5T68

Crystal structure of Syk catalytic domain in complex with a furo[3,2-d]pyrimidine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Tyrosine-protein kinase SYK	polymer	291	33884.0	2	UniProt (P43405) Pfam (PF07714) In PDB	Homo sapiens (Human)	Spleen tyrosine kinase,p72-Syk
2	A, B	N~4~-cyclopropyl-N~2~-(3-methyl-1H-indazol-6-yl)furo[3,2-d]pyrimidine-2,4-diamine	non-polymer		320.3	2	Chemie (77V)
3		water	water		18.0	23	Chemie (HOH)

Sequence modifications

A, B: 356 - 635 (UniProt: P43405)

PDB	External Database	Details
Met 353	-	initiating methionine
Ala 354	-	expression tag
Leu 355	-	expression tag
Glu 636	-	expression tag
Gly 637	-	expression tag
His 638	-	expression tag
His 639	-	expression tag
His 640	-	expression tag
His 641	-	expression tag
His 642	-	expression tag
His 643	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	67768.0
Non-Polymers*	Number of molecules	2
	Total formula weight	640.7
All*	Total formula weight	68408.7

*Water molecules are not included.