7ABT

Structure of PPIA in complex with PR dipeptide repeat

Summary for 7ABT

• Entry DOI: 10.2210/pdb7abt/pdb
• Descriptor: Peptidyl-prolyl cis-trans isomerase A, PRO-ARG-PRO-ARG-PRO-ARG-PRO-ARG (3 entities in total)
• Functional Keywords: cyclophilin a, peptidylprolyl isomerase a, pro arg dipeptide repeat, isomerase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 18811.44

Authors

Babu, M.,Zweckstetter, M.,Becker, S. (deposition date: 2020-09-08, release date: 2021-06-23, Last modification date: 2024-01-31)

• Primary citation: Babu, M.,Favretto, F.,de Opakua, A.I.,Rankovic, M.,Becker, S.,Zweckstetter, M.; Proline/arginine dipeptide repeat polymers derail protein folding in amyotrophic lateral sclerosis.; Nat Commun, 12:3396-3396, 2021; PubMed: 34099711; DOI: 10.1038/s41467-021-23691-y

Experimental method

X-RAY DIFFRACTION (1.31 Å)