5BXO
Human Tankyrase-2 in Complex with Macrocyclised Extended Peptide cp4n2m3
Summary for 5BXO
Entry DOI | 10.2210/pdb5bxo/pdb |
Descriptor | Tankyrase-2, SULFATE ION, DIMETHYL SULFOXIDE, ... (6 entities in total) |
Functional Keywords | stapled peptide, protein-protein interaction, ankyrin-repeat domain, tankyrase, transferase |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm: Q9H2K2 Q9H2K2 |
Total number of polymer chains | 4 |
Total formula weight | 38352.89 |
Authors | Xu, W.,Fischer, G.,Hyvonen, M.,Itzhaki, L. (deposition date: 2015-06-09, release date: 2016-06-29, Last modification date: 2023-03-29) |
Primary citation | Xu, W.,Lau, Y.H.,Fischer, G.,Tan, Y.S.,Chattopadhyay, A.,de la Roche, M.,Hyvonen, M.,Verma, C.,Spring, D.R.,Itzhaki, L.S. Macrocyclized Extended Peptides: Inhibiting the Substrate-Recognition Domain of Tankyrase. J.Am.Chem.Soc., 139:2245-2256, 2017 Cited by PubMed: 28084734DOI: 10.1021/jacs.6b10234 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.334 Å) |
Structure validation
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