5BXO

Human Tankyrase-2 in Complex with Macrocyclised Extended Peptide cp4n2m3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003950	molecular_function	NAD+ ADP-ribosyltransferase activity
A	0016055	biological_process	Wnt signaling pathway
A	0032212	biological_process	positive regulation of telomere maintenance via telomerase
A	0051225	biological_process	spindle assembly
B	0003950	molecular_function	NAD+ ADP-ribosyltransferase activity
B	0016055	biological_process	Wnt signaling pathway
B	0032212	biological_process	positive regulation of telomere maintenance via telomerase
B	0051225	biological_process	spindle assembly

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue SO4 A 701

Chain	Residue
A	ALA601
A	LYS602
A	LYS633
A	HOH809
B	ASN626
B	HOH878

---

site_id	AC2
Number of Residues	7
Details	binding site for residue SO4 A 702

Chain	Residue
A	HIS614
A	ARG623
A	HOH869
B	GLN613
A	GLU576
A	LYS580
A	LYS592

---

site_id	AC3
Number of Residues	8
Details	binding site for residue SO4 A 703

Chain	Residue
A	ARG538
A	VAL539
A	SER540
A	LYS557
A	HOH805
A	HOH825
A	HOH856
A	HOH868

---

site_id	AC4
Number of Residues	3
Details	binding site for residue DMS A 704

Chain	Residue
A	CYS512
A	HIS548
B	HIS548

---

site_id	AC5
Number of Residues	10
Details	binding site for residue SO4 B 701

Chain	Residue
A	LYS633
A	ASP634
A	HOH848
B	GLY603
B	LYS604
B	TYR605
B	GLU606
B	HOH811
B	HOH815
B	HOH861

---

site_id	AC6
Number of Residues	5
Details	binding site for residue SO4 B 702

Chain	Residue
B	LYS592
B	GLN613
B	HIS614
B	ARG623
B	HOH806

---

site_id	AC7
Number of Residues	7
Details	binding site for residue SO4 B 703

Chain	Residue
B	ASN537
B	ARG538
B	VAL539
B	SER540
B	LYS557
B	HOH802
B	HOH825

---

site_id	AC8
Number of Residues	5
Details	binding site for residue DMS B 704

Chain	Residue
B	TYR605
B	LYS609
B	ASP624
B	GLY625
B	HOH827

---

site_id	AC9
Number of Residues	3
Details	binding site for residue DMS B 705

Chain	Residue
B	LYS555
B	ASP556
B	GLY559

---

site_id	AD1
Number of Residues	9
Details	binding site for Di-peptide ACE C 0 and ARG C 1

Chain	Residue
A	ASP589
A	TRP591
A	PHE593
A	GLU598
A	HOH879
B	ASP634
B	THR637
C	GLU2
C	HOH207

---

site_id	AD2
Number of Residues	10
Details	binding site for Di-peptide GLU C 8 and NH2 C 9

Chain	Residue
A	TYR569
A	HIS571
A	LYS602
A	HOH837
B	GLU491
B	ARG494
C	ALA7
C	4XP100
C	HOH204
C	HOH206

---

site_id	AD3
Number of Residues	10
Details	binding site for Di-peptide GLU C 8 and NH2 C 9

Chain	Residue
A	TYR569
A	HIS571
A	LYS602
A	HOH837
B	GLU491
B	ARG494
C	ALA7
C	4XP100
C	HOH204
C	HOH206

---

site_id	AD4
Number of Residues	13
Details	binding site for Di-peptide 4XP C 100 and ALA C 3

Chain	Residue
A	ARG525
A	TYR569
B	GLU506
B	THR507
B	GLU523
C	GLU2
C	GLY4
C	GLY6
C	ALA7
C	GLU8
C	NH29
C	HOH202
C	HOH203

---

site_id	AD5
Number of Residues	12
Details	binding site for Di-peptide 4XP C 100 and ALA C 7

Chain	Residue
B	GLU506
B	THR507
B	GLU523
C	ALA3
C	GLY6
C	GLU8
C	NH29
C	HOH203
C	HOH209
A	GLY535
A	TYR569
A	HIS571

---

site_id	AD6
Number of Residues	9
Details	binding site for Di-peptide ACE D 0 and ARG D 1

Chain	Residue
A	ASP634
A	GLY635
A	THR637
B	ASP589
B	TRP591
B	PHE593
B	GLU598
D	GLU2
D	HOH208

---

site_id	AD7
Number of Residues	10
Details	binding site for Di-peptide GLU D 8 and NH2 D 9

Chain	Residue
A	ARG494
B	TYR569
B	HIS571
B	LYS602
B	HOH829
D	ALA7
D	4XP100
D	HOH201
D	HOH210
D	HOH212

---

site_id	AD8
Number of Residues	10
Details	binding site for Di-peptide GLU D 8 and NH2 D 9

Chain	Residue
A	ARG494
B	TYR569
B	HIS571
B	LYS602
B	HOH829
D	ALA7
D	4XP100
D	HOH201
D	HOH210
D	HOH212

---

site_id	AD9
Number of Residues	12
Details	binding site for Di-peptide 4XP D 100 and ALA D 7

Chain	Residue
A	ARG494
A	GLU506
A	GLU523
B	GLY535
B	TYR569
B	HIS571
D	ALA3
D	GLY6
D	GLU8
D	NH29
D	HOH205
D	HOH209

---

site_id	AE1
Number of Residues	13
Details	binding site for Di-peptide 4XP D 100 and ALA D 3

Chain	Residue
A	ARG494
A	GLU506
A	GLU523
B	ARG525
B	TYR569
D	GLU2
D	GLY4
D	GLY6
D	ALA7
D	GLU8
D	HOH203
D	HOH205
D	HOH215

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	64
Details	Repeat: {"description":"ANK 10"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	64
Details	Repeat: {"description":"ANK 11"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	64
Details	Repeat: {"description":"ANK 12"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	16
Details	Region: {"description":"HIF1AN-binding","evidences":[{"source":"PubMed","id":"21251231","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"(3S)-3-hydroxyasparagine; by HIF1AN; partial","evidences":[{"source":"PubMed","id":"18936059","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"(3S)-3-hydroxyhistidine; by HIF1AN; partial","evidences":[{"source":"PubMed","id":"21251231","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---