5BXO
Human Tankyrase-2 in Complex with Macrocyclised Extended Peptide cp4n2m3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tankyrase-2 | polymer | 164 | 17736.0 | 2 | UniProt (Q9H2K2) Pfam (PF12796) | Homo sapiens (Human) | TANK2,ADP-ribosyltransferase diphtheria toxin-like 6,ARTD6,Poly [ADP-ribose] polymerase 5B,TNKS-2,TRF1-interacting ankyrin-related ADP-ribose polymerase 2,Tankyrase II,Tankyrase-like protein,Tankyrase-related protein |
| 2 | C, D (C, D) | Tankyrase-2 | polymer | 10 | 828.8 | 2 | UniProt (Q9H2K2) | Homo sapiens | TANK2,ADP-ribosyltransferase diphtheria toxin-like 6,ARTD6,Poly [ADP-ribose] polymerase 5B,TNKS-2,TRF1-interacting ankyrin-related ADP-ribose polymerase 2,Tankyrase II,Tankyrase-like protein,Tankyrase-related protein |
| 3 | E, F, G, I, J... (A, B) | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 4 | H, L, M (A, B) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 3 | Chemie (DMS) | |||
| 5 | N, O (C, D) | 4,4'-propane-1,3-diylbis(1-methyl-1H-1,2,3-triazole) | non-polymer | 206.2 | 2 | Chemie (4XP) | Homo sapiens | ||
| 6 | P, Q, R, S (A, B, C, D) | water | water | 18.0 | 277 | Chemie (HOH) |
Sequence modifications
A, B: 488 - 649 (UniProt: Q9H2K2)
C, D: 1 - 8 (UniProt: Q9H2K2)
| PDB | External Database | Details |
|---|---|---|
| Gly 486 | - | expression tag |
| Ser 487 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ace 0 | - | expression tag |
| Glu 2 | Cys 6 | conflict |
| Asp 5 | Gly 9 | conflict |
| Glu 8 | Ala 12 | conflict |
| Nh2 9 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 37129.6 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1223.3 | |
| All* | Total formula weight | 38352.9 |
