7A2H
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![BU of 7a2h by Molmil](/molmil-images/mine/7a2h) | Crystal structure of human protein kinase CK2alpha' (CSNK2A2 gene product) in complex with the ATP-competitive inhibitor 5,6,7-tribromo-1H-imidazo[4,5-b]pyridine | Descriptor: | 1,2-ETHANEDIOL, 5,6,7-tris(bromanyl)-1~{H}-imidazo[4,5-b]pyridine, Casein kinase II subunit alpha' | Authors: | Niefind, K, Lindenblatt, D, Toelzer, C, Bretner, M, Chojnacki, K, Wielechowska, M, Winska, P. | Deposit date: | 2020-08-18 | Release date: | 2020-12-09 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.01 Å) | Cite: | Synthesis, biological properties and structural study of new halogenated azolo[4,5-b]pyridines as inhibitors of CK2 kinase. Bioorg.Chem., 106, 2021
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7A4C
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![BU of 7a4c by Molmil](/molmil-images/mine/7a4c) | Crystal structure of human protein kinase CK2alpha (CSNK2A1 gene product) in complex with the ATP-competitive inhibitor 5,6,7-tribromo-1H-triazolo[4,5-b]pyridine | Descriptor: | 5,6,7-tris(bromanyl)-1~{H}-[1,2,3]triazolo[4,5-b]pyridine, Casein kinase II subunit alpha, GLYCEROL, ... | Authors: | Niefind, K, Lindenblatt, D, Toelzer, C, Bretner, M, Chojnacki, K, Wielechowska, M, Winska, P. | Deposit date: | 2020-08-19 | Release date: | 2020-12-09 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.502 Å) | Cite: | Synthesis, biological properties and structural study of new halogenated azolo[4,5-b]pyridines as inhibitors of CK2 kinase. Bioorg.Chem., 106, 2021
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3M56
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![BU of 3m56 by Molmil](/molmil-images/mine/3m56) | SET7/9 Y305F in complex with TAF10-K189me2 peptide and AdoHcy | Descriptor: | Histone-lysine N-methyltransferase SETD7, S-ADENOSYL-L-HOMOCYSTEINE, TAF10-K189me2 PEPTIDE | Authors: | Del Rizzo, P.A, Couture, J.-F, Roiko, M.S, Strunk, B.S, Brunzelle, J.S, Dirk, L.M, Houtz, R.L, Trievel, R.C. | Deposit date: | 2010-03-12 | Release date: | 2010-07-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | SET7/9 catalytic mutants reveal the role of active site water molecules in lysine multiple methylation. J.Biol.Chem., 285, 2010
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6ZLW
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![BU of 6zlw by Molmil](/molmil-images/mine/6zlw) | SARS-CoV-2 Nsp1 bound to the human 40S ribosomal subunit | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | Authors: | Thoms, M, Buschauer, R, Ameismeier, M, Denk, T, Kratzat, H, Mackens-Kiani, T, Cheng, J, Berninghausen, O, Becker, T, Beckmann, R. | Deposit date: | 2020-07-01 | Release date: | 2020-07-29 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2. Science, 369, 2020
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6IM0
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![BU of 6im0 by Molmil](/molmil-images/mine/6im0) | Crystal structure of a highly thermostable carbonic anhydrase from Persephonella marina EX-H1 | Descriptor: | BICARBONATE ION, CALCIUM ION, Carbonic anhydrase (Carbonate dehydratase), ... | Authors: | Jin, M.S, Kim, S, Sung, J, Yeon, J, Choi, S.H. | Deposit date: | 2018-10-21 | Release date: | 2019-07-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal Structure of a Highly Thermostable alpha-Carbonic Anhydrase from Persephonella marina EX-H1. Mol.Cells, 42, 2019
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6IN5
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![BU of 6in5 by Molmil](/molmil-images/mine/6in5) | |
6I4R
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![BU of 6i4r by Molmil](/molmil-images/mine/6i4r) | Crystal structure of the disease-causing R460G mutant of the human dihydrolipoamide dehydrogenase at 1.44 Angstrom resolution | Descriptor: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Dihydrolipoyl dehydrogenase, mitochondrial, ... | Authors: | Szabo, E, Wilk, P, Bui, D, Torocsik, B, Weiss, M.S, Adam-Vizi, V, Ambrus, A. | Deposit date: | 2018-11-10 | Release date: | 2019-11-20 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.439 Å) | Cite: | Underlying molecular alterations in human dihydrolipoamide dehydrogenase deficiency revealed by structural analyses of disease-causing enzyme variants. Hum.Mol.Genet., 28, 2019
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6R4V
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![BU of 6r4v by Molmil](/molmil-images/mine/6r4v) | Crystal structure of human geranylgeranyl diphosphate synthase bound to ibandronate | Descriptor: | GLYCEROL, Geranylgeranyl pyrophosphate synthase, IBANDRONATE, ... | Authors: | Lisnyansky, M, Giladi, M, Haitin, Y. | Deposit date: | 2019-03-24 | Release date: | 2019-09-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.202 Å) | Cite: | Metal Coordination Is Crucial for Geranylgeranyl Diphosphate Synthase-Bisphosphonate Interactions: A Crystallographic and Computational Analysis. Mol.Pharmacol., 96, 2019
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8OY0
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![BU of 8oy0 by Molmil](/molmil-images/mine/8oy0) | ATP phosphoribosyltransferase (HisZG ATPPRT) from Acinetobacter baumanii | Descriptor: | ATP phosphoribosyltransferase, ATP phosphoribosyltransferase regulatory subunit, GLYCEROL, ... | Authors: | Alphey, M.S, Read, B, da Silva, R.G. | Deposit date: | 2023-05-03 | Release date: | 2023-11-29 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal Structure, Steady-State, and Pre-Steady-State Kinetics of Acinetobacter baumannii ATP Phosphoribosyltransferase. Biochemistry, 63, 2024
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3KJQ
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![BU of 3kjq by Molmil](/molmil-images/mine/3kjq) | Caspase 8 with covalent inhibitor | Descriptor: | (3S)-3-({[(5S,8R)-2-(3-carboxypropyl)-8-(2-{[(4-chlorophenyl)acetyl]amino}ethyl)-1,3-dioxo-2,3,5,8-tetrahydro-1H-[1,2,4]triazolo[1,2-a]pyridazin-5-yl]carbonyl}amino)-4-oxopentanoic acid, Caspase-8 | Authors: | Kamtekar, S, Watt, W, Finzel, B.C, Harris, M.S, Blinn, J, Wang, Z, Tomasselli, A.G. | Deposit date: | 2009-11-03 | Release date: | 2010-08-11 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Kinetic and structural characterization of caspase-3 and caspase-8 inhibition by a novel class of irreversible inhibitors. Biochim.Biophys.Acta, 1804, 2010
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7X91
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![BU of 7x91 by Molmil](/molmil-images/mine/7x91) | |
7X8Z
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![BU of 7x8z by Molmil](/molmil-images/mine/7x8z) | |
7X8W
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![BU of 7x8w by Molmil](/molmil-images/mine/7x8w) | |
7X8Y
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![BU of 7x8y by Molmil](/molmil-images/mine/7x8y) | |
7X90
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![BU of 7x90 by Molmil](/molmil-images/mine/7x90) | |
8J26
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![BU of 8j26 by Molmil](/molmil-images/mine/8j26) | CryoEM structure of SARS CoV-2 RBD and Aptamer complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, AM032-4, AM047-6, ... | Authors: | Rahman, M.S, Jang, S.K, Lee, J.O. | Deposit date: | 2023-04-14 | Release date: | 2023-06-21 | Last modified: | 2023-07-12 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure-Guided Development of Bivalent Aptamers Blocking SARS-CoV-2 Infection. Molecules, 28, 2023
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6I4T
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![BU of 6i4t by Molmil](/molmil-images/mine/6i4t) | Crystal structure of the disease-causing I445M mutant of the human dihydrolipoamide dehydrogenase | Descriptor: | Dihydrolipoyl dehydrogenase, mitochondrial, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Szabo, E, Wilk, P, Zambo, Z, Torocsik, B, Weiss, M.S, Adam-Vizi, V, Ambrus, A. | Deposit date: | 2018-11-10 | Release date: | 2019-11-20 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.823 Å) | Cite: | Underlying molecular alterations in human dihydrolipoamide dehydrogenase deficiency revealed by structural analyses of disease-causing enzyme variants. Hum.Mol.Genet., 28, 2019
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6I4S
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![BU of 6i4s by Molmil](/molmil-images/mine/6i4s) | Crystal structure of the disease-causing R447G mutant of the human dihydrolipoamide dehydrogenase | Descriptor: | Dihydrolipoyl dehydrogenase, mitochondrial, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Szabo, E, Wilk, P, Hubert, A, Torocsik, B, Weiss, M.S, Adam-Vizi, V, Ambrus, A. | Deposit date: | 2018-11-10 | Release date: | 2019-11-20 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Underlying molecular alterations in human dihydrolipoamide dehydrogenase deficiency revealed by structural analyses of disease-causing enzyme variants. Hum.Mol.Genet., 28, 2019
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7X92
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6AHU
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![BU of 6ahu by Molmil](/molmil-images/mine/6ahu) | Cryo-EM structure of human Ribonuclease P with mature tRNA | Descriptor: | H1 RNA, Ribonuclease P protein subunit p14, Ribonuclease P protein subunit p20, ... | Authors: | Wu, J, Niu, S, Tan, M, Lan, P, Lei, M. | Deposit date: | 2018-08-20 | Release date: | 2018-12-05 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.66 Å) | Cite: | Cryo-EM Structure of the Human Ribonuclease P Holoenzyme. Cell, 175, 2018
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8J1Q
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![BU of 8j1q by Molmil](/molmil-images/mine/8j1q) | CryoEM structure of SARS CoV-2 RBD and Aptamer complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, AM032-0, AM047-0, ... | Authors: | Rahman, M.S, Jang, S.K, Lee, J.O. | Deposit date: | 2023-04-13 | Release date: | 2023-06-21 | Last modified: | 2023-07-12 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structure-Guided Development of Bivalent Aptamers Blocking SARS-CoV-2 Infection. Molecules, 28, 2023
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7U9C
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![BU of 7u9c by Molmil](/molmil-images/mine/7u9c) | Crystal Structure of the wild type Escherichia coli Pyridoxal 5'-phosphate homeostasis protein (YGGS) | Descriptor: | PHOSPHATE ION, PYRIDOXAL-5'-PHOSPHATE, Pyridoxal phosphate homeostasis protein | Authors: | Donkor, A.K, Ghatge, M.S, Safo, M.K, Musayev, F.N. | Deposit date: | 2022-03-10 | Release date: | 2022-03-23 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Characterization of the Escherichia coli pyridoxal 5'-phosphate homeostasis protein (YggS): Role of lysine residues in PLP binding and protein stability. Protein Sci., 31, 2022
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6KF3
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![BU of 6kf3 by Molmil](/molmil-images/mine/6kf3) | Cryo-EM structure of Thermococcus kodakarensis RNA polymerase | Descriptor: | DNA-directed RNA polymerase subunit, DNA-directed RNA polymerase subunit A'', DNA-directed RNA polymerase subunit D, ... | Authors: | Jun, S.-H, Hyun, J, Jeong, H, Cha, J.S, Kim, H, Bartlett, M.S, Cho, H.-S, Murakami, K.S. | Deposit date: | 2019-07-06 | Release date: | 2020-07-01 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Direct binding of TFE alpha opens DNA binding cleft of RNA polymerase. Nat Commun, 11, 2020
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7U9H
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![BU of 7u9h by Molmil](/molmil-images/mine/7u9h) | Crystal Structure of Escherichia coli apo Pyridoxal 5'-phosphate homeostasis protein (YGGS) | Descriptor: | Pyridoxal phosphate homeostasis protein, SULFATE ION | Authors: | Donkor, A.K, Ghatge, M.S, Musayev, F.N, Safo, M.K. | Deposit date: | 2022-03-10 | Release date: | 2022-03-23 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Characterization of the Escherichia coli pyridoxal 5'-phosphate homeostasis protein (YggS): Role of lysine residues in PLP binding and protein stability. Protein Sci., 31, 2022
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8P9O
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![BU of 8p9o by Molmil](/molmil-images/mine/8p9o) | PCNA from Chaetomium thermophilum in complex with PolD3 peptide | Descriptor: | Proliferating cell nuclear antigen, Synthetic peptide corresponding to amino acids 437 to 451 of PolD3 from Chaetomium thermophilum | Authors: | Alphey, M.S, Wolford, C.B, MacNeill, S.A. | Deposit date: | 2023-06-06 | Release date: | 2023-12-13 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Canonical binding of Chaetomium thermophilum DNA polymerase delta / zeta subunit PolD3 and flap endonuclease Fen1 to PCNA. Front Mol Biosci, 10, 2023
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