3ZNP
IN VITRO AND IN VIVO INHIBITION OF HUMAN D-AMINO ACID OXIDASE: REGULATION OF D-SERINE CONCENTRATION IN THE BRAIN
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003884 | molecular_function | D-amino-acid oxidase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005576 | cellular_component | extracellular region |
A | 0005737 | cellular_component | cytoplasm |
A | 0005741 | cellular_component | mitochondrial outer membrane |
A | 0005777 | cellular_component | peroxisome |
A | 0005782 | cellular_component | peroxisomal matrix |
A | 0005829 | cellular_component | cytosol |
A | 0006562 | biological_process | proline catabolic process |
A | 0007586 | biological_process | digestion |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0019478 | biological_process | D-amino acid catabolic process |
A | 0036088 | biological_process | D-serine catabolic process |
A | 0042416 | biological_process | dopamine biosynthetic process |
A | 0042802 | molecular_function | identical protein binding |
A | 0042995 | cellular_component | cell projection |
A | 0045202 | cellular_component | synapse |
A | 0046416 | biological_process | D-amino acid metabolic process |
A | 0048786 | cellular_component | presynaptic active zone |
A | 0055130 | biological_process | D-alanine catabolic process |
A | 0070178 | biological_process | D-serine metabolic process |
A | 0070945 | biological_process | neutrophil-mediated killing of gram-negative bacterium |
A | 0071949 | molecular_function | FAD binding |
B | 0003884 | molecular_function | D-amino-acid oxidase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005576 | cellular_component | extracellular region |
B | 0005737 | cellular_component | cytoplasm |
B | 0005741 | cellular_component | mitochondrial outer membrane |
B | 0005777 | cellular_component | peroxisome |
B | 0005782 | cellular_component | peroxisomal matrix |
B | 0005829 | cellular_component | cytosol |
B | 0006562 | biological_process | proline catabolic process |
B | 0007586 | biological_process | digestion |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0019478 | biological_process | D-amino acid catabolic process |
B | 0036088 | biological_process | D-serine catabolic process |
B | 0042416 | biological_process | dopamine biosynthetic process |
B | 0042802 | molecular_function | identical protein binding |
B | 0042995 | cellular_component | cell projection |
B | 0045202 | cellular_component | synapse |
B | 0046416 | biological_process | D-amino acid metabolic process |
B | 0048786 | cellular_component | presynaptic active zone |
B | 0055130 | biological_process | D-alanine catabolic process |
B | 0070178 | biological_process | D-serine metabolic process |
B | 0070945 | biological_process | neutrophil-mediated killing of gram-negative bacterium |
B | 0071949 | molecular_function | FAD binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 33 |
Details | BINDING SITE FOR RESIDUE FAD A 350 |
Chain | Residue |
A | ILE6 |
A | THR43 |
A | THR44 |
A | THR45 |
A | ALA48 |
A | GLY50 |
A | LEU51 |
A | ARG162 |
A | VAL164 |
A | CYS181 |
A | THR182 |
A | GLY7 |
A | GLY183 |
A | TRP185 |
A | GLY281 |
A | ARG283 |
A | GLY312 |
A | GLY313 |
A | TYR314 |
A | GLY315 |
A | LEU316 |
A | THR317 |
A | ALA8 |
A | SE2360 |
A | HOH2018 |
A | HOH2021 |
A | HOH2060 |
A | GLY9 |
A | VAL10 |
A | ILE11 |
A | ALA36 |
A | ASP37 |
A | ARG38 |
site_id | AC2 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE SE2 A 360 |
Chain | Residue |
A | LEU51 |
A | LEU215 |
A | TYR224 |
A | TYR228 |
A | ILE230 |
A | ARG283 |
A | GLY313 |
A | FAD350 |
site_id | AC3 |
Number of Residues | 33 |
Details | BINDING SITE FOR RESIDUE FAD B 350 |
Chain | Residue |
B | GLY7 |
B | ALA8 |
B | GLY9 |
B | VAL10 |
B | ILE11 |
B | ALA36 |
B | ASP37 |
B | ARG38 |
B | THR43 |
B | THR44 |
B | THR45 |
B | ALA48 |
B | ALA49 |
B | GLY50 |
B | LEU51 |
B | ARG162 |
B | LYS163 |
B | VAL164 |
B | CYS181 |
B | THR182 |
B | GLY183 |
B | TRP185 |
B | ILE202 |
B | GLY281 |
B | ARG283 |
B | PRO284 |
B | GLY312 |
B | GLY313 |
B | TYR314 |
B | GLY315 |
B | LEU316 |
B | THR317 |
B | HOH2015 |
site_id | AC4 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE GOL B 1341 |
Chain | Residue |
B | SER25 |
B | VAL26 |
site_id | AC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL A 1341 |
Chain | Residue |
A | ASP31 |
A | GLY156 |
A | LYS158 |
site_id | AC6 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE GOL A 1342 |
Chain | Residue |
A | GLU292 |
A | ARG293 |
site_id | AC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE GOL B 1342 |
Chain | Residue |
A | ASN143 |
B | ARG274 |
B | ILE275 |
B | ILE276 |
site_id | AC8 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE GOL B 1343 |
Chain | Residue |
B | GLN243 |
B | LEU244 |
site_id | AC9 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE GOL A 1343 |
Chain | Residue |
A | GLU154 |
site_id | BC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GOL A 1344 |
Chain | Residue |
A | LEU56 |
A | HIS217 |
A | ASP218 |
A | PRO219 |
A | ILE223 |
A | HOH2034 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 14 |
Details | BINDING: BINDING => ECO:0000269|PubMed:17088322, ECO:0000269|PubMed:18455394 |
Chain | Residue | Details |
B | ALA49 | |
B | VAL164 | |
B | THR182 | |
B | GLY312 | |
A | VAL3 | |
A | ASP37 | |
A | THR44 | |
A | ALA49 | |
A | VAL164 | |
A | THR182 | |
A | GLY312 | |
B | VAL3 | |
B | ASP37 | |
B | THR44 |
site_id | SWS_FT_FI2 |
Number of Residues | 10 |
Details | BINDING: |
Chain | Residue | Details |
B | ARG283 | |
B | GLY313 | |
A | GLN53 | |
A | HIS217 | |
A | TYR228 | |
A | ARG283 | |
A | GLY313 | |
B | GLN53 | |
B | HIS217 | |
B | TYR228 |