4YC4

Crystal structure of phosphatidyl inositol 4-kinase II alpha in complex with nucleotide analog

Summary for 4YC4

• Entry DOI: 10.2210/pdb4yc4/pdb
• Related: 4PLA
• Descriptor: Phosphatidylinositol 4-kinase type 2-alpha,Lysozyme,Phosphatidylinositol 4-kinase type 2-alpha, [(1S,3S,4S)-3-(6-amino-9H-purin-9-yl)bicyclo[2.2.1]hept-1-yl]methanol, ADENOSINE-5'-DIPHOSPHATE, ... (4 entities in total)
• Functional Keywords: kinase, complex, inhibitor, transferase
• Biological source: Homo sapiens (Human); More
• Cellular location: Golgi apparatus, trans-Golgi network membrane ; Lipid-anchor : Q9BTU6
• Total number of polymer chains: 1
• Total formula weight: 63927.42

Authors

Klima, M.,Boura, E. (deposition date: 2015-02-19, release date: 2015-07-15, Last modification date: 2017-09-06)

• Primary citation: Klima, M.,Baumlova, A.,Chalupska, D.,Hrebabecky, H.,Dejmek, M.,Nencka, R.,Boura, E.; The high-resolution crystal structure of phosphatidylinositol 4-kinase II beta and the crystal structure of phosphatidylinositol 4-kinase II alpha containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor design.; Acta Crystallogr.,Sect.D, 71:1555-1563, 2015; PubMed: 26143926; DOI: 10.1107/S1399004715009505

Experimental method

X-RAY DIFFRACTION (2.58 Å)