6R4V

Crystal structure of human geranylgeranyl diphosphate synthase bound to ibandronate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, F, E, B...	Geranylgeranyl pyrophosphate synthase	polymer	307	35436.3	6	UniProt (O95749) Pfam (PF00348) In PDB	Homo sapiens (Human)	GGPPSase,(2E,6E)-farnesyl diphosphate synthase,Dimethylallyltranstransferase,Farnesyl diphosphate synthase,Farnesyltranstransferase,Geranylgeranyl diphosphate synthase,Geranyltranstransferase
2	D, A, C, F, E...	MAGNESIUM ION	non-polymer		24.3	17	Chemie (MG)
3	B, D, A, C, F...	IBANDRONATE	non-polymer		319.2	6	Chemie (BFQ)
4	A, C	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
5		water	water		18.0	1242	Chemie (HOH)

Sequence modifications

A, C, F, E, B, D: 1 - 300 (UniProt: O95749)

PDB	External Database	Details
Gly -6	-	expression tag
Ser -5	-	expression tag
Gly -4	-	expression tag
Ser -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
Gly 0	-	expression tag
Gln 109	Pro 109	variant

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	212617.7
Non-Polymers*	Number of molecules	25
	Total formula weight	2512.7
All*	Total formula weight	215130.4

*Water molecules are not included.