6T7Y
 
 | | Structure of PCNA bound to cPIP motif of DP2 from P. abyssi | | 分子名称: | DNA polymerase sliding clamp, cPIP motif from the DP2 large subunit of PolD | | 著者 | Madru, C, Raia, P, Hugonneau Beaufet, I, Delarue, M, Carroni, M, Sauguet, L. | | 登録日 | 2019-10-23 | | 公開日 | 2020-03-04 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural basis for the increased processivity of D-family DNA polymerases in complex with PCNA.
Nat Commun, 11, 2020
|
|
3NPY
 | | Crystal Structure of Tyrosinase from Bacillus megaterium soaked in CuSO4 | | 分子名称: | CHLORIDE ION, COPPER (II) ION, Tyrosinase, ... | | 著者 | Sendovski, M, Kanteev, M, Adir, N, Fishman, A. | | 登録日 | 2010-06-29 | | 公開日 | 2010-11-17 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.192 Å) | | 主引用文献 | First structures of an active bacterial tyrosinase reveal copper plasticity.
J.Mol.Biol., 405, 2011
|
|
4M3Q
 | | Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC1917 | | 分子名称: | CHLORIDE ION, MAGNESIUM ION, Tyrosine-protein kinase Mer, ... | | 著者 | Zhang, W, Zhang, D, Stashko, M.A, DeRyckere, D, Hunter, D, Kireev, D.B, Miley, M, Cummings, C, Lee, M, Norris-Drouin, J, Stewart, W.M, Sather, S, Zhou, Y, Kirkpatrick, G, Machius, M, Janzen, W.P, Earp, H.S, Graham, D.K, Frye, S, Wang, X. | | 登録日 | 2013-08-06 | | 公開日 | 2013-11-27 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.718 Å) | | 主引用文献 | Pseudo-Cyclization through Intramolecular Hydrogen Bond Enables Discovery of Pyridine Substituted Pyrimidines as New Mer Kinase Inhibitors.
J.Med.Chem., 56, 2013
|
|
1U3J
 | | Crystal structure of MLAV mutant of dimerisation domain of NF-kB p50 transcription factor | | 分子名称: | Nuclear factor NF-kappa-B p105 subunit | | 著者 | Chirgadze, D.Y, Demydchuk, M, Becker, M, Moran, S, Paoli, M. | | 登録日 | 2004-07-22 | | 公開日 | 2004-08-17 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.901 Å) | | 主引用文献 | Snapshot of Protein Structure Evolution Reveals Conservation of Functional Dimerization through Intertwined Folding
Structure, 12, 2004
|
|
7KCR
 | | Cryo-EM structure of Zika virus in complex with E protein cross-linking human monoclonal antibody ADI30056 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADI30056 Fab heavy chain variable region, ADI30056 Fab light chain variable region, ... | | 著者 | Sevvana, M, Rogers, T.F, Miller, A.S, Long, F, Klose, T, Beutler, N, Lai, Y.C, Parren, M, Walker, L.M, Buda, G, Burton, D.R, Rossmann, M.G, Kuhn, R.J. | | 登録日 | 2020-10-07 | | 公開日 | 2020-12-16 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Structural Basis of Zika Virus Specific Neutralization in Subsequent Flavivirus Infections.
Viruses, 12, 2020
|
|
7OTL
 | | Structure of a psychrophilic CCA-adding enzyme crystallized by counter-diffusion | | 分子名称: | CCA-adding enzyme, SULFATE ION | | 著者 | Rollet, K, de Wijn, R, Hennig, O, Betat, H, Moerl, M, Lorber, B, Sauter, C. | | 登録日 | 2021-06-10 | | 公開日 | 2021-11-03 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | CCA-addition in the cold: Structural characterization of the psychrophilic CCA-adding enzyme from the permafrost bacterium Planococcus halocryophilus .
Comput Struct Biotechnol J, 19, 2021
|
|
7LN4
 | | Cryo-EM structure of human p97 in complex with Npl4/Ufd1 and polyubiquitinated Ub-Eos (FOM, Class 3) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Pan, M, Yu, Y, Liu, L, Zhao, M. | | 登録日 | 2021-02-06 | | 公開日 | 2021-09-15 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Mechanistic insight into substrate processing and allosteric inhibition of human p97.
Nat.Struct.Mol.Biol., 28, 2021
|
|
7ORZ
 | | Crystal structure of UDP-N-acetylenolpyruvoylglucosamine reductase (MurB) from Pseudomonas aeruginosa in complex with FAD and a pyrazole derivative (fragment 18) | | 分子名称: | 1-phenyl-5-(trifluoromethyl)pyrazole-4-carboxylic acid, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | | 著者 | Acebron-Garcia de Eulate, M, Blundell, T.L, Kim, S.Y, Mendes, V, Abell, C. | | 登録日 | 2021-06-06 | | 公開日 | 2021-11-03 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Discovery of Novel Inhibitors of Uridine Diphosphate- N -Acetylenolpyruvylglucosamine Reductase (MurB) from Pseudomonas aeruginosa , an Opportunistic Infectious Agent Causing Death in Cystic Fibrosis Patients.
J.Med.Chem., 65, 2022
|
|
3NR8
 | | Crystal structure of human SHIP2 | | 分子名称: | CHLORIDE ION, Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 | | 著者 | Tresaugues, L, Welin, M, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, I, Karlberg, T, Kol, S, Kotenyova, T, Kouznetsova, E, Moche, M, Nyman, T, Persson, C, Schuler, H, Schutz, P, Siponen, M.I, Thorsell, A.G, van der Berg, S, Wahlberg, E, Weigelt, J, Nordlund, P, Structural Genomics Consortium (SGC) | | 登録日 | 2010-06-30 | | 公開日 | 2010-08-25 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structural basis for phosphoinositide substrate recognition, catalysis, and membrane interactions in human inositol polyphosphate 5-phosphatases
Structure, 22, 2014
|
|
7LMZ
 | | Cryo-EM structure of human p97 in complex with Npl4/Ufd1 and Ub6 (Class 1) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Hexa-ubiquitin, ... | | 著者 | Pan, M, Yu, Y, Liu, L, Zhao, M. | | 登録日 | 2021-02-06 | | 公開日 | 2021-09-15 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | | 主引用文献 | Mechanistic insight into substrate processing and allosteric inhibition of human p97.
Nat.Struct.Mol.Biol., 28, 2021
|
|
7OQX
 | | Crystal structure of a psychrophilic CCA-adding enzyme in complex with CMPcPP | | 分子名称: | 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, ACETATE ION, CCA-adding enzyme, ... | | 著者 | Rollet, K, de Wijn, R, Bluhm, A, Hennig, O, Betat, H, Moerl, M, Lorber, B, Sauter, C. | | 登録日 | 2021-06-04 | | 公開日 | 2021-11-03 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | CCA-addition in the cold: Structural characterization of the psychrophilic CCA-adding enzyme from the permafrost bacterium Planococcus halocryophilus .
Comput Struct Biotechnol J, 19, 2021
|
|
7OTR
 | | Crystal structure of a psychrophilic CCA-adding enzyme determined by SAD phasing | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, CCA-adding protein, ... | | 著者 | Rollet, K, de Wijn, R, Rios-Santacruz, R, Hennig, O, Betat, H, Moerl, M, Sauter, C. | | 登録日 | 2021-06-10 | | 公開日 | 2021-11-03 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | CCA-addition in the cold: Structural characterization of the psychrophilic CCA-adding enzyme from the permafrost bacterium Planococcus halocryophilus .
Comput Struct Biotechnol J, 19, 2021
|
|
7LMY
 | | Cryo-EM structure of human p97 in complex with NMS-873 in the presence of ATP, Npl4/Ufd1, and Ub6 | | 分子名称: | 3-[3-cyclopentylsulfanyl-5-[[3-methyl-4-(4-methylsulfonylphenyl)phenoxy]methyl]-1,2,4-triazol-4-yl]pyridine, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Pan, M, Yu, Y, Liu, L, Zhao, M. | | 登録日 | 2021-02-06 | | 公開日 | 2021-09-15 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | | 主引用文献 | Mechanistic insight into substrate processing and allosteric inhibition of human p97.
Nat.Struct.Mol.Biol., 28, 2021
|
|
6T1P
 | | ASR Alternansucrase in complex with isomaltononaose | | 分子名称: | Alternansucrase, CALCIUM ION, alpha-D-glucopyranose-(1-6)-alpha-D-glucopyranose-(1-6)-alpha-D-glucopyranose, ... | | 著者 | Cioci, G, Molina, M, Moulis, C, Remaud-Simeon, M. | | 登録日 | 2019-10-04 | | 公開日 | 2020-06-17 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | A specific oligosaccharide-binding site in the alternansucrase catalytic domain mediates alternan elongation.
J.Biol.Chem., 295, 2020
|
|
7LN2
 | | Cryo-EM structure of human p97 in complex with Npl4/Ufd1 and polyubiquitinated Ub-Eos (FOM, Class 1) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Pan, M, Yu, Y, Liu, L, Zhao, M. | | 登録日 | 2021-02-06 | | 公開日 | 2021-09-15 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.63 Å) | | 主引用文献 | Mechanistic insight into substrate processing and allosteric inhibition of human p97.
Nat.Struct.Mol.Biol., 28, 2021
|
|
7LN0
 | | Cryo-EM structure of human p97 in complex with Npl4/Ufd1 and Ub6 (Class 2) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Hexa-ubiquitin, ... | | 著者 | Pan, M, Yu, Y, Liu, L, Zhao, M. | | 登録日 | 2021-02-06 | | 公開日 | 2021-09-15 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | | 主引用文献 | Mechanistic insight into substrate processing and allosteric inhibition of human p97.
Nat.Struct.Mol.Biol., 28, 2021
|
|
1UG2
 | | Solution Structure of Mouse Hypothetical Gene (2610100B20Rik) Product Homologous to Myb DNA-binding Domain | | 分子名称: | 2610100B20Rik gene product | | 著者 | Zhao, C, Kigawa, T, Tochio, N, Koshiba, S, Inoue, M, Shirouzu, M, Terada, T, Yabuki, T, Aoki, M, Seki, E, Matsuda, T, Tanaka, A, Osanai, T, Arakawa, T, Carninci, P, Kawai, J, Hayashizaki, Y, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2003-06-11 | | 公開日 | 2004-06-22 | | 最終更新日 | 2023-12-27 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution Structure of Mouse Hypothetical Gene (2610100B20Rik) Product Homologous to Myb DNA-binding Domain
To be Published
|
|
5GWS
 | | 4-hydroxyisoleucine dehydrogenase complexed with NADH and succinate | | 分子名称: | 4-hydroxyisolecuine dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SUCCINIC ACID | | 著者 | Shi, X, Miyakawa, T, Nakamura, A, Tanokura, M. | | 登録日 | 2016-09-13 | | 公開日 | 2017-10-25 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Engineering a short-chain dehydrogenase/reductase for the stereoselective production of (2S,3R,4S)-4-hydroxyisoleucine with three asymmetric centers.
Sci Rep, 7, 2017
|
|
7LN6
 | | Cryo-EM structure of human p97 in complex with Npl4/Ufd1 and polyubiquitinated Ub-Eos (CHAPSO, Class 2, Open State) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Pan, M, Yu, Y, Liu, L, Zhao, M. | | 登録日 | 2021-02-06 | | 公開日 | 2021-09-15 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.58 Å) | | 主引用文献 | Mechanistic insight into substrate processing and allosteric inhibition of human p97.
Nat.Struct.Mol.Biol., 28, 2021
|
|
5T68
 | | Crystal structure of Syk catalytic domain in complex with a furo[3,2-d]pyrimidine | | 分子名称: | N~4~-cyclopropyl-N~2~-(3-methyl-1H-indazol-6-yl)furo[3,2-d]pyrimidine-2,4-diamine, Tyrosine-protein kinase SYK | | 著者 | Argiriadi, M.A, Hoemann, M, Wilson, N, Banach, D, Burchat, A, Calderwood, D, Clapham, B, Cox, P, Duignan, D.B, Konopacki, D, Somal, G, Vasudevan, A. | | 登録日 | 2016-09-01 | | 公開日 | 2016-10-26 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.93 Å) | | 主引用文献 | Synthesis and optimization of furano[3,2-d]pyrimidines as selective spleen tyrosine kinase (Syk) inhibitors.
Bioorg. Med. Chem. Lett., 26, 2016
|
|
7LN5
 | | Cryo-EM structure of human p97 in complex with Npl4/Ufd1 and polyubiquitinated Ub-Eos (CHAPSO, Class 1, Close State) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Pan, M, Yu, Y, Liu, L, Zhao, M. | | 登録日 | 2021-02-06 | | 公開日 | 2021-09-15 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | | 主引用文献 | Mechanistic insight into substrate processing and allosteric inhibition of human p97.
Nat.Struct.Mol.Biol., 28, 2021
|
|
7LN1
 | | Cryo-EM structure of human p97 in complex with Npl4/Ufd1 and Ub6 (Class 3) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Hexa-ubiquitin, ... | | 著者 | Pan, M, Yu, Y, Liu, L, Zhao, M. | | 登録日 | 2021-02-06 | | 公開日 | 2021-09-15 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Mechanistic insight into substrate processing and allosteric inhibition of human p97.
Nat.Struct.Mol.Biol., 28, 2021
|
|
6TI7
 | | Mixing Abeta(1-40) and Abeta(1-42) peptides generates unique amyloid fibrils | | 分子名称: | Amyloid-beta precursor protein | | 著者 | Cerofolini, L, Ravera, E, Bologna, S, Wiglenda, T, Boddrich, A, Purfurst, B, Benilova, A, Korsak, M, Gallo, G, Rizzo, D, Gonnelli, L, Fragai, M, De Strooper, B, Wanker, E.E, Luchinat, C. | | 登録日 | 2019-11-21 | | 公開日 | 2020-07-22 | | 最終更新日 | 2024-06-19 | | 実験手法 | SOLID-STATE NMR | | 主引用文献 | Mixing A beta (1-40) and A beta (1-42) peptides generates unique amyloid fibrils.
Chem.Commun.(Camb.), 56, 2020
|
|
7LN3
 | | Cryo-EM structure of human p97 in complex with Npl4/Ufd1 and polyubiquitinated Ub-Eos (FOM, Class 2) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Pan, M, Yu, Y, Liu, L, Zhao, M. | | 登録日 | 2021-02-06 | | 公開日 | 2021-09-15 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.45 Å) | | 主引用文献 | Mechanistic insight into substrate processing and allosteric inhibition of human p97.
Nat.Struct.Mol.Biol., 28, 2021
|
|
18GS
 | | GLUTATHIONE S-TRANSFERASE P1-1 COMPLEXED WITH 1-(S-GLUTATHIONYL)-2,4-DINITROBENZENE | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTATHIONE S-(2,4 DINITROBENZENE), GLUTATHIONE S-TRANSFERASE | | 著者 | Oakley, A.J, Lo Bello, M, Ricci, G, Federici, G, Parker, M.W. | | 登録日 | 1997-12-07 | | 公開日 | 1999-01-13 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The ligandin (non-substrate) binding site of human Pi class glutathione transferase is located in the electrophile binding site (H-site).
J.Mol.Biol., 291, 1999
|
|
