6R4V

Crystal structure of human geranylgeranyl diphosphate synthase bound to ibandronate

Summary for 6R4V

Entry DOI	10.2210/pdb6r4v/pdb
Descriptor	Geranylgeranyl pyrophosphate synthase, MAGNESIUM ION, IBANDRONATE, ... (5 entities in total)
Functional Keywords	bisphosphonate, ibandronate, geranylgeranyl diphosphate, prenyltransferase, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	6
Total formula weight	215130.43
Authors	Lisnyansky, M.,Giladi, M.,Haitin, Y. (deposition date: 2019-03-24, release date: 2019-09-18, Last modification date: 2024-01-24)
Primary citation	Lisnyansky, M.,Yariv, E.,Segal, O.,Marom, M.,Loewenstein, A.,Ben-Tal, N.,Giladi, M.,Haitin, Y. Metal Coordination Is Crucial for Geranylgeranyl Diphosphate Synthase-Bisphosphonate Interactions: A Crystallographic and Computational Analysis. Mol.Pharmacol., 96:580-588, 2019 Cited by PubMed: 31427399 DOI: 10.1124/mol.119.117499 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.202 Å)

Structure validation