3ZNP

IN VITRO AND IN VIVO INHIBITION OF HUMAN D-AMINO ACID OXIDASE: REGULATION OF D-SERINE CONCENTRATION IN THE BRAIN

Summary for 3ZNP

Entry DOI	10.2210/pdb3znp/pdb
Related	3ZNN 3ZNO 3ZNQ
Descriptor	D-AMINO-ACID OXIDASE, FLAVIN-ADENINE DINUCLEOTIDE, 3-HYDROXY-2H-CHROMEN-2-ONE, ... (5 entities in total)
Functional Keywords	oxidoreductase, small molecule inhibition, neurotransmission
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Peroxisome: P14920
Total number of polymer chains	2
Total formula weight	81419.72
Authors	Hopkins, S.C.,Heffernan, M.L.R.,Saraswat, L.D.,Bowen, C.A.,Melnick, L.,Hardy, L.W.,Orsini, M.A.,Allen, M.S.,Koch, P.,Spear, K.L.,Foglesong, R.J.,Soukri, M.,Chytil, M.,Fang, Q.K.,Jones, S.W.,Varney, M.A.,Panatier, A.,Oliet, S.H.R.,Pollegioni, L.,Piubelli, L.,Molla, G.,Nardini, M.,Large, T.H. (deposition date: 2013-02-15, release date: 2013-05-15, Last modification date: 2023-12-20)
Primary citation	Hopkins, S.C.,Heffernan, M.L.R.,Saraswat, L.D.,Bowen, C.A.,Melnick, L.,Hardy, L.W.,Orsini, M.A.,Allen, M.S.,Koch, P.,Spear, K.L.,Foglesong, R.J.,Soukri, M.,Chytil, M.,Fang, Q.K.,Jones, S.W.,Varney, M.A.,Panatier, A.,Oliet, S.H.R.,Pollegioni, L.,Piubelli, L.,Molla, G.,Nardini, M.,Large, T.H. Structural, Kinetic, and Pharmacodynamic Mechanisms of D-Amino Acid Oxidase Inhibition by Small Molecules. J.Med.Chem., 56:3710-, 2013 Cited by PubMed: 23631755 DOI: 10.1021/JM4002583 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation