7CP0

Crystal Structure of double mutant Y115E Y117E human Secretory Glutaminyl Cyclase

Summary for 7CP0

• Entry DOI: 10.2210/pdb7cp0/pdb
• Descriptor: Glutaminyl-peptide cyclotransferase, ZINC ION, SULFATE ION, ... (5 entities in total)
• Functional Keywords: glutaminyl-peptide cyclotransferase, sqc, alzheimer's disease, pyroglutamate, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 3
• Total formula weight: 113781.21

Authors

Dileep, K.V.,Ihara, K.,Sakai, N.,Shirozu, M.,Zhang, K.Y.J. (deposition date: 2020-08-05, release date: 2021-01-13, Last modification date: 2023-11-29)

• Primary citation: Dileep, K.V.,Sakai, N.,Ihara, K.,Kato-Murayama, M.,Nakata, A.,Ito, A.,Sivaraman, D.M.,Shin, J.W.,Yoshida, M.,Shirouzu, M.,Zhang, K.Y.J.; Piperidine-4-carboxamide as a new scaffold for designing secretory glutaminyl cyclase inhibitors.; Int.J.Biol.Macromol., 170:415-423, 2020; PubMed: 33373636; DOI: 10.1016/j.ijbiomac.2020.12.118

Experimental method

X-RAY DIFFRACTION (1.7 Å)