3GA4
 
 | | Crystal structure of Ost6L (photoreduced form) | | 分子名称: | 1,2-ETHANEDIOL, Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit OST6, TETRAETHYLENE GLYCOL | | 著者 | Stirnimann, C.U, Grimshaw, J.P.A, Schulz, B.L, Brozzo, M.S, Fritsch, F, Glockshuber, R, Capitani, G, Gruetter, M.G, Aebi, M. | | 登録日 | 2009-02-16 | | 公開日 | 2009-06-16 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Oxidoreductase activity of oligosaccharyltransferase subunits Ost3p and Ost6p defines site-specific glycosylation efficiency.
Proc.Natl.Acad.Sci.USA, 106, 2009
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2VK8
 | | Crystal structure of the Saccharomyces cerevisiae pyruvate decarboxylase variant E477Q in complex with its substrate | | 分子名称: | (2S)-2-HYDROXYPROPANOIC ACID, MAGNESIUM ION, PYRUVATE DECARBOXYLASE ISOZYME 1, ... | | 著者 | Kutter, S, Weik, M, Weiss, M.S, Konig, S. | | 登録日 | 2007-12-17 | | 公開日 | 2009-01-27 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | | 主引用文献 | Covalently Bound Substrate at the Regulatory Site of Yeast Pyruvate Decarboxylases Triggers Allosteric Enzyme Activation.
J.Biol.Chem., 284, 2009
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3G9B
 | | Crystal structure of reduced Ost6L | | 分子名称: | Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit OST6 | | 著者 | Stirnimann, C.U, Grimshaw, J.P.A, Schulz, B.L, Brozzo, M.S, Fritsch, F, Glockshuber, R, Capitani, G, Gruetter, M.G, Aebi, M. | | 登録日 | 2009-02-13 | | 公開日 | 2009-06-16 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | Oxidoreductase activity of oligosaccharyltransferase subunits Ost3p and Ost6p defines site-specific glycosylation efficiency.
Proc.Natl.Acad.Sci.USA, 106, 2009
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7COZ
 | | Crystal Structure of double mutant Y115E Y117E human Secretory Glutaminyl Cyclase in complex with LSB-41 | | 分子名称: | 1,2-ETHANEDIOL, 1-[3-(2-methyl-4-thiophen-2-yl-1,3-thiazol-5-yl)propanoyl]piperidine-4-carboxamide, Glutaminyl-peptide cyclotransferase, ... | | 著者 | Dileep, K.V, Ihara, K, Sakai, N, Shirozu, M, Zhang, K.Y.J. | | 登録日 | 2020-08-05 | | 公開日 | 2021-01-13 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Piperidine-4-carboxamide as a new scaffold for designing secretory glutaminyl cyclase inhibitors.
Int.J.Biol.Macromol., 170, 2020
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5H24
 | | EED in complex with PRC2 allosteric inhibitor compound 8 | | 分子名称: | 5-(furan-2-ylmethylamino)-[1,2,4]triazolo[4,3-a]pyridine-6-carbonitrile, Histone-lysine N-methyltransferase EZH2, Polycomb protein EED | | 著者 | Zhao, K, Zhao, M, Luo, X, Zhang, H. | | 登録日 | 2016-10-14 | | 公開日 | 2017-01-25 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy
J. Med. Chem., 60, 2017
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4YJR
 | | SYK kinase domain in complex with inhibitor GTC000225 | | 分子名称: | 3-(1H-indazol-4-yl{2-[(1-methyl-1H-indazol-5-yl)amino]pyrimidin-4-yl}amino)propan-1-ol, Tyrosine-protein kinase SYK | | 著者 | Somers, D.O, Neu, M, Stuckey, J. | | 登録日 | 2015-03-03 | | 公開日 | 2015-09-30 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.32 Å) | | 主引用文献 | Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor.
Bioorg. Med. Chem. Lett., 21, 2011
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4YJQ
 | | SYK kinase domain in complex with inhibitor GTC000224 | | 分子名称: | 3-[1H-indazol-4-yl(2-{[3-(4-methyl-1,3-oxazol-5-yl)phenyl]amino}pyrimidin-4-yl)amino]propan-1-ol, Tyrosine-protein kinase SYK | | 著者 | Somers, D.O, Neu, M, Stuckey, J. | | 登録日 | 2015-03-03 | | 公開日 | 2015-09-30 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.34 Å) | | 主引用文献 | Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor.
Bioorg. Med. Chem. Lett., 21, 2011
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4FLA
 | | Crystal structure of human RPRD1B, carboxy-terminal domain | | 分子名称: | Regulation of nuclear pre-mRNA domain-containing protein 1B, UNKNOWN ATOM OR ION | | 著者 | Ni, Z, Xu, C, Tempel, W, El Bakkouri, M, Loppnau, P, Guo, X, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Greenblatt, J.F, Structural Genomics Consortium (SGC) | | 登録日 | 2012-06-14 | | 公開日 | 2012-08-22 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation.
Nat.Struct.Mol.Biol., 21, 2014
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6KG2
 | | Human MTHFD2 in complex with Compound 18 | | 分子名称: | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial, N-[2-chloranyl-4-[[7-methyl-8-(4-methylpiperazin-1-yl)-5-oxidanylidene-2,4-dihydro-1H-chromeno[3,4-c]pyridin-3-yl]carbonyl]phenyl]methanesulfonamide, ... | | 著者 | Suzuki, M, Matsui, Y, Ota, M, Kawai, J. | | 登録日 | 2019-07-10 | | 公開日 | 2019-11-13 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Discovery of a Potent, Selective, and Orally Available MTHFD2 Inhibitor (DS18561882) with in Vivo Antitumor Activity.
J.Med.Chem., 62, 2019
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5GWR
 | | 4-hydroxyisoleucine dehydrogenase complexed with NADH | | 分子名称: | 1,2-ETHANEDIOL, 4-hydroxyisolecuine dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | 著者 | Shi, X, Miyakawa, T, Nakamura, A, Tanokura, M. | | 登録日 | 2016-09-13 | | 公開日 | 2017-10-25 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Engineering a short-chain dehydrogenase/reductase for the stereoselective production of (2S,3R,4S)-4-hydroxyisoleucine with three asymmetric centers
Sci Rep, 7, 2017
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4UTP
 | | Crystal structure of pneumococcal surface antigen PsaA in the Cd- bound, closed state | | 分子名称: | CADMIUM ION, MANGANESE ABC TRANSPORTER SUBSTRATE-BINDING LIPOPROTEIN | | 著者 | Luo, Z, Counago, R.M, Maher, M, Kobe, B. | | 登録日 | 2014-07-22 | | 公開日 | 2014-08-13 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae.
Nat Commun, 6, 2015
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8K5Q
 | | Crystal structure of YajQ STM0435 with c-di-GMP | | 分子名称: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), YajQ | | 著者 | Dai, Y, Zhang, M, Wang, W, Li, B. | | 登録日 | 2023-07-23 | | 公開日 | 2024-04-17 | | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | | 主引用文献 | A c-di-GMP binding effector STM0435 modulates flagellar motility and pathogenicity in Salmonella
Virulence, 15, 2024
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4YC4
 | | Crystal structure of phosphatidyl inositol 4-kinase II alpha in complex with nucleotide analog | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Phosphatidylinositol 4-kinase type 2-alpha,Lysozyme,Phosphatidylinositol 4-kinase type 2-alpha, [(1S,3S,4S)-3-(6-amino-9H-purin-9-yl)bicyclo[2.2.1]hept-1-yl]methanol | | 著者 | Klima, M, Boura, E. | | 登録日 | 2015-02-19 | | 公開日 | 2015-07-15 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | | 主引用文献 | The high-resolution crystal structure of phosphatidylinositol 4-kinase II beta and the crystal structure of phosphatidylinositol 4-kinase II alpha containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor design.
Acta Crystallogr.,Sect.D, 71, 2015
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6K54
 | | Hyperthermophilic GH6 cellobiohydrolase II (HmCel6A) in complex with trisaccharide | | 分子名称: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Baba, S, Takeda, M, Okuma, J, Hirose, Y, Nishimura, A, Takata, M, Oda, K, Shibata, D, Kondo, Y, Kumasaka, T. | | 登録日 | 2019-05-28 | | 公開日 | 2020-06-03 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.905 Å) | | 主引用文献 | Novel hyperthermophilic cellobiohydrolase II isolated from hot spring microbial community
To Be Published
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8K4Z
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7Y7D
 | | Structure of the Bacterial Ribosome with human tRNA Asp(Q34) and mRNA(GAU) | | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | | 著者 | Ishiguro, K, Yokoyama, T, Shirouzu, M, Suzuki, T. | | 登録日 | 2022-06-22 | | 公開日 | 2023-10-25 | | 最終更新日 | 2023-12-27 | | 実験手法 | ELECTRON MICROSCOPY (2.58 Å) | | 主引用文献 | Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth.
Cell, 186, 2023
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7Y7C
 | | Structure of the Bacterial Ribosome with human tRNA Asp(G34) and mRNA(GAU) | | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | | 著者 | Ishiguro, K, Yokoyama, T, Shirouzu, M, Suzuki, T. | | 登録日 | 2022-06-22 | | 公開日 | 2023-10-25 | | 最終更新日 | 2023-12-27 | | 実験手法 | ELECTRON MICROSCOPY (2.51 Å) | | 主引用文献 | Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth.
Cell, 186, 2023
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7Y7F
 | | Structure of the Bacterial Ribosome with human tRNA Asp(ManQ34) and mRNA(GAC) | | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | | 著者 | Ishiguro, K, Yokoyama, T, Shirouzu, M, Suzuki, T. | | 登録日 | 2022-06-22 | | 公開日 | 2023-10-25 | | 最終更新日 | 2023-12-27 | | 実験手法 | ELECTRON MICROSCOPY (2.43 Å) | | 主引用文献 | Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth.
Cell, 186, 2023
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7Y7E
 | | Structure of the Bacterial Ribosome with human tRNA Asp(ManQ34) and mRNA(GAU) | | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | | 著者 | Ishiguro, K, Yokoyama, T, Shirouzu, M, Suzuki, T. | | 登録日 | 2022-06-22 | | 公開日 | 2023-10-25 | | 最終更新日 | 2023-12-27 | | 実験手法 | ELECTRON MICROSCOPY (2.41 Å) | | 主引用文献 | Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth.
Cell, 186, 2023
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8K4I
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7Y7G
 | | Structure of the Bacterial Ribosome with human tRNA Tyr(GalQ34) and mRNA(UAU) | | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | | 著者 | Ishiguro, K, Yokoyama, T, Shirouzu, M, Suzuki, T. | | 登録日 | 2022-06-22 | | 公開日 | 2023-10-25 | | 最終更新日 | 2023-12-27 | | 実験手法 | ELECTRON MICROSCOPY (2.34 Å) | | 主引用文献 | Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth.
Cell, 186, 2023
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6K52
 | | Hyperthermophilic GH6 cellobiohydrolase (HmCel6A) from the microbial flora of a Japanese hot spring | | 分子名称: | ACETATE ION, CALCIUM ION, GH6 cellobiohydrolase, ... | | 著者 | Baba, S, Takeda, M, Okuma, J, Hirose, Y, Nishimura, A, Takata, M, Oda, K, Shibata, D, Kondo, Y, Kumasaka, T. | | 登録日 | 2019-05-28 | | 公開日 | 2020-06-03 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.68000138 Å) | | 主引用文献 | A hyperthermophilic cellobiohydrolase mined from a hot spring metagenomic data
To Be Published
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6D3W
 | | Chromosomal trehalose-6-phosphate phosphatase from P. aeruginosa | | 分子名称: | 1,2-ETHANEDIOL, ACETIC ACID, CALCIUM ION, ... | | 著者 | Hofmann, A, Cross, M, Park, S.-Y. | | 登録日 | 2018-04-17 | | 公開日 | 2018-05-09 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Trehalose 6-phosphate phosphatases of Pseudomonas aeruginosa.
FASEB J., 32, 2018
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7Y7H
 | | Structure of the Bacterial Ribosome with human tRNA Tyr(GalQ34) and mRNA(UAC) | | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | | 著者 | Ishiguro, K, Yokoyama, T, Shirouzu, M, Suzuki, T. | | 登録日 | 2022-06-22 | | 公開日 | 2023-10-25 | | 最終更新日 | 2023-12-27 | | 実験手法 | ELECTRON MICROSCOPY (2.51 Å) | | 主引用文献 | Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth.
Cell, 186, 2023
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7CP0
 | | Crystal Structure of double mutant Y115E Y117E human Secretory Glutaminyl Cyclase | | 分子名称: | 1,2-ETHANEDIOL, Glutaminyl-peptide cyclotransferase, SULFATE ION, ... | | 著者 | Dileep, K.V, Ihara, K, Sakai, N, Shirozu, M, Zhang, K.Y.J. | | 登録日 | 2020-08-05 | | 公開日 | 2021-01-13 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Piperidine-4-carboxamide as a new scaffold for designing secretory glutaminyl cyclase inhibitors.
Int.J.Biol.Macromol., 170, 2020
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