5MAE

CATHEPSIN L IN COMPLEX WITH (2S,4R)-4-(2-Chloro-4-methoxy-benzenesulfonyl)-1-[3-(5-chloro-pyridin-2-yl)-azetidine-3-carbonyl]-pyrrolidine-2-car boxylic acid (1-cyano-cyclopropyl)-amide

Summary for 5MAE

Entry DOI	10.2210/pdb5mae/pdb
Descriptor	Cathepsin L1, [4-[cyclopentyl(pyrazin-2-ylmethyl)amino]-6-morpholin-4-yl-1,3,5-triazin-2-yl]methylideneazanide, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	protease inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase
Biological source	Homo sapiens (Human)
Cellular location	Lysosome: P07711
Total number of polymer chains	1
Total formula weight	24807.40
Authors	Kuglstatter, A.,Stihle, M.,Benz, J. (deposition date: 2016-11-03, release date: 2017-01-11, Last modification date: 2017-02-22)
Primary citation	Giroud, M.,Ivkovic, J.,Martignoni, M.,Fleuti, M.,Trapp, N.,Haap, W.,Kuglstatter, A.,Benz, J.,Kuhn, B.,Schirmeister, T.,Diederich, F. Inhibition of the Cysteine Protease Human Cathepsin L by Triazine Nitriles: AmideHeteroarene pi-Stacking Interactions and Chalcogen Bonding in the S3 Pocket. ChemMedChem, 12:257-270, 2017 Cited by PubMed: 27992115 DOI: 10.1002/cmdc.201600563 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1 Å)

Structure validation