7O0E
| Crystal structure of GH30 (mutant E188A) complexed with aldotriuronic acid from Thermothelomyces thermophila. | Descriptor: | 1,2-ETHANEDIOL, 4-O-methyl-alpha-D-glucopyranuronic acid-(1-2)-beta-D-xylopyranose-(1-4)-beta-D-xylopyranose, DI(HYDROXYETHYL)ETHER, ... | Authors: | Dimarogona, M, Kosinas, C, Feiler, C, Weiss, M.S, Topakas, E, Nikolaivits, E. | Deposit date: | 2021-03-26 | Release date: | 2021-09-08 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Unique features of the bifunctional GH30 from Thermothelomyces thermophila revealed by structural and mutational studies Carbohydrate Polymers, 273, 2021
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3G7Y
| Crystal structure of oxidized Ost6L | Descriptor: | Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit OST6 | Authors: | Stirnimann, C.U, Grimshaw, J.P.A, Schulz, B.L, Brozzo, M.S, Fritsch, F, Glockshuber, R, Capitani, G, Gruetter, M.G, Aebi, M. | Deposit date: | 2009-02-11 | Release date: | 2009-06-16 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.215 Å) | Cite: | Oxidoreductase activity of oligosaccharyltransferase subunits Ost3p and Ost6p defines site-specific glycosylation efficiency. Proc.Natl.Acad.Sci.USA, 106, 2009
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3GA4
| Crystal structure of Ost6L (photoreduced form) | Descriptor: | 1,2-ETHANEDIOL, Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit OST6, TETRAETHYLENE GLYCOL | Authors: | Stirnimann, C.U, Grimshaw, J.P.A, Schulz, B.L, Brozzo, M.S, Fritsch, F, Glockshuber, R, Capitani, G, Gruetter, M.G, Aebi, M. | Deposit date: | 2009-02-16 | Release date: | 2009-06-16 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Oxidoreductase activity of oligosaccharyltransferase subunits Ost3p and Ost6p defines site-specific glycosylation efficiency. Proc.Natl.Acad.Sci.USA, 106, 2009
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5ZK8
| Crystal structure of M2 muscarinic acetylcholine receptor bound with NMS | Descriptor: | Muscarinic acetylcholine receptor M2,Redesigned apo-cytochrome b562,Muscarinic acetylcholine receptor M2, N-methyl scopolamine | Authors: | Suno, R, Maeda, S, Yasuda, S, Yamashita, K, Hirata, K, Horita, S, Tawaramoto, M.S, Tsujimoto, H, Murata, T, Kinoshita, M, Yamamoto, M, Kobilka, B.K, Iwata, S, Kobayashi, T. | Deposit date: | 2018-03-23 | Release date: | 2018-11-21 | Last modified: | 2022-03-23 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural insights into the subtype-selective antagonist binding to the M2muscarinic receptor Nat. Chem. Biol., 14, 2018
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5ZKB
| Crystal structure of rationally thermostabilized M2 muscarinic acetylcholine receptor bound with AF-DX 384 | Descriptor: | Muscarinic acetylcholine receptor M2,Apo-cytochrome b562,Muscarinic acetylcholine receptor M2, N-[2-[(2S)-2-[(dipropylamino)methyl]piperidin-1-yl]ethyl]-6-oxidanylidene-5H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide | Authors: | Suno, R, Maeda, S, Yasuda, S, Yamashita, K, Hirata, K, Horita, S, Tawaramoto, M.S, Tsujimoto, H, Murata, T, Kinoshita, M, Yamamoto, M, Kobilka, B.K, Iwata, S, Kobayashi, T. | Deposit date: | 2018-03-23 | Release date: | 2018-11-21 | Last modified: | 2022-03-23 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Structural insights into the subtype-selective antagonist binding to the M2muscarinic receptor Nat. Chem. Biol., 14, 2018
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6NEO
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1UO6
| PORCINE PANCREATIC ELASTASE/Xe-COMPLEX | Descriptor: | CHLORIDE ION, ELASTASE 1, GLYCEROL, ... | Authors: | Mueller-Dieckmann, C, Polentarutti, M, Djinovic-Carugo, K, Panjikar, S, Tucker, P.A, Weiss, M.S. | Deposit date: | 2003-09-16 | Release date: | 2003-10-14 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | On the Routine Use of Soft X-Rays in Macromolecular Crystallography. Part II. Data-Collection Wavelength and Scaling Models Acta Crystallogr.,Sect.D, 60, 2004
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1UOU
| Crystal structure of human thymidine phosphorylase in complex with a small molecule inhibitor | Descriptor: | 5-CHLORO-6-(1-(2-IMINOPYRROLIDINYL) METHYL) URACIL, THYMIDINE PHOSPHORYLASE | Authors: | Norman, R.A, Barry, S.T, Bate, M, Breed, J, Colls, J.G, Ernill, R.J, Luke, R.W.A, Minshull, C.A, McAlister, M.S.B, McCall, E.J, McMiken, H.H.J, Paterson, D.S, Timms, D, Tucker, J.A, Pauptit, R.A. | Deposit date: | 2003-09-23 | Release date: | 2004-01-22 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Crystal Structure of Human Thymidine Phosphorylase in Complex with a Small Molecule Inhibitor Structure, 12, 2004
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4V47
| Real space refined coordinates of the 30S and 50S subunits fitted into the low resolution cryo-EM map of the EF-G.GTP state of E. coli 70S ribosome | Descriptor: | 16S RIBOSOMAL RNA, 23S ribosomal RNA, 30S RIBOSOMAL PROTEIN S10, ... | Authors: | Gao, H, Sengupta, J, Valle, M, Korostelev, A, Eswar, N, Stagg, S.M, Van Roey, P, Agrawal, R.K, Harvey, S.T, Sali, A, Chapman, M.S, Frank, J. | Deposit date: | 2003-05-06 | Release date: | 2014-07-09 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (12.3 Å) | Cite: | Study of the structural dynamics of the E. coli 70S ribosome using real space refinement Cell(Cambridge,Mass.), 113, 2003
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5COD
| Bovine heart complex I membrane domain | Descriptor: | NADH-ubiquinone oxidoreductase chain 4, NADH-ubiquinone oxidoreductase chain 5, SDAP, ... | Authors: | Zhu, J, Hirst, J, King, M.S, Yu, M, Leslie, A.G.W, Klipcan, L. | Deposit date: | 2015-07-20 | Release date: | 2015-09-23 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (6.74 Å) | Cite: | Structure of subcomplex I beta of mammalian respiratory complex I leads to new supernumerary subunit assignments. Proc.Natl.Acad.Sci.USA, 112, 2015
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5ZE2
| Hairpin Complex, RAG1/2-hairpin 12RSS/23RSS complex in 5mM Mn2+ for 2 min at 4'C | Descriptor: | 1,2-ETHANEDIOL, DNA (30-MER), DNA (31-MER), ... | Authors: | Kim, M.S, Chuenchor, W, Chen, X, Gellert, M, Yang, W. | Deposit date: | 2018-02-25 | Release date: | 2018-04-25 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Cracking the DNA Code for V(D)J Recombination Mol. Cell, 70, 2018
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8B8J
| Cryo-EM structure of Ca2+-bound mTMEM16F F518H mutant in Digitonin | Descriptor: | Anoctamin-6, CALCIUM ION | Authors: | Arndt, M, Alvadia, C, Straub, M.S, Clerico Mosina, V, Paulino, C, Dutzler, R. | Deposit date: | 2022-10-04 | Release date: | 2022-11-16 | Method: | ELECTRON MICROSCOPY (2.96 Å) | Cite: | Structural basis for the activation of the lipid scramblase TMEM16F. Nat Commun, 13, 2022
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8B8M
| Cryo-EM structure of Ca2+-bound mTMEM16F N562A mutant in Digitonin open/closed | Descriptor: | Anoctamin-6, CALCIUM ION | Authors: | Arndt, M, Alvadia, C, Straub, M.S, Clerico-Mosina, V, Paulino, C, Dutzler, R. | Deposit date: | 2022-10-04 | Release date: | 2022-11-16 | Method: | ELECTRON MICROSCOPY (3.49 Å) | Cite: | Structural basis for the activation of the lipid scramblase TMEM16F. Nat Commun, 13, 2022
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8B1U
| RecBCD-DNA in complex with the phage protein Abc2 and host PpiB | Descriptor: | Anti-RecBCD protein 2, DNA (70-MER), MAGNESIUM ION, ... | Authors: | Wilkinson, M, Wilkinson, O.J, Feyerherm, C, Fletcher, E.E, Wigley, D.B, Dillingham, M.S. | Deposit date: | 2022-09-12 | Release date: | 2022-12-28 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structures of RecBCD in complex with phage-encoded inhibitor proteins reveal distinctive strategies for evasion of a bacterial immunity hub. Elife, 11, 2022
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8B1R
| RecBCD in complex with the phage protein gp5.9 | Descriptor: | MAGNESIUM ION, Probable RecBCD inhibitor gp5.9, RecBCD enzyme subunit RecB, ... | Authors: | Wilkinson, M, Wilkinson, O.J, Feyerherm, C, Fletcher, E.E, Wigley, D.B, Dillingham, M.S. | Deposit date: | 2022-09-12 | Release date: | 2022-12-28 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structures of RecBCD in complex with phage-encoded inhibitor proteins reveal distinctive strategies for evasion of a bacterial immunity hub. Elife, 11, 2022
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8B8Q
| Structure of mTMEM16F in lipid Nanodiscs in the presence of Ca2+ | Descriptor: | Anoctamin-6, CALCIUM ION | Authors: | Arndt, M, Alvadia, C, Straub, M.S, Clerico-Mosina, V, Paulino, C, Dutzler, R. | Deposit date: | 2022-10-04 | Release date: | 2022-12-21 | Method: | ELECTRON MICROSCOPY (2.94 Å) | Cite: | Structural basis for the activation of the lipid scramblase TMEM16F. Nat Commun, 13, 2022
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8B1T
| RecBCD-DNA in complex with the phage protein Abc2 | Descriptor: | Anti-RecBCD protein 2, DNA (70-MER), MAGNESIUM ION, ... | Authors: | Wilkinson, M, Wilkinson, O.J, Feyerherm, C, Fletcher, E.E, Wigley, D.B, Dillingham, M.S. | Deposit date: | 2022-09-12 | Release date: | 2022-12-28 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structures of RecBCD in complex with phage-encoded inhibitor proteins reveal distinctive strategies for evasion of a bacterial immunity hub. Elife, 11, 2022
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8ANP
| Legionella effector Lem3 mutant D190A in complex with Mg2+ | Descriptor: | MAGNESIUM ION, Phosphocholine hydrolase Lem3, SULFATE ION, ... | Authors: | Kaspers, M.S, Pogenberg, V, Ernst, S, Ecker, F, Pett, C, Ochtrop, P, Hedberg, C, Groll, M, Itzen, A. | Deposit date: | 2022-08-05 | Release date: | 2023-04-12 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Dephosphocholination by Legionella effector Lem3 functions through remodelling of the switch II region of Rab1b. Nat Commun, 14, 2023
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7TPJ
| Single-Particle Cryo-EM Structure of the WaaL O-antigen ligase in its apo state | Descriptor: | Fab Heavy (H) Chain, Fab Light (L) Chain, Putative cell surface polysaccharide polymerase/ligase | Authors: | Ashraf, K.U, Nygaard, R, Vickery, O.N, Erramilli, S.K, Herrera, C.M, McConville, T.H, Petrou, V.I, Giacometti, S.I, Dufrisne, M.B, Nosol, K, Zinkle, A.P, Graham, C.L.B, Loukeris, M, Kloss, B, Skorupinska-Tudek, K, Swiezewska, E, Roper, D, Clarke, O.B, Uhlemann, A.C, Kossiakoff, A.A, Trent, M.S, Stansfeld, P.J, Mancia, F. | Deposit date: | 2022-01-25 | Release date: | 2022-04-06 | Last modified: | 2022-04-27 | Method: | ELECTRON MICROSCOPY (3.46 Å) | Cite: | Structural basis of lipopolysaccharide maturation by the O-antigen ligase. Nature, 604, 2022
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7TPG
| Single-Particle Cryo-EM Structure of the WaaL O-antigen ligase in its ligand bound state | Descriptor: | Fab Heavy (H) Chain, Fab Light (L) Chain, GERANYL DIPHOSPHATE, ... | Authors: | Ashraf, K.U, Nygaard, R, Vickery, O.N, Erramilli, S.K, Herrera, C.M, McConville, T.H, Petrou, V.I, Giacometti, S.I, Dufrisne, M.B, Nosol, K, Zinkle, A.P, Graham, C.L.B, Loukeris, M, Kloss, B, Skorupinska-Tudek, K, Swiezewska, E, Roper, D, Clarke, O.B, Uhlemann, A.C, Kossiakoff, A.A, Trent, M.S, Stansfeld, P.J, Mancia, F. | Deposit date: | 2022-01-25 | Release date: | 2022-04-06 | Last modified: | 2022-04-27 | Method: | ELECTRON MICROSCOPY (3.23 Å) | Cite: | Structural basis of lipopolysaccharide maturation by the O-antigen ligase. Nature, 604, 2022
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4RYL
| Human Protein Arginine Methyltransferase 3 in complex with 1-isoquinolin-6-yl-3-[2-oxo-2-(pyrrolidin-1-yl)ethyl]urea | Descriptor: | 1-isoquinolin-6-yl-3-[2-oxo-2-(pyrrolidin-1-yl)ethyl]urea, PRMT3 protein, UNKNOWN ATOM OR ION | Authors: | Dong, A, Dobrovetsky, E, Kaniskan, H.U, Szewczyk, M, Yu, Z, Eram, M.S, Yang, X, Schmidt, K, Luo, X, Dai, M, He, F, Zang, I, Lin, Y, Kennedy, S, Li, F, Tempel, W, Smil, D, Min, S.J, Landon, M, Lin-Jones, J, Huang, X.P, Roth, B.L, Schapira, M, Atadja, P, Barsyte-Lovejoy, D, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Brown, P.J, Zhao, K, Jin, J, Vedadi, M, Structural Genomics Consortium (SGC) | Deposit date: | 2014-12-15 | Release date: | 2015-02-25 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A Potent, Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3). Angew.Chem.Int.Ed.Engl., 54, 2015
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6G5X
| Crystal Structure of KDM4A with compound YP-02-145 | Descriptor: | 1,2-ETHANEDIOL, 2-(3-methyl-5-oxidanylidene-4-phenyl-4~{H}-pyrazol-1-yl)-3~{H}-benzimidazole-5-carboxylic acid, CITRIC ACID, ... | Authors: | Malecki, P.H, Carter, D.M, Gohlke, U, Specker, E, Nazare, M, Weiss, M.S, Heinemann, U. | Deposit date: | 2018-03-30 | Release date: | 2019-04-10 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Enhanced Properties of a Benzimidazole Benzylpyrazole Lysine Demethylase Inhibitor: Mechanism-of-Action, Binding Site Analysis, and Activity in Cellular Models of Prostate Cancer. J.Med.Chem., 64, 2021
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2EVN
| NMR solution structures of At1g77540 | Descriptor: | Protein At1g77540 | Authors: | Tyler, R.C, Singh, S, Tonelli, M, Min, M.S, Markley, J.L, Center for Eukaryotic Structural Genomics (CESG) | Deposit date: | 2005-10-31 | Release date: | 2005-11-15 | Last modified: | 2022-03-09 | Method: | SOLUTION NMR | Cite: | Structure of Arabidopsis thaliana At1g77540 Protein, a Minimal Acetyltransferase from the COG2388 Family. Biochemistry, 45, 2006
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4WWX
| Crystal structure of the core RAG1/2 recombinase | Descriptor: | V(D)J recombination-activating protein 1, V(D)J recombination-activating protein 2, ZINC ION | Authors: | Kim, M.S, Lapkouski, M, Yang, W, Gellert, M. | Deposit date: | 2014-11-12 | Release date: | 2015-02-25 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.2001 Å) | Cite: | Crystal structure of the V(D)J recombinase RAG1-RAG2. Nature, 518, 2015
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1BA9
| THE SOLUTION STRUCTURE OF REDUCED MONOMERIC SUPEROXIDE DISMUTASE, NMR, 36 STRUCTURES | Descriptor: | COPPER (I) ION, SUPEROXIDE DISMUTASE, ZINC ION | Authors: | Banci, L, Benedetto, M, Bertini, I, Del Conte, R, Piccioli, M, Viezzoli, M.S. | Deposit date: | 1998-04-24 | Release date: | 1998-09-16 | Last modified: | 2021-11-03 | Method: | SOLUTION NMR | Cite: | Solution structure of reduced monomeric Q133M2 copper, zinc superoxide dismutase (SOD). Why is SOD a dimeric enzyme?. Biochemistry, 37, 1998
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