | | Descriptor: | FORMIC ACID, GTPase KRas, MAGNESIUM ION, ... | | Authors: | Yan, W, Simanshu, D.K. | | Deposit date: | 2019-12-04 | | Release date: | 2020-07-15 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.763 Å) | | Cite: | Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR.
Cell Rep, 32, 2020
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7SWP
 | | G32Q4 Fab in complex with SARS-CoV-2 Spike 6P (RBD local reconstruction) | | Descriptor: | G32Q4 Fab heavy chain, G32Q4 Fab light chain, Spike protein S1 | | Authors: | Windsor, I.W, Tong, P, Wesemann, D.R, Harrison, S.C. | | Deposit date: | 2021-11-20 | | Release date: | 2022-04-27 | | Last modified: | 2022-11-09 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Antibodies induced by an ancestral SARS-CoV-2 strain that cross-neutralize variants from Alpha to Omicron BA.1.
Sci Immunol, 7, 2022
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1DPS
 | | THE CRYSTAL STRUCTURE OF DPS, A FERRITIN HOMOLOG THAT BINDS AND PROTECTS DNA | | Descriptor: | DPS, SODIUM ION | | Authors: | Grant, R.A, Filman, D.J, Finkel, S.E, Kolter, R, Hogle, J.M. | | Deposit date: | 1998-02-23 | | Release date: | 1998-09-16 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | The crystal structure of Dps, a ferritin homolog that binds and protects DNA.
Nat.Struct.Biol., 5, 1998
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