5T68

Crystal structure of Syk catalytic domain in complex with a furo[3,2-d]pyrimidine

Summary for 5T68

• Entry DOI: 10.2210/pdb5t68/pdb
• Descriptor: Tyrosine-protein kinase SYK, N~4~-cyclopropyl-N~2~-(3-methyl-1H-indazol-6-yl)furo[3,2-d]pyrimidine-2,4-diamine (3 entities in total)
• Functional Keywords: spleen tyrosine kinase syk catalytic domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cell membrane : P43405
• Total number of polymer chains: 2
• Total formula weight: 68408.71

Authors

Argiriadi, M.A.,Hoemann, M.,Wilson, N.,Banach, D.,Burchat, A.,Calderwood, D.,Clapham, B.,Cox, P.,Duignan, D.B.,Konopacki, D.,Somal, G.,Vasudevan, A. (deposition date: 2016-09-01, release date: 2016-10-26, Last modification date: 2023-10-04)

• Primary citation: Hoemann, M.,Wilson, N.,Argiriadi, M.,Banach, D.,Burchat, A.,Calderwood, D.,Clapham, B.,Cox, P.,Duignan, D.B.,Konopacki, D.,Somal, G.,Vasudevan, A.; Synthesis and optimization of furano[3,2-d]pyrimidines as selective spleen tyrosine kinase (Syk) inhibitors.; Bioorg. Med. Chem. Lett., 26:5562-5567, 2016; PubMed: 27789138; DOI: 10.1016/j.bmcl.2016.09.077

Experimental method

X-RAY DIFFRACTION (2.93 Å)