6S4B
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![BU of 6s4b by Molmil](/molmil-images/mine/6s4b) | Crystal Structure of BRD4(1) bound to inhibitor BUX1 (8) | 分子名称: | (R,R)-2,3-BUTANEDIOL, Bromodomain-containing protein 4, CALCIUM ION, ... | 著者 | Huegle, M. | 登録日 | 2019-06-27 | 公開日 | 2020-12-09 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | 4-Acyl Pyrroles as Dual BET-BRD7/9 Bromodomain Inhibitors Address BETi Insensitive Human Cancer Cell Lines. J.Med.Chem., 63, 2020
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6ZTK
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![BU of 6ztk by Molmil](/molmil-images/mine/6ztk) | Crystal structure of Mialostatin, a gut cystatin from the hard tick Ixodes ricinus | 分子名称: | FRAGMENT OF TRITON X-100, Mialostatin, SULFATE ION | 著者 | Busa, M, Rezacova, P, Mares, M. | 登録日 | 2020-07-20 | 公開日 | 2021-06-02 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Mialostatin, a Novel Midgut Cystatin from Ixodes ricinus Ticks: Crystal Structure and Regulation of Host Blood Digestion. Int J Mol Sci, 22, 2021
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6AZC
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![BU of 6azc by Molmil](/molmil-images/mine/6azc) | |
7NDF
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6S6K
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![BU of 6s6k by Molmil](/molmil-images/mine/6s6k) | Crystal Structure of BRD4(1) bound to inhibitor BUX2 (9) | 分子名称: | (R,R)-2,3-BUTANEDIOL, Bromodomain-containing protein 4, ~{N}-[5-(azepan-1-ylsulfonyl)-2-methoxy-phenyl]-3-methyl-4-oxidanylidene-5,6,7,8-tetrahydro-2~{H}-cyclohepta[c]pyrrole-1-carboxamide | 著者 | Huegle, M. | 登録日 | 2019-07-03 | 公開日 | 2020-12-09 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | 4-Acyl Pyrroles as Dual BET-BRD7/9 Bromodomain Inhibitors Address BETi Insensitive Human Cancer Cell Lines. J.Med.Chem., 63, 2020
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5JXC
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![BU of 5jxc by Molmil](/molmil-images/mine/5jxc) | SynGAP Coiled-coil trimer | 分子名称: | Ras/Rap GTPase-activating protein SynGAP | 著者 | Shang, Y, Zhang, M. | 登録日 | 2016-05-13 | 公開日 | 2016-09-28 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Phase Transition in Postsynaptic Densities Underlies Formation of Synaptic Complexes and Synaptic Plasticity. Cell, 166, 2016
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5C6N
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![BU of 5c6n by Molmil](/molmil-images/mine/5c6n) | protein A | 分子名称: | BH2163 protein | 著者 | Lu, M. | 登録日 | 2015-06-23 | 公開日 | 2015-09-23 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural basis for the blockade of MATE multidrug efflux pumps. Nat Commun, 6, 2015
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8IHO
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![BU of 8iho by Molmil](/molmil-images/mine/8iho) | Crystal structures of SARS-CoV-2 papain-like protease in complex with covalent inhibitors | 分子名称: | Papain-like protease nsp3, ZINC ION, covalent inhibitor | 著者 | Wang, Q, Hu, H, Li, M, Xu, Y. | 登録日 | 2023-02-23 | 公開日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Structure-Based Design of Potent Peptidomimetic Inhibitors Covalently Targeting SARS-CoV-2 Papain-like Protease. Int J Mol Sci, 24, 2023
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7ABT
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6S3Z
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![BU of 6s3z by Molmil](/molmil-images/mine/6s3z) | Structure Of D80A-Fructofuranosidase From Xanthophyllomyces Dendrorhous Complexed With Fructose And hydroquinone | 分子名称: | 1,2-ETHANEDIOL, 1,4-benzoquinone, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Ramirez-Escudero, M, Sanz-Aparicio, J. | 登録日 | 2019-06-26 | 公開日 | 2020-04-29 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Deciphering the molecular specificity of phenolic compounds as inhibitors or glycosyl acceptors of beta-fructofuranosidase from Xanthophyllomyces dendrorhous. Sci Rep, 9, 2019
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8FT6
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![BU of 8ft6 by Molmil](/molmil-images/mine/8ft6) | The von Willebrand factor A domain of human capillary morphogenesis gene II, flexibly fused to the 1TEL crystallization chaperone, Ala-Ala linker variant, SUMO tag-free preparation. | 分子名称: | CITRIC ACID, IODIDE ION, SULFATE ION, ... | 著者 | Gajjar, P.L, Litchfield, C.M, Callahan, M, Redd, N, Doukov, T, Moody, J.D. | 登録日 | 2023-01-11 | 公開日 | 2023-03-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | 主引用文献 | Increasing the bulk of the 1TEL-target linker and retaining the 10×His tag in a 1TEL-CMG2-vWa construct improves crystal order and diffraction limits. Acta Crystallogr D Struct Biol, 79, 2023
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6S2G
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![BU of 6s2g by Molmil](/molmil-images/mine/6s2g) | Structure Of D80A-Fructofuranosidase From Xanthophyllomyces Dendrorhous Complexed With Fructose And Epigallocatechin Gallate (Egcg) | 分子名称: | (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Ramirez-Escudero, M, Sanz-Aparicio, J. | 登録日 | 2019-06-20 | 公開日 | 2020-04-29 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Deciphering the molecular specificity of phenolic compounds as inhibitors or glycosyl acceptors of beta-fructofuranosidase from Xanthophyllomyces dendrorhous. Sci Rep, 9, 2019
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5C9Y
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7Q21
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![BU of 7q21 by Molmil](/molmil-images/mine/7q21) | III2-IV2 respiratory supercomplex from Corynebacterium glutamicum | 分子名称: | (1R)-2-(dodecanoyloxy)-1-[(phosphonooxy)methyl]ethyl tetradecanoate, (2R)-2-(hexadecanoyloxy)-3-{[(S)-hydroxy{[(1R,2R,3R,4R,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9S)-9-methyloctadecanoate, (2S)-1-(hexadecanoyloxy)propan-2-yl (10S)-10-methyloctadecanoate, ... | 著者 | Kovalova, T, Moe, A, Krol, S, Yanofsky, D.J, Bott, M, Sjostrand, D, Rubinstein, J.L, Hogbom, M, Brzezinski, P. | 登録日 | 2021-10-22 | 公開日 | 2022-02-02 | 最終更新日 | 2022-03-16 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | The respiratory supercomplex from C. glutamicum. Structure, 30, 2022
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1HZU
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![BU of 1hzu by Molmil](/molmil-images/mine/1hzu) | DOMAIN SWING UPON HIS TO ALA MUTATION IN NITRITE REDUCTASE OF PSEUDOMONAS AERUGINOSA | 分子名称: | HEME C, HEME D, NITRITE REDUCTASE | 著者 | Brown, K, Cutruzzola, F, Brunori, M, Tegoni, M, Cambillau, C. | 登録日 | 2001-01-26 | 公開日 | 2001-09-26 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Domain swing upon His to Ala mutation in nitrite reductase of Pseudomonas aeruginosa. J.Mol.Biol., 312, 2001
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8I3E
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5C6P
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![BU of 5c6p by Molmil](/molmil-images/mine/5c6p) | protein C | 分子名称: | (2S)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile, protein C, protein D | 著者 | Lu, M. | 登録日 | 2015-06-23 | 公開日 | 2015-09-23 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural basis for the blockade of MATE multidrug efflux pumps. Nat Commun, 6, 2015
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5MAE
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![BU of 5mae by Molmil](/molmil-images/mine/5mae) | CATHEPSIN L IN COMPLEX WITH (2S,4R)-4-(2-Chloro-4-methoxy-benzenesulfonyl)-1-[3-(5-chloro-pyridin-2-yl)-azetidine-3-carbonyl]-pyrrolidine-2-car boxylic acid (1-cyano-cyclopropyl)-amide | 分子名称: | 1,2-ETHANEDIOL, Cathepsin L1, [4-[cyclopentyl(pyrazin-2-ylmethyl)amino]-6-morpholin-4-yl-1,3,5-triazin-2-yl]methylideneazanide | 著者 | Kuglstatter, A, Stihle, M, Benz, J. | 登録日 | 2016-11-03 | 公開日 | 2017-01-11 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1 Å) | 主引用文献 | Inhibition of the Cysteine Protease Human Cathepsin L by Triazine Nitriles: AmideHeteroarene pi-Stacking Interactions and Chalcogen Bonding in the S3 Pocket. ChemMedChem, 12, 2017
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8I3Y
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![BU of 8i3y by Molmil](/molmil-images/mine/8i3y) | Crystal structure of ASCT from Trypanosoma brucei in complex with Succinyl-CoA. | 分子名称: | CALCIUM ION, SUCCINIC ACID, SUCCINYL-COENZYME A, ... | 著者 | Mochizuki, K, Inaoka, D.K, Fukuda, K, Kurasawa, H, Iyoda, K, Nakai, U, Harada, S, Balogun, E.O, Mazet, M, Millerioux, Y, Bringaud, F, Boshart, M, Hirayama, K, Kita, K, Shiba, T. | 登録日 | 2023-01-18 | 公開日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structure of ASCT from Trypanosoma brucei in complex with Succinyl-CoA. To Be Published
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6BB1
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![BU of 6bb1 by Molmil](/molmil-images/mine/6bb1) | Lactate Dehydrogenase in complex with inhibitor (R)-5-((2-chlorophenyl)thio)-6'-(4-fluorophenoxy)-4-hydroxy-2-(thiophen-3-yl)-2,3-dihydro-[2,2'-bipyridin]-6(1H)-one | 分子名称: | (2R)-5-[(2-chlorophenyl)sulfanyl]-6'-(4-fluorophenoxy)-4-hydroxy-2-(thiophen-3-yl)-2,3-dihydro[2,2'-bipyridin]-6(1H)-one, L-lactate dehydrogenase A chain, LACTIC ACID, ... | 著者 | Ultsch, M, Eigenbrot, C. | 登録日 | 2017-10-16 | 公開日 | 2018-10-24 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure-guided optimization and in vivo activities of hydroxylactone and hydroxylactam Inhibitors of Human Lactate Dehydrogenase To Be Published
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8I74
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5BXO
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![BU of 5bxo by Molmil](/molmil-images/mine/5bxo) | Human Tankyrase-2 in Complex with Macrocyclised Extended Peptide cp4n2m3 | 分子名称: | 4,4'-propane-1,3-diylbis(1-methyl-1H-1,2,3-triazole), DIMETHYL SULFOXIDE, SULFATE ION, ... | 著者 | Xu, W, Fischer, G, Hyvonen, M, Itzhaki, L. | 登録日 | 2015-06-09 | 公開日 | 2016-06-29 | 最終更新日 | 2023-03-29 | 実験手法 | X-RAY DIFFRACTION (1.334 Å) | 主引用文献 | Macrocyclized Extended Peptides: Inhibiting the Substrate-Recognition Domain of Tankyrase. J.Am.Chem.Soc., 139, 2017
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8I75
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6RPV
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![BU of 6rpv by Molmil](/molmil-images/mine/6rpv) | Extremely stable monomeric variant of human cystatin C with single amino acid substitution | 分子名称: | Cystatin-C | 著者 | Zhukov, I, Rodziewicz-Motowidlo, S, Maszota-Zieleniak, M, Jurczak, P, Kozak, M. | 登録日 | 2019-05-14 | 公開日 | 2019-07-31 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR, SOLUTION SCATTERING | 主引用文献 | NMR and crystallographic structural studies of the extremely stable monomeric variant of human cystatin C with single amino acid substitution. Febs J., 287, 2020
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8I76
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