6R4V
Crystal structure of human geranylgeranyl diphosphate synthase bound to ibandronate
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004161 | molecular_function | dimethylallyltranstransferase activity |
A | 0004311 | molecular_function | farnesyltranstransferase activity |
A | 0004337 | molecular_function | geranyltranstransferase activity |
A | 0004659 | molecular_function | prenyltransferase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006720 | biological_process | isoprenoid metabolic process |
A | 0008299 | biological_process | isoprenoid biosynthetic process |
A | 0016740 | molecular_function | transferase activity |
A | 0030018 | cellular_component | Z disc |
A | 0033384 | biological_process | geranyl diphosphate biosynthetic process |
A | 0033386 | biological_process | geranylgeranyl diphosphate biosynthetic process |
A | 0042802 | molecular_function | identical protein binding |
A | 0045337 | biological_process | farnesyl diphosphate biosynthetic process |
A | 0046872 | molecular_function | metal ion binding |
A | 0048471 | cellular_component | perinuclear region of cytoplasm |
B | 0004161 | molecular_function | dimethylallyltranstransferase activity |
B | 0004311 | molecular_function | farnesyltranstransferase activity |
B | 0004337 | molecular_function | geranyltranstransferase activity |
B | 0004659 | molecular_function | prenyltransferase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005654 | cellular_component | nucleoplasm |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0006720 | biological_process | isoprenoid metabolic process |
B | 0008299 | biological_process | isoprenoid biosynthetic process |
B | 0016740 | molecular_function | transferase activity |
B | 0030018 | cellular_component | Z disc |
B | 0033384 | biological_process | geranyl diphosphate biosynthetic process |
B | 0033386 | biological_process | geranylgeranyl diphosphate biosynthetic process |
B | 0042802 | molecular_function | identical protein binding |
B | 0045337 | biological_process | farnesyl diphosphate biosynthetic process |
B | 0046872 | molecular_function | metal ion binding |
B | 0048471 | cellular_component | perinuclear region of cytoplasm |
C | 0004161 | molecular_function | dimethylallyltranstransferase activity |
C | 0004311 | molecular_function | farnesyltranstransferase activity |
C | 0004337 | molecular_function | geranyltranstransferase activity |
C | 0004659 | molecular_function | prenyltransferase activity |
C | 0005515 | molecular_function | protein binding |
C | 0005654 | cellular_component | nucleoplasm |
C | 0005737 | cellular_component | cytoplasm |
C | 0005829 | cellular_component | cytosol |
C | 0006720 | biological_process | isoprenoid metabolic process |
C | 0008299 | biological_process | isoprenoid biosynthetic process |
C | 0016740 | molecular_function | transferase activity |
C | 0030018 | cellular_component | Z disc |
C | 0033384 | biological_process | geranyl diphosphate biosynthetic process |
C | 0033386 | biological_process | geranylgeranyl diphosphate biosynthetic process |
C | 0042802 | molecular_function | identical protein binding |
C | 0045337 | biological_process | farnesyl diphosphate biosynthetic process |
C | 0046872 | molecular_function | metal ion binding |
C | 0048471 | cellular_component | perinuclear region of cytoplasm |
D | 0004161 | molecular_function | dimethylallyltranstransferase activity |
D | 0004311 | molecular_function | farnesyltranstransferase activity |
D | 0004337 | molecular_function | geranyltranstransferase activity |
D | 0004659 | molecular_function | prenyltransferase activity |
D | 0005515 | molecular_function | protein binding |
D | 0005654 | cellular_component | nucleoplasm |
D | 0005737 | cellular_component | cytoplasm |
D | 0005829 | cellular_component | cytosol |
D | 0006720 | biological_process | isoprenoid metabolic process |
D | 0008299 | biological_process | isoprenoid biosynthetic process |
D | 0016740 | molecular_function | transferase activity |
D | 0030018 | cellular_component | Z disc |
D | 0033384 | biological_process | geranyl diphosphate biosynthetic process |
D | 0033386 | biological_process | geranylgeranyl diphosphate biosynthetic process |
D | 0042802 | molecular_function | identical protein binding |
D | 0045337 | biological_process | farnesyl diphosphate biosynthetic process |
D | 0046872 | molecular_function | metal ion binding |
D | 0048471 | cellular_component | perinuclear region of cytoplasm |
E | 0004161 | molecular_function | dimethylallyltranstransferase activity |
E | 0004311 | molecular_function | farnesyltranstransferase activity |
E | 0004337 | molecular_function | geranyltranstransferase activity |
E | 0004659 | molecular_function | prenyltransferase activity |
E | 0005515 | molecular_function | protein binding |
E | 0005654 | cellular_component | nucleoplasm |
E | 0005737 | cellular_component | cytoplasm |
E | 0005829 | cellular_component | cytosol |
E | 0006720 | biological_process | isoprenoid metabolic process |
E | 0008299 | biological_process | isoprenoid biosynthetic process |
E | 0016740 | molecular_function | transferase activity |
E | 0030018 | cellular_component | Z disc |
E | 0033384 | biological_process | geranyl diphosphate biosynthetic process |
E | 0033386 | biological_process | geranylgeranyl diphosphate biosynthetic process |
E | 0042802 | molecular_function | identical protein binding |
E | 0045337 | biological_process | farnesyl diphosphate biosynthetic process |
E | 0046872 | molecular_function | metal ion binding |
E | 0048471 | cellular_component | perinuclear region of cytoplasm |
F | 0004161 | molecular_function | dimethylallyltranstransferase activity |
F | 0004311 | molecular_function | farnesyltranstransferase activity |
F | 0004337 | molecular_function | geranyltranstransferase activity |
F | 0004659 | molecular_function | prenyltransferase activity |
F | 0005515 | molecular_function | protein binding |
F | 0005654 | cellular_component | nucleoplasm |
F | 0005737 | cellular_component | cytoplasm |
F | 0005829 | cellular_component | cytosol |
F | 0006720 | biological_process | isoprenoid metabolic process |
F | 0008299 | biological_process | isoprenoid biosynthetic process |
F | 0016740 | molecular_function | transferase activity |
F | 0030018 | cellular_component | Z disc |
F | 0033384 | biological_process | geranyl diphosphate biosynthetic process |
F | 0033386 | biological_process | geranylgeranyl diphosphate biosynthetic process |
F | 0042802 | molecular_function | identical protein binding |
F | 0045337 | biological_process | farnesyl diphosphate biosynthetic process |
F | 0046872 | molecular_function | metal ion binding |
F | 0048471 | cellular_component | perinuclear region of cytoplasm |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | binding site for residue MG A 1301 |
Chain | Residue |
A | ASP64 |
A | ASP68 |
A | MG1303 |
A | BFQ1304 |
A | HOH1422 |
A | HOH1427 |
site_id | AC2 |
Number of Residues | 6 |
Details | binding site for residue MG A 1302 |
Chain | Residue |
A | BFQ1304 |
A | HOH1411 |
A | HOH1519 |
A | GLN185 |
A | ASP188 |
A | ASN192 |
site_id | AC3 |
Number of Residues | 7 |
Details | binding site for residue MG A 1303 |
Chain | Residue |
A | ASP64 |
A | ASP68 |
A | MG1301 |
A | BFQ1304 |
A | HOH1405 |
A | HOH1418 |
A | HOH1423 |
site_id | AC4 |
Number of Residues | 19 |
Details | binding site for residue BFQ A 1304 |
Chain | Residue |
A | SER60 |
A | ASP64 |
A | ASP68 |
A | ARG73 |
A | GLN126 |
A | LYS151 |
A | GLN185 |
A | ASP188 |
A | LYS202 |
A | LYS212 |
A | MG1301 |
A | MG1302 |
A | MG1303 |
A | HOH1405 |
A | HOH1418 |
A | HOH1422 |
A | HOH1427 |
A | HOH1519 |
A | HOH1555 |
site_id | AC5 |
Number of Residues | 4 |
Details | binding site for residue GOL A 1305 |
Chain | Residue |
A | LYS25 |
A | ARG28 |
A | HIS57 |
A | PHE184 |
site_id | AC6 |
Number of Residues | 6 |
Details | binding site for residue MG C 1301 |
Chain | Residue |
C | ASP64 |
C | ASP68 |
C | MG1302 |
C | BFQ1303 |
C | HOH1439 |
C | HOH1479 |
site_id | AC7 |
Number of Residues | 7 |
Details | binding site for residue MG C 1302 |
Chain | Residue |
C | ASP64 |
C | ASP68 |
C | MG1301 |
C | BFQ1303 |
C | HOH1419 |
C | HOH1431 |
C | HOH1467 |
site_id | AC8 |
Number of Residues | 6 |
Details | binding site for residue GOL C 1304 |
Chain | Residue |
C | GLY24 |
C | LYS25 |
C | HIS57 |
C | ARG74 |
C | PHE184 |
C | HOH1432 |
site_id | AC9 |
Number of Residues | 6 |
Details | binding site for residue MG F 1301 |
Chain | Residue |
F | ASP64 |
F | ASP68 |
F | MG1303 |
F | BFQ1304 |
F | HOH1412 |
F | HOH1413 |
site_id | AD1 |
Number of Residues | 5 |
Details | binding site for residue MG F 1302 |
Chain | Residue |
F | ASP207 |
F | LYS212 |
F | BFQ1304 |
F | HOH1430 |
F | HOH1520 |
site_id | AD2 |
Number of Residues | 7 |
Details | binding site for residue MG F 1303 |
Chain | Residue |
F | ASP64 |
F | ASP68 |
F | MG1301 |
F | BFQ1304 |
F | HOH1417 |
F | HOH1429 |
F | HOH1460 |
site_id | AD3 |
Number of Residues | 18 |
Details | binding site for residue BFQ F 1304 |
Chain | Residue |
F | SER60 |
F | ASP64 |
F | ASP68 |
F | ARG73 |
F | LEU122 |
F | GLN126 |
F | LYS151 |
F | GLN185 |
F | LYS202 |
F | LYS212 |
F | MG1301 |
F | MG1302 |
F | MG1303 |
F | HOH1412 |
F | HOH1413 |
F | HOH1416 |
F | HOH1429 |
F | HOH1460 |
site_id | AD4 |
Number of Residues | 7 |
Details | binding site for residue MG E 1301 |
Chain | Residue |
E | LYS202 |
E | MG1303 |
E | BFQ1304 |
E | HOH1408 |
E | HOH1463 |
E | ASP64 |
E | ASP68 |
site_id | AD5 |
Number of Residues | 5 |
Details | binding site for residue MG E 1302 |
Chain | Residue |
E | ASP188 |
E | BFQ1304 |
E | HOH1405 |
E | HOH1425 |
E | HOH1509 |
site_id | AD6 |
Number of Residues | 7 |
Details | binding site for residue MG E 1303 |
Chain | Residue |
E | ASP64 |
E | ASP68 |
E | MG1301 |
E | BFQ1304 |
E | HOH1409 |
E | HOH1462 |
E | HOH1469 |
site_id | AD7 |
Number of Residues | 16 |
Details | binding site for residue BFQ E 1304 |
Chain | Residue |
E | ASP64 |
E | ASP68 |
E | ARG73 |
E | LYS151 |
E | GLN185 |
E | ASP188 |
E | LYS202 |
E | LYS212 |
E | MG1301 |
E | MG1302 |
E | MG1303 |
E | HOH1405 |
E | HOH1409 |
E | HOH1462 |
E | HOH1463 |
E | HOH1480 |
site_id | AD8 |
Number of Residues | 6 |
Details | binding site for residue MG B 1301 |
Chain | Residue |
B | ASP64 |
B | ASP68 |
B | MG1303 |
B | BFQ1304 |
B | HOH1430 |
B | HOH1447 |
site_id | AD9 |
Number of Residues | 4 |
Details | binding site for residue MG B 1302 |
Chain | Residue |
B | ASP188 |
B | BFQ1304 |
B | HOH1416 |
B | HOH1418 |
site_id | AE1 |
Number of Residues | 7 |
Details | binding site for residue MG B 1303 |
Chain | Residue |
B | ASP64 |
B | ASP68 |
B | MG1301 |
B | BFQ1304 |
B | HOH1406 |
B | HOH1421 |
B | HOH1455 |
site_id | AE2 |
Number of Residues | 17 |
Details | binding site for residue BFQ B 1304 |
Chain | Residue |
B | SER60 |
B | ASP64 |
B | ASP68 |
B | ARG73 |
B | LEU122 |
B | GLN126 |
B | LYS151 |
B | GLN185 |
B | ASP188 |
B | LYS212 |
B | MG1301 |
B | MG1302 |
B | MG1303 |
B | HOH1406 |
B | HOH1416 |
B | HOH1430 |
B | HOH1455 |
site_id | AE3 |
Number of Residues | 6 |
Details | binding site for residue MG D 1301 |
Chain | Residue |
D | ASP64 |
D | ASP68 |
D | MG1303 |
D | BFQ1304 |
D | HOH1443 |
D | HOH1455 |
site_id | AE4 |
Number of Residues | 5 |
Details | binding site for residue MG D 1302 |
Chain | Residue |
D | ASP188 |
D | BFQ1304 |
D | HOH1406 |
D | HOH1423 |
D | HOH1434 |
site_id | AE5 |
Number of Residues | 7 |
Details | binding site for residue MG D 1303 |
Chain | Residue |
D | ASP64 |
D | ASP68 |
D | MG1301 |
D | BFQ1304 |
D | HOH1403 |
D | HOH1414 |
D | HOH1450 |
site_id | AE6 |
Number of Residues | 18 |
Details | binding site for residue BFQ D 1304 |
Chain | Residue |
D | SER60 |
D | ASP64 |
D | ASP68 |
D | ARG73 |
D | GLN126 |
D | LYS151 |
D | GLN185 |
D | ASP188 |
D | LYS212 |
D | MG1301 |
D | MG1302 |
D | MG1303 |
D | HOH1403 |
D | HOH1434 |
D | HOH1443 |
D | HOH1450 |
D | HOH1455 |
D | HOH1495 |
site_id | AE7 |
Number of Residues | 24 |
Details | binding site for Di-peptide BFQ C 1303 and LYS C 151 |
Chain | Residue |
C | SER60 |
C | ASP64 |
C | ASP68 |
C | ARG73 |
C | LEU122 |
C | GLN126 |
C | ASP129 |
C | MET147 |
C | VAL148 |
C | LEU149 |
C | GLN150 |
C | THR152 |
C | GLN185 |
C | ASP188 |
C | LYS202 |
C | LYS212 |
C | MG1301 |
C | MG1302 |
C | HOH1403 |
C | HOH1408 |
C | HOH1426 |
C | HOH1431 |
C | HOH1439 |
C | HOH1467 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 18 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:P14324 |
Chain | Residue | Details |
A | LYS25 | |
E | LYS25 | |
E | ARG28 | |
E | ARG74 | |
B | LYS25 | |
B | ARG28 | |
B | ARG74 | |
D | LYS25 | |
D | ARG28 | |
D | ARG74 | |
A | ARG28 | |
A | ARG74 | |
C | LYS25 | |
C | ARG28 | |
C | ARG74 | |
F | LYS25 | |
F | ARG28 | |
F | ARG74 |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q12051 |
Chain | Residue | Details |
A | HIS57 | |
C | HIS57 | |
F | HIS57 | |
E | HIS57 | |
B | HIS57 | |
D | HIS57 |
site_id | SWS_FT_FI3 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:16698791 |
Chain | Residue | Details |
A | ASP64 | |
B | ASP68 | |
D | ASP64 | |
D | ASP68 | |
A | ASP68 | |
C | ASP64 | |
C | ASP68 | |
F | ASP64 | |
F | ASP68 | |
E | ASP64 | |
E | ASP68 | |
B | ASP64 |
site_id | SWS_FT_FI4 |
Number of Residues | 30 |
Details | BINDING: |
Chain | Residue | Details |
A | ARG73 | |
C | LYS202 | |
F | ARG73 | |
F | LYS151 | |
F | THR152 | |
F | GLN185 | |
F | LYS202 | |
E | ARG73 | |
E | LYS151 | |
E | THR152 | |
E | GLN185 | |
A | LYS151 | |
E | LYS202 | |
B | ARG73 | |
B | LYS151 | |
B | THR152 | |
B | GLN185 | |
B | LYS202 | |
D | ARG73 | |
D | LYS151 | |
D | THR152 | |
D | GLN185 | |
A | THR152 | |
D | LYS202 | |
A | GLN185 | |
A | LYS202 | |
C | ARG73 | |
C | LYS151 | |
C | THR152 | |
C | GLN185 |
site_id | SWS_FT_FI5 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | LYS212 | |
C | LYS212 | |
F | LYS212 | |
E | LYS212 | |
B | LYS212 | |
D | LYS212 |
site_id | SWS_FT_FI6 |
Number of Residues | 6 |
Details | MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22814378 |
Chain | Residue | Details |
A | MET1 | |
C | MET1 | |
F | MET1 | |
E | MET1 | |
B | MET1 | |
D | MET1 |