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PDB: 51689 件

6HIY
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Cryo-EM structure of the Trypanosoma brucei mitochondrial ribosome - This entry contains the body of the small mitoribosomal subunit in complex with mt-IF-3
分子名称: 9S rRNA, MAGNESIUM ION, SPERMIDINE, ...
著者Ramrath, D.J.F, Niemann, M, Leibundgut, M, Bieri, P, Prange, C, Horn, E.K, Leitner, A, Boehringer, D, Schneider, A, Ban, N.
登録日2018-08-31
公開日2018-09-26
最終更新日2019-12-11
実験手法ELECTRON MICROSCOPY (3.27 Å)
主引用文献Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes.
Science, 362, 2018
1AFS
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RECOMBINANT RAT LIVER 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE (3-ALPHA-HSD) COMPLEXED WITH NADP AND TESTOSTERONE
分子名称: 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, TESTOSTERONE
著者Bennett, M.J, Albert, R.H, Jez, J.M, Ma, H, Penning, T.M, Lewis, M.
登録日1997-03-13
公開日1997-10-08
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Steroid recognition and regulation of hormone action: crystal structure of testosterone and NADP+ bound to 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase.
Structure, 5, 1997
3MGY
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BU of 3mgy by Molmil
Mutagenesis of p38 MAP Kinase eshtablishes key roles of Phe169 in function and structural dynamics and reveals a novel DFG-out state
分子名称: Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside
著者Namboodiri, H.V, Karpusas, M, Bukhtiyarova, M, Springman, E.B.
登録日2010-04-07
公開日2010-04-21
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Mutagenesis of p38alpha MAP kinase establishes key roles of Phe169 in function and structural dynamics and reveals a novel DFG-OUT state.
Biochemistry, 46, 2007
6Z4E
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The structure of the C-terminal domain of RssB from E. coli
分子名称: Regulator of RpoS
著者Zeth, K, Dimce, M, Terrence, D.M, Schuenemann, V, Dougan, D.
登録日2020-05-25
公開日2020-07-29
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Insight into the RssB-Mediated Recognition and Delivery of sigma s to the AAA+ Protease, ClpXP.
Biomolecules, 10, 2020
5CGD
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Structure of the human class C GPCR metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator 3-chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile - (HTL14242)
分子名称: 3-chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile, Metabotropic glutamate receptor 5,Endolysin,Metabotropic glutamate receptor 5, OLEIC ACID
著者Christopher, J.A, Aves, S.J, Bennett, K.A, Dore, A.S, Errey, J.C, Jazayeri, A, Marshall, F.H, Okrasa, K, Serrano-Vega, M.J, Tehan, B.G, Wiggin, G.R, Congreve, M.
登録日2015-07-09
公開日2015-08-12
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.603 Å)
主引用文献Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile).
J.Med.Chem., 58, 2015
5MLM
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Plantago Major multifunctional oxidoreductase V150M mutant in complex with progesterone and NADP+
分子名称: NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PROGESTERONE, Progesterone 5-beta-reductase
著者Fellows, R, Russo, C.M, Lee, S.G, Jez, J.M, Chisholm, J.D, Zubieta, C, Nanao, M.
登録日2016-12-07
公開日2018-08-01
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.563 Å)
主引用文献A multisubstrate reductase from Plantago major: structure-function in the short chain reductase superfamily.
Sci Rep, 8, 2018
5CD8
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BU of 5cd8 by Molmil
Crystal structure of the NTD of Drosophila Oskar protein
分子名称: GLYCEROL, Maternal effect protein oskar
著者Yang, N, Hu, M, Yu, Z, Wang, M, Lehmann, R, Xu, R.M.
登録日2015-07-03
公開日2015-09-02
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (3.001 Å)
主引用文献Structure of Drosophila Oskar reveals a novel RNA binding protein
Proc.Natl.Acad.Sci.USA, 112, 2015
1X7X
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BU of 1x7x by Molmil
Crystal structure of the human mitochondrial branched-chain alpha-ketoacid dehydrogenase
分子名称: 2-oxoisovalerate dehydrogenase alpha subunit, 2-oxoisovalerate dehydrogenase beta subunit, CHLORIDE ION, ...
著者Wynn, R.M, Kato, M, Machius, M, Chuang, J.L, Li, J, Tomchick, D.R, Chuang, D.T.
登録日2004-08-16
公開日2004-11-23
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Molecular mechanism for regulation of the human mitochondrial branched-chain alpha-ketoacid dehydrogenase complex by phosphorylation
Structure, 12, 2004
8GPM
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BU of 8gpm by Molmil
Acinetobacter baumannii carbonic anhydrase
分子名称: CALCIUM ION, Carbonic anhydrase, GLYCEROL, ...
著者Wen, Y, Jiao, M.
登録日2022-08-26
公開日2023-05-31
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Acinetobacter baumannii carbonic anhydrase
Structure, 2023
7ZPF
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BU of 7zpf by Molmil
Three-dimensional structure of AIP56, a short-trip single chain AB toxin from Photobacterium damselae subsp. piscicida.
分子名称: Aip56, GLYCEROL, NICKEL (II) ION, ...
著者Lisboa, J, Pereira, P.J.B, dos Santos, N.M.S.
登録日2022-04-27
公開日2023-05-10
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.54 Å)
主引用文献Unconventional structure and mechanisms for membrane interaction and translocation of the NF-kappa B-targeting toxin AIP56.
Nat Commun, 14, 2023
8A1N
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Crystal structure of the transpeptidase LdtMt2 from Mycobacterium tuberculosis in complex with fumaryl amide analogue 13
分子名称: (Z)-N-(4-chlorophenyl)-4-oxidanylidene-but-2-enamide, 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, ...
著者de Munnik, M, Lang, P.A, Brem, J, Schofield, C.J.
登録日2022-06-01
公開日2023-06-14
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献High-throughput screen with the l,d-transpeptidase Ldt Mt2 of Mycobacterium tuberculosis reveals novel classes of covalently reacting inhibitors.
Chem Sci, 14, 2023
5CGC
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Structure of the human class C GPCR metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator 3-chloro-4-fluoro-5-[6-(1H-pyrazol-1-yl)pyrimidin-4-yl]benzonitrile
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-chloro-4-fluoro-5-[6-(1H-pyrazol-1-yl)pyrimidin-4-yl]benzonitrile, Metabotropic glutamate receptor 5,Endolysin,Metabotropic glutamate receptor 5, ...
著者Christopher, J.A, Aves, S.J, Bennett, K.A, Dore, A.S, Errey, J.C, Jazayeri, A, Marshall, F.H, Okrasa, K, Serrano-Vega, M.J, Tehan, B.G, Wiggin, G.R, Congreve, M.
登録日2015-07-09
公開日2015-08-12
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.101 Å)
主引用文献Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile).
J.Med.Chem., 58, 2015
6HYY
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BU of 6hyy by Molmil
Human phosphoserine phosphatase with serine and phosphate
分子名称: CALCIUM ION, MAGNESIUM ION, PHOSPHATE ION, ...
著者Wouters, J, Haufroid, M, Mirgaux, M.
登録日2018-10-22
公開日2019-06-12
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.566 Å)
主引用文献Crystal structures and snapshots along the reaction pathway of human phosphoserine phosphatase.
Acta Crystallogr D Struct Biol, 75, 2019
8A1M
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Crystal structure of the transpeptidase LdtMt2 from Mycobacterium tuberculosis in complex with maleimide analogue 4
分子名称: 1,2-ETHANEDIOL, 1-(2-fluoranyl-5-methylsulfonyl-phenyl)pyrrolidine-2,5-dione, CHLORIDE ION, ...
著者de Munnik, M, Lang, P.A, Brem, J, Schofield, C.J.
登録日2022-06-01
公開日2023-06-14
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献High-throughput screen with the l,d-transpeptidase Ldt Mt2 of Mycobacterium tuberculosis reveals novel classes of covalently reacting inhibitors.
Chem Sci, 14, 2023
8A1K
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Crystal structure of the transpeptidase LdtMt2 from Mycobacterium tuberculosis in complex with ebsulfur analogue 15
分子名称: 1,2-ETHANEDIOL, 4,5-bis(chloranyl)-N-(2-hydroxyethyl)-2-sulfanyl-benzamide, DIMETHYL SULFOXIDE, ...
著者de Munnik, M, Lang, P.A, Brem, J, Schofield, C.J.
登録日2022-06-01
公開日2023-06-14
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献High-throughput screen with the l,d-transpeptidase Ldt Mt2 of Mycobacterium tuberculosis reveals novel classes of covalently reacting inhibitors.
Chem Sci, 14, 2023
1XIM
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BU of 1xim by Molmil
ARGININE RESIDUES AS STABILIZING ELEMENTS IN PROTEINS
分子名称: COBALT (II) ION, D-XYLOSE ISOMERASE, Xylitol
著者Mrabet, N.T, Van Denbroek, A, Van Den Brande, I, Stanssens, P, Laroche, Y, Lambeir, A.-M, Matthyssens, G, Jenkins, J, Chiadmi, M, Vantilbeurgh, H, Rey, F, Janin, J, Quax, W.J, Lasters, I, Demaeyer, M, Wodak, S.J.
登録日1991-05-29
公開日1993-04-15
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Arginine residues as stabilizing elements in proteins.
Biochemistry, 31, 1992
1SY9
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BU of 1sy9 by Molmil
Structure of calmodulin complexed with a fragment of the olfactory CNG channel
分子名称: CALCIUM ION, CALMODULIN, Cyclic-nucleotide-gated olfactory channel
著者Contessa, G.M, Orsale, M, Melino, S, Torre, V, Paci, M, Desideri, A, Cicero, D.O.
登録日2004-04-01
公開日2005-04-12
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Structure of calmodulin complexed with an olfactory CNG channel fragment and role of the central linker: residual dipolar couplings to evaluate calmodulin binding modes outside the kinase family.
J.Biomol.Nmr, 31, 2005
8A1O
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Crystal structure of the transpeptidase LdtMt2 from Mycobacterium tuberculosis in complex with acrylamide analogue 8
分子名称: (E)-3-chloranyl-3-[(2-chlorophenyl)methylsulfonyl]-N-(5-methoxypyridin-2-yl)prop-2-enamide, 1,2-ETHANEDIOL, CHLORIDE ION, ...
著者de Munnik, M, Lang, P.A, Brem, J, Schofield, C.J.
登録日2022-06-01
公開日2023-06-14
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献High-throughput screen with the l,d-transpeptidase Ldt Mt2 of Mycobacterium tuberculosis reveals novel classes of covalently reacting inhibitors.
Chem Sci, 14, 2023
6HRE
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Paired helical filament from sporadic Alzheimer's disease brain
分子名称: Microtubule-associated protein tau
著者Falcon, B, Zhang, W, Schweighauser, M, Murzin, A.G, Vidal, R, Garringer, H.J, Ghetti, B, Scheres, S.H.W, Goedert, M.
登録日2018-09-26
公開日2018-10-10
最終更新日2024-07-10
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Tau filaments from multiple cases of sporadic and inherited Alzheimer's disease adopt a common fold.
Acta Neuropathol., 136, 2018
3MRL
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Crystal Structure of MHC class I HLA-A2 molecule complexed with HCV NS3-1073-1081 nonapeptide C6V variant
分子名称: 9-meric peptide from Serine protease/NTPase/helicase NS3, Beta-2-microglobulin, HLA class I histocompatibility antigen, ...
著者Gras, S, Reiser, J.-B, Chouquet, A, Le Gorrec, M, Debeaupuis, E, Echasserieau, K, Saulquin, X, Bonneville, M, Housset, D.
登録日2010-04-29
公開日2011-05-25
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Analysis of Relationships between Peptide/MHC Structural Features and Naive T Cell Frequency in Humans.
J.Immunol., 193, 2014
6AQJ
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Crystal structures of Staphylococcus aureus ketol-acid reductoisomerase in complex with two transition state analogs that have biocidal activity.
分子名称: 1,2-ETHANEDIOL, GLYCEROL, Ketol-acid reductoisomerase (NADP(+)), ...
著者Patel, K.M, Teran, D, Zheng, S, Gracia, M, Lv, Y, Schembri, M.A, McGeary, R.P, Schenk, G, Guddat, L.W.
登録日2017-08-20
公開日2017-10-18
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.373 Å)
主引用文献Crystal Structures of Staphylococcus aureus Ketol-Acid Reductoisomerase in Complex with Two Transition State Analogues that Have Biocidal Activity.
Chemistry, 23, 2017
6TNN
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Mini-RNase III (Mini-III) bound to 50S ribosome with precursor 23S rRNA
分子名称: 50S ribosomal protein L10, 50S ribosomal protein L13, 50S ribosomal protein L14, ...
著者Oerum, S, Dendooven, T, Gilet, L, Catala, M, Degut, C, Trinquier, A, Barraud, P, Luisi, B, Condon, C, Tisne, C.
登録日2019-12-09
公開日2020-09-30
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (3.07 Å)
主引用文献Structures of B. subtilis Maturation RNases Captured on 50S Ribosome with Pre-rRNAs.
Mol.Cell, 80, 2020
8A1L
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Crystal structure of the transpeptidase LdtMt2 from Mycobacterium tuberculosis in complex with alpha-chloro ketone 2
分子名称: (phenylmethyl) N-[(3S,4S)-4-methyl-2-oxidanylidene-hexan-3-yl]carbamate, 1,2-ETHANEDIOL, CHLORIDE ION, ...
著者de Munnik, M, Lang, P.A, Brem, J, Schofield, C.J.
登録日2022-06-01
公開日2023-06-14
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献High-throughput screen with the l,d-transpeptidase Ldt Mt2 of Mycobacterium tuberculosis reveals novel classes of covalently reacting inhibitors.
Chem Sci, 14, 2023
8A1J
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Crystal structure of the transpeptidase LdtMt2 from Mycobacterium tuberculosis in complex with maleimide analogue 3
分子名称: 1,2-ETHANEDIOL, 1-phenylpyrrolidine-2,5-dione, DIMETHYL SULFOXIDE, ...
著者de Munnik, M, Lang, P.A, Brem, J, Schofield, C.J.
登録日2022-06-01
公開日2023-06-14
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献High-throughput screen with the l,d-transpeptidase Ldt Mt2 of Mycobacterium tuberculosis reveals novel classes of covalently reacting inhibitors.
Chem Sci, 14, 2023
8A23
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Crystal structure of SARS-CoV-2 nsp10/nsp16 methyltransferase in complex with TO383
分子名称: (2R,3R,4S,5R)-2-[4-azanyl-5-(2-quinolin-3-ylethynyl)pyrrolo[2,3-d]pyrimidin-7-yl]-5-(hydroxymethyl)oxolane-3,4-diol, 2'-O-methyltransferase nsp16, GLYCEROL, ...
著者Hanigovsky, M, Krafcikova, P, Klima, M, Boura, E.
登録日2022-06-02
公開日2023-06-14
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structure of SARS-CoV-2 nsp10/nsp16 methyltransferase in complex with TO383
To Be Published

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件を2024-09-04に公開中

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