5BXO

Human Tankyrase-2 in Complex with Macrocyclised Extended Peptide cp4n2m3

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Tankyrase-2	polymer	164	17736.0	2	UniProt (Q9H2K2) Pfam (PF12796) In PDB	Homo sapiens (Human)	TANK2,ADP-ribosyltransferase diphtheria toxin-like 6,ARTD6,Poly [ADP-ribose] polymerase 5B,TNKS-2,TRF1-interacting ankyrin-related ADP-ribose polymerase 2,Tankyrase II,Tankyrase-like protein,Tankyrase-related protein
2	C, D	Tankyrase-2	polymer	10	828.8	2	UniProt (Q9H2K2) In PDB	Homo sapiens	TANK2,ADP-ribosyltransferase diphtheria toxin-like 6,ARTD6,Poly [ADP-ribose] polymerase 5B,TNKS-2,TRF1-interacting ankyrin-related ADP-ribose polymerase 2,Tankyrase II,Tankyrase-like protein,Tankyrase-related protein
3	A, B	SULFATE ION	non-polymer		96.1	6	Chemie (SO4)
4	A, B	DIMETHYL SULFOXIDE	non-polymer		78.1	3	Chemie (DMS)
5	C, D	4,4'-propane-1,3-diylbis(1-methyl-1H-1,2,3-triazole)	non-polymer		206.2	2	Chemie (4XP)	Homo sapiens
6		water	water		18.0	277	Chemie (HOH)

Sequence modifications

A, B: 488 - 649 (UniProt: Q9H2K2)

PDB	External Database	Details
Gly 486	-	expression tag
Ser 487	-	expression tag

C, D: 1 - 8 (UniProt: Q9H2K2)

PDB	External Database	Details
Ace 0	-	expression tag
Glu 2	Cys 6	conflict
Asp 5	Gly 9	conflict
Glu 8	Ala 12	conflict
Nh2 9	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	37129.6
Non-Polymers*	Number of molecules	11
	Total formula weight	1223.3
All*	Total formula weight	38352.9

*Water molecules are not included.