3ZNP

IN VITRO AND IN VIVO INHIBITION OF HUMAN D-AMINO ACID OXIDASE: REGULATION OF D-SERINE CONCENTRATION IN THE BRAIN

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	SYNCHROTRON
Source details	ALS
Synchrotron site	ALS
Temperature [K]	100
Spacegroup name	P 32 2 1
Unit cell lengths	84.069, 84.069, 189.163
Unit cell angles	90.00, 90.00, 120.00

Refinement procedure

Resolution	34.980 - 2.400
R-factor	0.2356
Rwork	0.232
R-free	0.30670
Structure solution method	MOLECULAR REPLACEMENT
Starting model (for MR)	2du8
RMSD bond length	0.010
RMSD bond angle	1.170
Data reduction software	d*TREK
Phasing software	MOLREP
Refinement software	BUSTER (2.11.1)

Data quality characteristics

	Overall	Outer shell
Low resolution limit [Å]	47.660	2.490
High resolution limit [Å]	2.400	2.400
Rmerge	0.080	0.460
Number of reflections	30588
<I/σ(I)>	7.7	1.9
Completeness [%]	98.5	99.5
Redundancy	3.27	3.27

Crystallization Conditions

crystal ID	method	pH	temperature	details
1