SARS-CoV-2 Nsp1 bound to the human 40S ribosomal subunit

Summary for 6ZLW

EMDB information11276
Descriptor40S ribosomal protein SA, 40S ribosomal protein S3a, 40S ribosomal protein S2, ... (37 entities in total)
Functional Keywordstranslational inhibition, sars-cov-2, immune evasion, human ribosome, viral protein
Biological sourceSevere acute respiratory syndrome coronavirus 2 (2019-nCoV)
Total number of polymer chains36
Total molecular weight1245111.62
Primary citation
Thoms, M.,Buschauer, R.,Ameismeier, M.,Koepke, L.,Denk, T.,Hirschenberger, M.,Kratzat, H.,Hayn, M.,Mackens-Kiani, T.,Cheng, J.,Straub, J.H.,Sturzel, C.M.,Frohlich, T.,Berninghausen, O.,Becker, T.,Kirchhoff, F.,Sparrer, K.M.J.,Beckmann, R.
Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.
Science, 2020
PubMed: 32680882 (PDB entries with the same primary citation)
DOI: 10.1126/science.abc8665
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliersRNA backbone4 0.2% 0.9% 0.49MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures
Download full validation reportDownload
PDB entries from 2020-08-12